دورية أكاديمية
Serum and salivary inflammatory biomarkers in juvenile idiopathic arthritis-an explorative cross-sectional study.
| العنوان: | Serum and salivary inflammatory biomarkers in juvenile idiopathic arthritis-an explorative cross-sectional study. |
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| المؤلفون: | Cetrelli L; Center for Oral Health Services and Research (TkMidt), Trondheim, Norway. lence@tkmidt.no.; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. lence@tkmidt.no., Lundestad A; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Children's Clinic, St. Olavs University Hospital, Trondheim, Norway., Gil EG; Knarvik Orthodontics, Alver, Norway., Fischer J; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen (UiB), Bergen, Norway., Halbig J; Public Dental Health Service Competence Centre of Northern Norway (TkNN), Tromsø, Norway.; Department of Clinical Dentistry, The Arctic University of Norway (UiT), Tromsø, Norway., Frid P; Public Dental Health Service Competence Centre of Northern Norway (TkNN), Tromsø, Norway.; Department of Clinical Dentistry, The Arctic University of Norway (UiT), Tromsø, Norway.; Department of Otorhinolaryngology, Division of Oral and Maxillofacial Surgery, University Hospital North Norway, Tromsø, Norway., Angenete O; Department of Radiology and Nuclear Medicine, St. Olav Hospital HF, Trondheim University Hospital, Trondheim, Norway.; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Rosén A; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen (UiB), Bergen, Norway.; Department of Oral and Maxillofacial Surgery, Haukeland University Hospital, Bergen, Norway.; Department of Oral and Maxillofacial Surgery, Eastman Institute, Public Dental Health Service, Stockholm, Sweden., Tylleskär KB; Child and Youth Clinic, Haukeland University Hospital, Bergen, Norway., Luukko K; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen (UiB), Bergen, Norway., Nordal E; Department of Clinical Medicine, The Arctic University of Norway (UiT), Tromsø, Norway.; Department of Pediatrics, University Hospital of Northern Norway, Tromsø, Norway., Åstrøm AN; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen (UiB), Bergen, Norway.; Oral Health Centre of Expertise in Western Norway (TkV), Bergen, Norway., Skeie MS; Center for Oral Health Services and Research (TkMidt), Trondheim, Norway.; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen (UiB), Bergen, Norway., Stunes AK; Center for Oral Health Services and Research (TkMidt), Trondheim, Norway., Bletsa A; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen (UiB), Bergen, Norway.; Oral Health Centre of Expertise in Western Norway (TkV), Bergen, Norway., Sen A; Center for Oral Health Services and Research (TkMidt), Trondheim, Norway.; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Feuerherm AJ; Center for Oral Health Services and Research (TkMidt), Trondheim, Norway., Rygg M; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Children's Clinic, St. Olavs University Hospital, Trondheim, Norway. |
| المصدر: | Pediatric rheumatology online journal [Pediatr Rheumatol Online J] 2024 Mar 09; Vol. 22 (1), pp. 36. Date of Electronic Publication: 2024 Mar 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101248897 Publication Model: Electronic Cited Medium: Internet ISSN: 1546-0096 (Electronic) Linking ISSN: 15460096 NLM ISO Abbreviation: Pediatr Rheumatol Online J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2007- : [London] : BioMed Central Original Publication: [Chicago, Ill. : University of Chicago, 2003]- |
| مواضيع طبية MeSH: | Arthritis, Juvenile*/diagnosis , Arthritis, Juvenile*/drug therapy, Child ; Adolescent ; Female ; Humans ; Male ; Cross-Sectional Studies ; Saliva ; Inflammation ; Biomarkers |
| مستخلص: | Background: Biomarkers may be useful in monitoring disease activity in juvenile idiopathic arthritis (JIA). With new treatment options and treatment goals in JIA, there is an urgent need for more sensitive and responsive biomarkers. Objective: We aimed to investigate the patterns of 92 inflammation-related biomarkers in serum and saliva in a group of Norwegian children and adolescents with JIA and controls and in active and inactive JIA. In addition, we explored whether treatment with tumor necrosis factor inhibitors (TNFi) affected the biomarker levels. Methods: This explorative, cross-sectional study comprised a subset of children and adolescents with non-systemic JIA and matched controls from the Norwegian juvenile idiopathic arthritis study (NorJIA Study). The JIA group included individuals with clinically active or inactive JIA. Serum and unstimulated saliva were analyzed using a multiplex assay of 92 inflammation-related biomarkers. Welch's t-test and Mann-Whitney U-test were used to analyze the differences in biomarker levels between JIA and controls and between active and inactive disease. Results: We included 42 participants with JIA and 30 controls, predominantly females, with a median age of 14 years. Of the 92 biomarkers, 87 were detected in serum, 73 in saliva, and 71 in both biofluids. A pronounced difference between serum and salivary biomarker patterns was found. Most biomarkers had higher levels in serum and lower levels in saliva in JIA versus controls, and in active versus inactive disease. In serum, TNF and S100A12 levels were notably higher in JIA and active disease. The TNF increase was less pronounced when excluding TNFi-treated individuals. In saliva, several biomarkers from the chemokine family were distinctly lower in the JIA group, and levels were even lower in active disease. Conclusion: In this explorative study, the serum and salivary biomarker patterns differed markedly, suggesting that saliva may not be a suitable substitute for serum when assessing systemic inflammation in JIA. Increased TNF levels in serum may not be a reliable biomarker for inflammatory activity in TNFi-treated children and adolescents with JIA. The lower levels of chemokines in saliva in JIA compared to controls and in active compared to inactive disease, warrant further investigation. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Adolescents; Biomarkers; Children; Disease activity; Inflammation; Juvenile idiopathic arthritis; Saliva; Serum |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240309 Date Completed: 20240311 Latest Revision: 20240312 |
| رمز التحديث: | 20240312 |
| مُعرف محوري في PubMed: | PMC10924355 |
| DOI: | 10.1186/s12969-024-00972-6 |
| PMID: | 38461338 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1546-0096 |
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| DOI: | 10.1186/s12969-024-00972-6 |