دورية أكاديمية
Relationships between obesity and functional outcome after ischemic stroke: a Mendelian randomization study.
| العنوان: | Relationships between obesity and functional outcome after ischemic stroke: a Mendelian randomization study. |
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| المؤلفون: | Lu J; Department of Neurology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, China.; Medical College of Soochow University, 199 Renai Road, Suzhou, 215123, China., Gong S; Department of Neurology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, China.; Medical College of Soochow University, 199 Renai Road, Suzhou, 215123, China., Zhu J; Department of Neurology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, China. zhujuehua0216@suda.edu.cn., Fang Q; Department of Neurology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, China. fangqi_008@126.com.; Department of Neurology, Dushu Lake Hospital Affiliated to Soochow University, 9 Chongwen Road, Suzhou, 215125, China. fangqi_008@126.com. |
| المصدر: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2024 Aug; Vol. 45 (8), pp. 3869-3877. Date of Electronic Publication: 2024 Mar 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milano, Italy : Springer-Verlag Italia, c2000- |
| مواضيع طبية MeSH: | Mendelian Randomization Analysis* , Obesity*/genetics , Obesity*/complications , Ischemic Stroke*/genetics , Waist-Hip Ratio* , Body Mass Index*, Humans ; Male ; Female ; Middle Aged ; Genetic Predisposition to Disease/genetics ; Aged ; Polymorphism, Single Nucleotide |
| مستخلص: | Background and Objectives: Most previous studies suggested obesity deteriorates the functional outcome after ischemic stroke. But there are researches claiming that obesity is associated with lower mortality, recurrence, and readmission rates, which is known as the obesity paradox. Our current research aimed to investigate the correlation between genetically obesity and the post-stroke outcome with the Mendelian randomization (MR) method. Methods: The UK Biobank and the GIANT consortium provided instrumental variables for body mass index (BMI, 806,834 individuals) and waist-to-hip ratio (WHR, 697,734 individuals). Data of functional outcome after ischemic stroke were obtained from the Genetics of Ischemic Stroke Functional Outcome network (6012 individuals). Inverse-variance weighted approach was utilized as the primary analyses. Sensitivity analyses involved the utilization of different MR methods. The heterogeneity among genetic variants was assessed by I 2 and Q value statistics. Results: In univariable analysis, there was a significant connection between genetic susceptibility to WHR and worse functional outcome (modified Rankin Scale 3) after ischemic stroke (OR [95%CI] = 1.47 [1.07, 2.02], P = 0.016). Genetic liability to BMI and was not associated with post-stroke functional outcome (all P > 0.05). The overall patterns between genetic liability to WHR and functional outcome post-ischemic outcome no longer existed in the multivariable MR analysis after adjusting for BMI (OR [95%CI] = 1.26[0.76,1.67], P = 0.56). Conclusion: The current MR study provided evidence that WHR was correlated to unfavorable outcome post-ischemic stroke. Exploring interventions against obesity may potentially improve recovery after ischemic stroke. (© 2024. Fondazione Società Italiana di Neurologia.) |
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| معلومات مُعتمدة: | 8271282 National Natural Science Foundation of China; 82071300 National Natural Science Foundation of China; GSWS2020002 Suzhou Gusu Medical Youth Talent; Qngg20210003 Suzhou Municipal Health Commission; SZYJTD201802 Suzhou Municipal Health Commission |
| فهرسة مساهمة: | Keywords: BMI; Mendelian randomization; Obesity; Post stroke outcome; WHR; WHRadjBMI |
| تواريخ الأحداث: | Date Created: 20240311 Date Completed: 20240717 Latest Revision: 20240717 |
| رمز التحديث: | 20240718 |
| DOI: | 10.1007/s10072-024-07415-w |
| PMID: | 38466476 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1590-3478 |
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| DOI: | 10.1007/s10072-024-07415-w |