دورية أكاديمية
Expression of monocyte chemokine receptors in diabetes after non-surgical periodontal treatment: A pilot study.
| العنوان: | Expression of monocyte chemokine receptors in diabetes after non-surgical periodontal treatment: A pilot study. |
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| المؤلفون: | Germano DB; Health Sciences Post Graduation, Santo Amaro University, Sao Paulo, Brazil., Silveira ALPA; Health Sciences Post Graduation, Santo Amaro University, Sao Paulo, Brazil., Kim YJ; Odontology Post Graduation, Santo Amaro University, Sao Paulo, Brazil., do Amaral JB; Federal University of Sao Paulo, ENT Research Laboratory, Otorhinolaryngology-Head and Neck Surgery Department, Sao Paulo, Brazil., Shio MT; Health Sciences Post Graduation, Santo Amaro University, Sao Paulo, Brazil., da Silva Nali LH; Health Sciences Post Graduation, Santo Amaro University, Sao Paulo, Brazil., Dos Santos Ferreira CE; Hospital Israelita Albert Einstein, Laboratorio Clínico, Sao Paulo, Brazil., Miyahira A; Odontology Post Graduation, Santo Amaro University, Sao Paulo, Brazil., Fonseca FAH; Federal University of Sao Paulo, Medicine Department, Cardiology Division, Sao Paulo, Brazil., Bachi ALL; Health Sciences Post Graduation, Santo Amaro University, Sao Paulo, Brazil., Pallos D; Odontology Post Graduation, Santo Amaro University, Sao Paulo, Brazil. Electronic address: dpallos@prof.unisa.br., França CN; Health Sciences Post Graduation, Santo Amaro University, Sao Paulo, Brazil. |
| المصدر: | Cytokine [Cytokine] 2024 Jun; Vol. 178, pp. 156579. Date of Electronic Publication: 2024 Mar 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001- > : Oxford : Elsevier Science Ltd. Original Publication: [Philadelphia, PA] : Saunders Scientific Publications, W.B. Saunders, [c1989- |
| مواضيع طبية MeSH: | Diabetes Mellitus*/metabolism , Periodontitis*/therapy , Periodontitis*/metabolism, Humans ; Monocytes/metabolism ; Pilot Projects ; Receptors, CCR2/genetics ; Receptors, CCR2/metabolism ; Receptors, CCR5/genetics ; Receptors, CCR5/metabolism ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/metabolism |
| مستخلص: | The aim of this study was to evaluate the effect of non-surgical periodontal treatment in the expression of chemokine receptors, in individuals with Periodontitis, associated or not with Diabetes. Pilot study, which included patients (n = 45) with Periodontitis, associated (n = 25) or not (n = 20) with Diabetes, submitted to the non-surgical periodontal treatment for one month. The expression of chemokine receptors CCR2, CCR5, and CX3CR1 at the mRNA level was evaluated in the peripheral mononuclear cells, as well as the expression of these receptors at the protein level was verified in monocyte subtypes (classical, intermediate, and non-classical monocytes). There was higher expression of CCR2 and CCR5 receptors at the initial visit in the group with Diabetes, with no differences for CX3CR1 (p = 0.002; p = 0.018, and p = 0.896, respectively), without differences after treatment. There was higher expression of CCR2 and CCR5 proteins in the group with Diabetes at the initial visit for classical, intermediate, and nonclassical monocytes, with no differences for CX3CR1 (CCR2: p = 0.004; p = 0.026; p = 0.024; CCR5: 0.045; p = 0.045; p = 0.013; CX3CR1: p = 0.424; p = 0.944; p = 0.392, respectively), without differences after the end of treatment. Concerning each group separately, there were reductions in the expression of CCR2 as well as CCR5 in classical, intermediate, and nonclassical monocytes, and reduction of CX3CR1 in classical monocytes after treatment in the group with Diabetes (p = 0.003; p = 0.006; p = 0.039; p = 0.007; p = 0.006; p = 0.004; p = 0.019, respectively), without differences in the group without Diabetes. The expression of the chemokine receptors CCR2 and CCR5, in patients with Periodontitis associated with Diabetes, is favorably modified after the end of the non-surgical periodontal treatment. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Diabetes; Periodontitis; Receptors |
| المشرفين على المادة: | 0 (Receptors, CCR2) 0 (Receptors, CCR5) 0 (CX3C Chemokine Receptor 1) |
| تواريخ الأحداث: | Date Created: 20240312 Date Completed: 20240412 Latest Revision: 20240605 |
| رمز التحديث: | 20240605 |
| DOI: | 10.1016/j.cyto.2024.156579 |
| PMID: | 38471419 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-0023 |
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| DOI: | 10.1016/j.cyto.2024.156579 |