دورية أكاديمية
Antinociceptive iridoid glycosides from the aerial parts of Paederia foetida .
| العنوان: | Antinociceptive iridoid glycosides from the aerial parts of Paederia foetida . |
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| المؤلفون: | Chen YF; Department of Nuclear Medicine, General Hospital of Northern Theater Command, Shenyang 110016, China., Gong W; Department of the Food and Drug Inspection, Shenyang Joint Logistics Support Center Drug Instrument Supervision and Inspection Station, Shenyang 110026, China., Zhao QJ; Department of Organic Chemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, China., Liu C; Department of Human Resource, General Hospital of Northern Theater Command, Shenyang 110016, China. |
| المصدر: | Journal of Asian natural products research [J Asian Nat Prod Res] 2024 Jul; Vol. 26 (7), pp. 788-794. Date of Electronic Publication: 2024 Mar 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Newark, N.J.?] : Harwood Academic Publishers, |
| مواضيع طبية MeSH: | Analgesics*/chemistry , Analgesics*/pharmacology , Analgesics*/isolation & purification , Iridoid Glycosides*/pharmacology , Iridoid Glycosides*/chemistry , Iridoid Glycosides*/isolation & purification , Plant Components, Aerial*/chemistry, Molecular Structure ; Animals ; Mice ; Nuclear Magnetic Resonance, Biomolecular ; Acetaminophen ; Aspirin/pharmacology ; Aspirin/chemistry ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/isolation & purification ; Male ; Stereoisomerism |
| مستخلص: | Two previously undescribed iridoid glycosides, 6'- O -trans-feruloyl-(4 S ,6 R )-3,4-dihydro-3 β -ethoxypaederoside ( 1 ) and 6'- O -trans-caffeoyl-(4 S ,6 R )-3,4-dihydro-2'- O -3 α -paederoside ( 2 ), were isolated from the 90% EtOH extract of the air dried aerial parts of Paederia Foetida . Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D ( 1 H - 1 H COSY, HMQC, and HMBC) NMR spectroscopy. The two isolated iridoid glycosides were tested in vivo for their antinociceptive properties. As a result, 2 showed potent antinociceptive effect and its ID |
| فهرسة مساهمة: | Keywords: Paederia foetida; Rubiaceae; antinociceptive activity; iridoid glycosides |
| المشرفين على المادة: | 0 (Analgesics) 0 (Iridoid Glycosides) 362O9ITL9D (Acetaminophen) R16CO5Y76E (Aspirin) 0 (Drugs, Chinese Herbal) |
| تواريخ الأحداث: | Date Created: 20240312 Date Completed: 20240612 Latest Revision: 20240612 |
| رمز التحديث: | 20240612 |
| DOI: | 10.1080/10286020.2024.2326565 |
| PMID: | 38469737 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1477-2213 |
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| DOI: | 10.1080/10286020.2024.2326565 |