دورية أكاديمية
Chromosomal R-loops: who R they?
| العنوان: | Chromosomal R-loops: who R they? |
|---|---|
| المؤلفون: | Székvölgyi L; MTA-DE Momentum, Genome Architecture and Recombination Research Group, Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, Debrecen, 4032, Hungary. lorantsz@med.unideb.hu. |
| المصدر: | Biologia futura [Biol Futur] 2024 Jun; Vol. 75 (2), pp. 177-182. Date of Electronic Publication: 2024 Mar 08. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101738236 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2676-8607 (Electronic) Linking ISSN: 26768607 NLM ISO Abbreviation: Biol Futur Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Cham, Switzerland] : [Budapest] : Springer International Publishing ; Akadémiai Kiadó Original Publication: [Budapest] : Akadémiai Kiadó, [2019]- |
| مواضيع طبية MeSH: | R-Loop Structures*, Humans ; Genomic Instability/genetics ; Animals |
| مستخلص: | R-loops, composed of DNA-RNA hybrids and displaced single-stranded DNA, are known to pose a severe threat to genome integrity. Therefore, extensive research has focused on identifying regulatory proteins involved in controlling R-loop levels. These proteins play critical roles in preventing R-loop accumulation and associated genome instability. Herein I summarize recent knowledge on R-loop regulators affecting R-loop homeostasis, involving a wide array of R-loop screening methods that have enabled their characterization, from forward genetic and siRNA-based screens to proximity labeling and machine learning. These approaches not only deepen our understanding on R-loop formation processes, but also hold promise to find new targets in R-loop dysregulation associated with human pathologies. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | NKFIH-NNE-130913 National Research, Development and Innovation Office |
| فهرسة مساهمة: | Keywords: R-loop disorder; R-loop regulator; R-loop screen; RNA-DNA hybrid |
| تواريخ الأحداث: | Date Created: 20240308 Date Completed: 20240617 Latest Revision: 20240617 |
| رمز التحديث: | 20240617 |
| DOI: | 10.1007/s42977-024-00213-7 |
| PMID: | 38457033 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. | تدمد: | 2676-8607 |
|---|---|
| DOI: | 10.1007/s42977-024-00213-7 |