دورية أكاديمية
Cefazolin as a predictor of urinary cephalosporin activity in indicated Enterobacterales.
| العنوان: | Cefazolin as a predictor of urinary cephalosporin activity in indicated Enterobacterales. |
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| المؤلفون: | Bryson AL; Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia, USA., Bhalodi A; Scientific and Medical Affairs Consulting, Newton, Pennsylvania, USA., Liesman RM; Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Mathers AJ; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA.; Clinical Microbiology Laboratory, Department of Pathology, University of Virginia Health, Charlottesville, Virginia, USA. |
| المصدر: | Journal of clinical microbiology [J Clin Microbiol] 2024 Apr 10; Vol. 62 (4), pp. e0078821. Date of Electronic Publication: 2024 Mar 08. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7505564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-660X (Electronic) Linking ISSN: 00951137 NLM ISO Abbreviation: J Clin Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology. |
| مواضيع طبية MeSH: | Cefazolin*/pharmacology , Cefazolin*/therapeutic use , Urinary Tract Infections*/drug therapy , Urinary Tract Infections*/microbiology, Humans ; Cephalosporins/pharmacology ; Cephalothin ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests ; Escherichia coli ; Monobactams |
| مستخلص: | Traditionally, cephalothin susceptibility results were used to predict the susceptibility of additional cephalosporins; however, in 2013-2014, the Clinical and Laboratory Standards Institute (CLSI) revisited this practice and determined that cefazolin is a more accurate proxy than cephalothin for uncomplicated urinary tract infections (uUTIs). Therefore, a cefazolin surrogacy breakpoint was established to predict the susceptibility of seven oral cephalosporins for Escherichia coli , Klebsiella pneumoniae , and Proteus mirabilis in the context of uUTIs. Clinical microbiology laboratories face several operational challenges when implementing the cefazolin surrogacy breakpoint, which may lead to confusion for the best path forward. Here, we review the historical context and data behind the surrogacy breakpoints, review PK/PD profiles for oral cephalosporins, discuss challenges in deploying the breakpoint, and highlight the limited clinical outcome data in this space. Competing Interests: The authors declare no conflict of interest. |
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| فهرسة مساهمة: | Keywords: UTI; antimicrobial susceptibility testing; breakpoints; cefazolin; cefazolin surrogate; oral cephalosporins; uncomplicated UTI; urinary tract infection |
| المشرفين على المادة: | IHS69L0Y4T (Cefazolin) 0 (Cephalosporins) R72LW146E6 (Cephalothin) 0 (Anti-Bacterial Agents) 0 (Monobactams) |
| تواريخ الأحداث: | Date Created: 20240308 Date Completed: 20240411 Latest Revision: 20240517 |
| رمز التحديث: | 20240517 |
| مُعرف محوري في PubMed: | PMC11005412 |
| DOI: | 10.1128/jcm.00788-21 |
| PMID: | 38457194 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-660X |
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| DOI: | 10.1128/jcm.00788-21 |