دورية أكاديمية
أعرض في EDS

Using mycobacterium cell wall fraction to decrease equine chorionic gonadotropin after abortion.

التفاصيل البيبلوغرافية
العنوان: Using mycobacterium cell wall fraction to decrease equine chorionic gonadotropin after abortion.
المؤلفون: Fedorka CE; Department of Veterinary Sciences, University of Kentucky, Lexington, Kentucky, USA.; Department of Animal Sciences, Colorado State University, Fort Collins, Colorado, USA., Schnobrich MR; Rood & Riddle Equine Hospital, Lexington, Kentucky, USA., Muderspach ND; Department of Veterinary Clinical Sciences, University of Copenhagen, Copenhagen, Denmark., Scoggin KE; Department of Veterinary Sciences, University of Kentucky, Lexington, Kentucky, USA., Dedman MT; Lincoln Memorial College of Veterinary Medicine, Harrogate, Tennessee, USA., Weigle KE; Lincoln Memorial College of Veterinary Medicine, Harrogate, Tennessee, USA., May MG; Lincoln Memorial College of Veterinary Medicine, Harrogate, Tennessee, USA., Twist H; Rood & Riddle Equine Hospital, Lexington, Kentucky, USA., Linse CR; Rood & Riddle Equine Hospital, Lexington, Kentucky, USA., Douglas RH; BET Laboratories, Lexington, Kentucky, USA., Troedsson MHT; Department of Veterinary Sciences, University of Kentucky, Lexington, Kentucky, USA.
المصدر: Equine veterinary journal [Equine Vet J] 2024 Jul; Vol. 56 (4), pp. 806-814. Date of Electronic Publication: 2024 Mar 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0173320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-3306 (Electronic) Linking ISSN: 04251644 NLM ISO Abbreviation: Equine Vet J Subsets: MEDLINE
أسماء مطبوعة: Publication: <2009- > : Hobokken, NJ : Wiley
Original Publication: Newmarket, Suffolk : Equine Veterinary Journal, Ltd
مواضيع طبية MeSH: Mycobacterium* , Chorionic Gonadotropin*/pharmacology , Chorionic Gonadotropin*/administration & dosage , Abortion, Veterinary*, Animals ; Horses ; Female ; Pregnancy ; Horse Diseases ; Cytokines/metabolism
مستخلص: Background: Equine embryonic loss following the development of endometrial cups delays return to cyclicity due to the production of equine chorionic gonadotropin (eCG). Natural degradation of endometrial cups coincides with an influx of immune cells at 100-120 days of gestation, but therapeutic stimulation of reduced eCG production has been relatively unsuccessful. Recently, we observed an increase in pro-inflammatory cytokine production following the use of the immunostimulant mycobacterium cell wall fraction (MCWF).
Objectives: To evaluate the efficacy of hysteroscopic-guided injection of MCWF on the accelerated decline of eCG secretion.
Study Design: In vivo experiment.
Methods: Mares were pharmacologically aborted at 40-45 days of gestation, and then divided into groups: MCWF-treated (6 mg MCWF suspended in 20 mL LRS; n = 10) and Control (20 mL LRS; n = 6). Five days after abortion, hysteroscopic-guided injection of endometrial cups was performed, with 1 mL of volume placed into each visible endometrial cup. This was repeated 7 days later. Trans-rectal ultrasonography was performed to monitor ovarian activity, and serum was obtained to assess eCG and cytokine concentrations.
Results: Concentrations of eCG decreased in the MCWF-treated group (p < 0.01) with a significant suppression noted as early as 14 days after onset of treatment and remained suppressed for the duration of the study. This coincided with an increase in peripheral IFN-γ (p < 0.01) and IL-1β (p < 0.01) concentrations. Eight out of ten MCWF-treated mares (80%) developed pre-ovulatory follicles, in comparison to 2/6 controls (33%). A pre-ovulatory follicle was noted 23 ± 4 days after onset of treatment.
Main Limitations: No pregnancy data was obtained following treatment.
Conclusions: This is the first report of a treatment for the accelerated reduction of eCG following abortion. Stimulation of this process allowed mares to develop a pre-ovulatory follicle within a month of MCWF treatment onset, granting repeat attempts at breeding within the confines of a single breeding season.
(© 2024 The Authors. Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.)
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فهرسة مساهمة: Keywords: endometrial cups; equine abortion; equine chorionic gonadotropin; horse; immunomodulation
المشرفين على المادة: 0 (Chorionic Gonadotropin)
0 (Cytokines)
تواريخ الأحداث: Date Created: 20240312 Date Completed: 20240605 Latest Revision: 20240605
رمز التحديث: 20240606
DOI: 10.1111/evj.14079
PMID: 38472105
قاعدة البيانات: MEDLINE
الوصف
تدمد:2042-3306
DOI:10.1111/evj.14079