دورية أكاديمية
Diosgenin alleviates D-galactose-induced oxidative stress in rats' brain and liver targeting aging and apoptotic marker genes.
| العنوان: | Diosgenin alleviates D-galactose-induced oxidative stress in rats' brain and liver targeting aging and apoptotic marker genes. |
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| المؤلفون: | El-Far AH; Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Elghaity MM; Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Mohamed SA; Molecular Biology Unit, Medical Technology Centre, Medical Research Institute, Alexandria University, Alexandria, Egypt., Noreldin AE; Histology and Cytology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Elewa YHA; Department of Histology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.; Faculty of Veterinary Medicine, Basic Veterinary Sciences, Hokkaido University, Sapporo, Japan., Al Jaouni SK; Department of Hematology/Pediatric Oncology, Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Alsenosy AA; Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt. |
| المصدر: | Frontiers in molecular biosciences [Front Mol Biosci] 2024 Feb 23; Vol. 11, pp. 1303379. Date of Electronic Publication: 2024 Feb 23 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653173 Publication Model: eCollection Cited Medium: Print ISSN: 2296-889X (Print) Linking ISSN: 2296889X NLM ISO Abbreviation: Front Mol Biosci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2014]- |
| مستخلص: | The theory of aging is primarily concerned with oxidative stress caused by an imbalance in reactive oxygen species generation and cellular antioxidants. To alleviate the oxidative stress, we investigated the protective effect of diosgenin (DSG) for D-galactose (D-gal) using 20 and 40 mg of DSG/kg/day/orally for 42 days. The findings showed that D-gal caused brain and liver oxidative injuries by upregulating aging and oxidative markers. To counteract the oxidative stress caused by D-gal, DSG upregulated glutathione peroxidase-1, superoxide dismutase-1, and glutathione S-transferase-α. DSG also diminished the expression of p53 , p21 , Bcl-2-associated X protein, caspase-3, and mammalian target of rapamycin in brain and liver, as well as the build-up of β -galactosidase. DSG, in a dose-dependent manner, decreased the oxidative aging effects of D-gal in brain and liver tissues through targeting of aging and apoptotic marker genes. Finally, it should be noted that consuming DSG supplements is a suggesting natural preventative agent that may counteract aging and preserve health through improvement of body antioxidant status and control aging associated inflammation and cellular apoptosis. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 El-Far, Elghaity, Mohamed, Noreldin, Elewa, Al Jaouni and Alsenosy.) |
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| فهرسة مساهمة: | Keywords: aging; antioxidants; brain; diosgenin; liver; oxidative stress |
| تواريخ الأحداث: | Date Created: 20240311 Latest Revision: 20240312 |
| رمز التحديث: | 20240312 |
| مُعرف محوري في PubMed: | PMC10922004 |
| DOI: | 10.3389/fmolb.2024.1303379 |
| PMID: | 38463710 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-889X |
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| DOI: | 10.3389/fmolb.2024.1303379 |