دورية أكاديمية
أعرض في EDS

Consanguineous Marriage and Its Association With Genetic Disorders in Saudi Arabia: A Review.

التفاصيل البيبلوغرافية
العنوان: Consanguineous Marriage and Its Association With Genetic Disorders in Saudi Arabia: A Review.
المؤلفون: Khayat AM; Pediatrics, College of Medicine, Taif University, Taif, SAU., Alshareef BG; Pediatrics, College of Medicine, Taif University, Taif, SAU., Alharbi SF; Biotechnology, College of Science, Taif University, Taif, SAU., AlZahrani MM; Family Medicine, College of Medicine, Taif University, Taif, SAU., Alshangity BA; Biotechnology, College of Science, Taif University, Taif, SAU., Tashkandi NF; Medical Research, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, SAU.
المصدر: Cureus [Cureus] 2024 Feb 09; Vol. 16 (2), pp. e53888. Date of Electronic Publication: 2024 Feb 09 (Print Publication: 2024).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Consanguineous marriages, where spouses are related by blood, have been a longstanding practice in human history. The primary medical concern with consanguineous marriages is the increased risk of genetic disorders. When closely related individuals reproduce, there is a higher probability that both parents carry the same genetic mutation. In Arab countries, especially Saudi Arabia, the rate of consanguineous marriage is high compared with Western European and Asian countries. This high rate is directly proportionate with elevated risk of genetic disorders, including congenital heart diseases, renal diseases, and rare blood disorders. Additionally, it was noted that the rate of negative postnatal outcomes is higher in consanguineous marriages compared with the general population. These observations indicate the necessity of tackling this area and highlighting the consequences of this practice. In this review, we aim to discuss the current evidence regarding the association between consanguineous marriages and genetic disorders in Saudi Arabia.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2024, Khayat et al.)
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فهرسة مساهمة: Keywords: congenital heart diseases (chds); consanguineous marriage; genetic disorders; renal diseases; saudi arabia
تواريخ الأحداث: Date Created: 20240311 Latest Revision: 20240312
رمز التحديث: 20240312
مُعرف محوري في PubMed: PMC10924896
DOI: 10.7759/cureus.53888
PMID: 38465157
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.53888