دورية أكاديمية
Sex differences in trends and in-hospital outcomes of acute myocardial infarction in patients with familial hypercholesterolemia: insights from a large national database.
| العنوان: | Sex differences in trends and in-hospital outcomes of acute myocardial infarction in patients with familial hypercholesterolemia: insights from a large national database. |
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| المؤلفون: | Rivera FB; Department of Medicine, Lincoln Medical Center, New York, NY, USA., Cha SW; Cebu Institute of Medicine, Cebu City, Philippines., Liston MB; Cebu Institute of Medicine, Cebu City, Philippines., Redula S; Cebu Institute of Medicine, Cebu City, Philippines., Bantayan NRB; University of the Philippines College of Medicine - Philippine General Hospital, Manila, Philippines., Shah N; Division of Cardiology, Duke University Medical Center, Durham, NC, USA., Mamas MA; Keele Cardiovascular Research Group, Center for Prognosis Research, Keele University, Stoke-on-Trent, UK., Volgman AS; Division of Cardiology, Rush University Medical Center, Chicago, IL, USA. |
| المصدر: | Expert review of cardiovascular therapy [Expert Rev Cardiovasc Ther] 2024 Apr-May; Vol. 22 (4-5), pp. 193-200. Date of Electronic Publication: 2024 Mar 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101182328 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8344 (Electronic) Linking ISSN: 14779072 NLM ISO Abbreviation: Expert Rev Cardiovasc Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London, UK : Future Drugs Ltd. |
| مواضيع طبية MeSH: | Hyperlipoproteinemia Type II*/complications , Hyperlipoproteinemia Type II*/epidemiology , Hyperlipoproteinemia Type II*/therapy , Myocardial Infarction*/mortality , Myocardial Infarction*/therapy , Myocardial Infarction*/epidemiology , Hospital Mortality*/trends , Databases, Factual* , Percutaneous Coronary Intervention*/methods , Percutaneous Coronary Intervention*/statistics & numerical data, Humans ; Male ; Female ; Middle Aged ; Aged ; Sex Factors ; United States/epidemiology ; Coronary Artery Bypass ; Adult ; Aged, 80 and over ; Hospitalization/statistics & numerical data |
| مستخلص: | Background: Sex differences in clinical outcomes following acute myocardial infarction (AMI) are well known. However, data on sex differences among patients with familial hypercholesterolemia (FH) are limited. We aimed to explore sex differences in outcomes of AMI among patients with FH from a national administrative dataset. Research Design and Methods: We utilized the National Inpatient Sample to identify admissions with a primary diagnosis of AMI and a secondary diagnosis of FH. Our primary outcome of interest was in-hospital mortality; secondary outcomes were performance of percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), respiratory complications, use of inotropes, use of mechanical circulatory support (MCS), bleeding complications, transfusion and facility discharge. We adjusted for demographics (model A), comorbidities (model B), and intervention (model C). Results: Between October 2016 and December 2020, 5,714,993 admissions with a primary diagnosis of AMI were identified, of which 3,035 (0.05%) had a secondary diagnosis of FH. In-hospital mortality did not differ between men and women (Model C, adjusted OR = 0.85; 95% CI 0.28-2.60, p = 0.773). There was no sex difference in the secondary outcomes. Conclusion: Despite generally being older and having more comorbidities, women with FH fair equally with men with FH in terms of mortality during AMI admission. |
| فهرسة مساهمة: | Keywords: Sex differences; Sex disparities; acute myocardial infarction; cardiovascular outcomes; familial hypercholesterolemia |
| تواريخ الأحداث: | Date Created: 20240309 Date Completed: 20240513 Latest Revision: 20240513 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1080/14779072.2024.2329720 |
| PMID: | 38459907 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-8344 |
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| DOI: | 10.1080/14779072.2024.2329720 |