دورية أكاديمية
Association of the polymorphisms rs179008 ( TLR7 ), rs2004640 ( IRF5 ), rs1800795 ( IL-6 ) and rs2280788 ( CCL5 ) with systemic lupus erythematosus in women of Mayan ethnicity from Yucatan.
| العنوان: | Association of the polymorphisms rs179008 ( TLR7 ), rs2004640 ( IRF5 ), rs1800795 ( IL-6 ) and rs2280788 ( CCL5 ) with systemic lupus erythematosus in women of Mayan ethnicity from Yucatan. |
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| المؤلفون: | Nakazawa-Ueji YE; Hematology Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico., Valencia-Pacheco G; Hematology Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico., González-Herrera LJ; Genetic Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico., Chan-Chalé L; Hematology Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico., Velasco-Cárdenas RM; Hematology Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico., Carreño-Gonzalez MJ; Hematology Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico., Pérez-Mendoza G; Hematology Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico., Amaro-Adrián GI; Hematology Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico., Rodríguez-Dzul EA; Hematology Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico., Quintal-Ortiz IG; Hematology Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico., Angulo-Ramírez AV; Rheumatology Department, Agustin O'Horan General Hospital, Yucatan, Mexico., López-Villanueva RF; Rheumatology Department, Regional Hospital General (ISSSTE), Health Service Yucatan, Yucatan, Mexico. |
| المصدر: | Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2024 Mar 08, pp. 1-17. Date of Electronic Publication: 2024 Mar 08. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 100892832 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2335 (Electronic) Linking ISSN: 15257770 NLM ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia : Taylor & Francis Original Publication: Monticello, NY : Marcel Dekker, c2000- |
| مستخلص: | Introduction: IFN-α is the main cytokine in SLE, and single nucleotide polymorphisms (SNP) in different genes could induce it. Aim: To determine the association of rs2004640 ( IRF5 ), rs179008 ( TLR7 ), rs1800795 ( IL-6 ) and rs2280788 ( CCL5 ) with SLE in Mexican women with Mayan ethnicity. Methods: DNA and RNA were isolated from the peripheral blood of 110 patients and 200 healthy control subjects. SNP genotyping and gene expression analysis of IRF5, TLR7, IL-6 and IFN-α were determined by real-time PCR and analyzed with SNP Stat, Stata 10.1 and Graph Pad Prism v5. Results: rs2004640, rs179008, and rs1800795 in both groups were according to Hardy-Weinberg equilibrium. Risk alleles rs179008T and rs2004640T frequencies were higher in controls ( p = 0.015 and p = 0.028, respectively), whereas rs179008A frequency was higher in patients ( p = 0.015). Allelic combination AGT frequency was higher in patients ( p = 0.001). IL-6 rs1800795C > G and CCL5 rs2280788G > C frequencies did not show significant differences ( p > 0.05), being rs2280788G ( CCL5 ) monomorphic in controls. SLE patients showed higher TLR7, IRF5, IL6, and IFN-α mRNA levels. IRF5 expression was higher in SLE patients homozygous for rs2004640T ( IRF5 ). Conclusion: This work showed the contribution of TLR7 and IRF5 in SLE pathogenesis in Mayan females from Yucatan. |
| فهرسة مساهمة: | Keywords: IFN-α; IRF5; Mayan; Systemic lupus erythematosus; TLR7; Yucatecan |
| تواريخ الأحداث: | Date Created: 20240309 Latest Revision: 20240309 |
| رمز التحديث: | 20240309 |
| DOI: | 10.1080/15257770.2024.2325438 |
| PMID: | 38459707 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2335 |
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| DOI: | 10.1080/15257770.2024.2325438 |