التفاصيل البيبلوغرافية
| العنوان: |
Retinal blood flow association with age and weight in infants at risk for retinopathy of prematurity. |
| المؤلفون: |
Cho E; University of Maryland School of Medicine., Das U; University of Maryland School of Medicine., Sidelnikov D; University of Maryland School of Medicine., Balasubramanian T; University of Maryland School of Medicine., Shats D; University of Maryland School of Medicine., Mansoor S; University of Maryland School of Medicine., Forbes HE; University of Maryland School of Medicine., Zhou J; University of Maryland School of Medicine., Kapoor R; University of Maryland School of Medicine., Chase S; University of Maryland School of Medicine., Kore M; University of Maryland School of Medicine., Williams K; University of Maryland School of Medicine., Saeedi O; University of Maryland School of Medicine., Sundararajan S; University of Maryland School of Medicine., Levin MR; University of Maryland School of Medicine., Magder L; University of Maryland, Baltimore., Alexander J; University of Maryland School of Medicine. |
| المصدر: |
Research square [Res Sq] 2024 Feb 22. Date of Electronic Publication: 2024 Feb 22. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE |
| مستخلص: |
This prospective study evaluated the relationship between laser speckle contrast imaging (LSCI) ocular blood flow velocity (BFV) and five birth parameters: gestational age (GA), postmenstrual age (PMA), and chronological age (CA) at the time of measurement, birth weight (BW), and current weight (CW) in preterm neonates at risk for retinopathy of prematurity (ROP).38 Neonates with BW < 2 kg, GA < 32 weeks, and PMA between 27-47 weeks underwent 91 LSCI sessions. Correlation tests and regression analysis were performed to quantify relationships between birth parameters and ocular BFV. Mean ocular BFV index in this cohort was 8.8 +/- 4.0 IU. BFV positively correlated with PMA (r = 0.3, p = 0.01), CA (r = 0.3, p = 0.005), and CW (r = 0.3, p = 0.02). BFV did not correlate with GA nor BW (r=-0.2 and r=-0.05, p > 0.05). Regression analysis with mixed models demonstrated that BFV increased by 1.2 for every kilogram of CW, by 0.34 for every week of CA, and by 0.36 for every week of PMA (p = 0.03, 0.004, 0.007, respectively). Our findings indicate that increased age and weight are associated with increased ocular BFV measured using LSCI in premature infants. Future studies investigating the associations between ocular BFV and ROP clinical severity must control for age and/or weight of the infant.
Competing Interests: Dr. Alexander’s work has been funded by Maryland Industrial Partnerships (MIPS) Program (Grant 7103, funded in part by Vasoptic Medical). The remaining authors declare no competing interests. |
| التعليقات: |
Update in: Sci Rep. 2024 Jun 4;14(1):12790. doi: 10.1038/s41598-024-63534-6. (PMID: 38834830) |
| معلومات مُعتمدة: |
K23 EY032525 United States EY NEI NIH HHS; R43 EY030798 United States EY NEI NIH HHS; UL1 TR003098 United States TR NCATS NIH HHS |
| تواريخ الأحداث: |
Date Created: 20240311 Latest Revision: 20240617 |
| رمز التحديث: |
20240617 |
| مُعرف محوري في PubMed: |
PMC10925429 |
| DOI: |
10.21203/rs.3.rs-3909449/v1 |
| PMID: |
38464120 |
| قاعدة البيانات: |
MEDLINE |
