تقرير
Acute psychosis and behavioural changes with seizure-like hyperactive psychomotor activity secondary to isotretinoin initiation in a healthy young male: case report.
| العنوان: | Acute psychosis and behavioural changes with seizure-like hyperactive psychomotor activity secondary to isotretinoin initiation in a healthy young male: case report. |
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| المؤلفون: | Albalawi R; Department of Adult Neurology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia., Alsahli H; Department of Adult Neurology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia., Almutairi N; Department of Adult Neurology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia., Alhashemi M; Faculty of Medicine, University of Aleppo, Aleppo, Syria. |
| المصدر: | Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 Jan 15; Vol. 86 (3), pp. 1708-1710. Date of Electronic Publication: 2024 Jan 15 (Print Publication: 2024). |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Country of Publication: England NLM ID: 101616869 Publication Model: eCollection Cited Medium: Print ISSN: 2049-0801 (Print) Linking ISSN: 20490801 NLM ISO Abbreviation: Ann Med Surg (Lond) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [London] : Wolters Kluwer Original Publication: London : Surgical Associates Ltd., 2012- |
| مستخلص: | Introduction and Importance: Acute psychosis is a common brief psychiatric emergency period of delusions, hallucinations, disorganized thoughts and/or speech with or without psychomotor elements, which is not commonly induced by isotretinoin therapy. Dermatologists should counsel the patient before starting the treatment with all new, uncommon side effects, especially neuropsychiatric manifestations before starting this medication. Case Presentation: A 23-year-old male smoker with a known case of acne vulgaris recently started on isotretinoin for 2 weeks after which he developed abnormal hyperactive psychomotor activity. He was diagnosed with isoteritoin-induced acute psychosis based on clinical findings and exclusion, and valproic acid and olanzapine were initiated. The patient showed significant improvement. Clinical Discussion: Acute psychosis is a new, unfamiliar side effect presenting after initiation of isotretinoin therapy in young adults who were previously healthy. The mechanism is not well known but is thought to result from a decrease in the adult's neurogenesis or alterations in exposure of the serotonergic neurotransmitter system. Conclusion: Isotretinoin is commonly used nowadays for treating young adults. Patients and their families should be counselled about all the psychiatric side effects. Antipsychotics and antiepileptics with mood stabilizers may improve the acute status for patients with isotertoin-induced psychosis. Competing Interests: The authors declare that they have no competing interests.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.) |
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| فهرسة مساهمة: | Keywords: case report study; depression; isotretinoin; mental activity; psychiatric |
| تواريخ الأحداث: | Date Created: 20240311 Latest Revision: 20240312 |
| رمز التحديث: | 20240312 |
| مُعرف محوري في PubMed: | PMC10923358 |
| DOI: | 10.1097/MS9.0000000000001726 |
| PMID: | 38463077 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2049-0801 |
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| DOI: | 10.1097/MS9.0000000000001726 |