دورية أكاديمية
أعرض في EDS

Differential Upregulation of Th1/Th17-Associated Proteins and PD-L1 in Granulomatous Mycosis Fungoides.

التفاصيل البيبلوغرافية
العنوان: Differential Upregulation of Th1/Th17-Associated Proteins and PD-L1 in Granulomatous Mycosis Fungoides.
المؤلفون: Marques-Piubelli ML; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Navarrete J; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ledesma DA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hudgens CW; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lazcano RN; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Alani A; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Huen A; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Duvic M; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Nagarajan P; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Aung PP; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wistuba II; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Curry JL; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Miranda RN; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Torres-Cabala CA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
المصدر: Cells [Cells] 2024 Feb 27; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Skin Neoplasms*/pathology , Mycosis Fungoides*/pathology, Humans ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; B7-H1 Antigen/metabolism ; Up-Regulation ; Programmed Cell Death 1 Receptor/metabolism ; Glia Maturation Factor/metabolism ; Forkhead Transcription Factors/metabolism
مستخلص: Granulomatous Mycosis Fungoides (GMF) is a rare form of mycosis fungoides (MF) characterized by a granulomatous infiltrate associated with the neoplastic lymphoid population and is considered to have a worse prognosis compared with regular MF. The upregulation of the T helper (Th) axis, especially Th17, plays an important role in the pathogenesis of several inflammatory/infectious granulomatous cutaneous diseases, but its role in GMF is still not elucidated to date. In this study, we evaluated the immunohistochemical expression of Th1 (Tbet), Th2 (GATA-3), Th17 (RORγT), T regulatory (Foxp3), and immune checkpoint (IC) (PD-1 and PD-L1) markers in a cohort of patients with GMF and MF with large cell transformation (MFLCT). Skin biopsies from 49 patients (28 GMF and 21 MFLCT) were studied. Patients with GMF were associated with early clinical stage ( p = 0.036) and lower levels of lactate dehydrogenase ( p = 0.042). An increased percentage of cells positive for Tbet ( p = 0.017), RORγT ( p = 0.001), and PD-L1 ( p = 0.011) was also observed among the GMF specimens, while a stronger PD-1 intensity was detected in cases of MFLCT. In this cohort, LCT, RORγT < 10%, Foxp3 < 10%, age, and advanced stage were associated with worse overall survival (OS) in univariate analysis. GMF demonstrated Th1 (cellular response) and Th17 (autoimmunity) phenotype, seen in early MF and granulomatous processes, respectively, which may be related to the histopathological appearance and biological behavior of GMF. Further studies involving larger series of cases and more sensitive techniques are warranted.
References: Acta Derm Venereol. 2022 Sep 21;102:adv00777. (PMID: 35971833)
Front Oncol. 2021 Aug 16;11:733770. (PMID: 34485162)
N Engl J Med. 2017 May 18;376(20):1989-91. (PMID: 28514612)
J Am Acad Dermatol. 2013 Sep;69(3):366-74. (PMID: 23685027)
J Pathol. 2004 Feb;202(2):164-71. (PMID: 14743498)
Pathology. 2014 Dec;46(7):610-6. (PMID: 25393251)
Cell Mol Immunol. 2019 Jul;16(7):634-643. (PMID: 30867582)
Blood Rev. 2016 Mar;30(2):89-100. (PMID: 26319391)
Blood Adv. 2021 Feb 9;5(3):771-774. (PMID: 33560388)
Cancers (Basel). 2023 Jan 25;15(3):. (PMID: 36765704)
Int J Clin Exp Pathol. 2019 Jul 01;12(7):2772-2774. (PMID: 31934112)
Diagn Histopathol (Oxf). 2016 Apr;22(4):142-151. (PMID: 29225700)
Blood. 2019 Dec 12;134(24):2159-2170. (PMID: 31562134)
JAAD Case Rep. 2015 Jul 31;1(5):298-302. (PMID: 27051759)
Clin Lymphoma Myeloma Leuk. 2016 Jan;16(1):49-56. (PMID: 26702474)
Ital J Dermatol Venerol. 2022 Aug;157(4):355-362. (PMID: 35373781)
Pathologe. 2015 Feb;36(1):62-9. (PMID: 25589355)
Arch Dermatol. 2008 Dec;144(12):1609-17. (PMID: 19075143)
Oncoimmunology. 2020 Feb 26;9(1):1731942. (PMID: 32158624)
Rheumatology (Oxford). 2012 Jan;51(1):37-46. (PMID: 22075064)
Br J Dermatol. 1994 Aug;131(2):275-9. (PMID: 7917995)
J Dermatol Sci. 2018 Jan;89(1):88-91. (PMID: 29030090)
Ann Transl Med. 2020 Nov;8(22):1526. (PMID: 33313271)
J Clin Oncol. 2020 Jan 1;38(1):20-28. (PMID: 31532724)
An Bras Dermatol. 2015 Jul-Aug;90(4):554-6. (PMID: 26375225)
Front Immunol. 2014 Dec 16;5:630. (PMID: 25566245)
J Cutan Pathol. 2013 Feb;40(2):284-5. (PMID: 22994978)
Blood. 2014 May 8;123(19):2915-23. (PMID: 24632715)
Front Immunol. 2017 Aug 21;8:949. (PMID: 28871251)
Eur J Cancer. 2021 Oct;156 Suppl 1:S69-S70. (PMID: 34649669)
J Eur Acad Dermatol Venereol. 2009 Jun;23(6):639-47. (PMID: 19207677)
Thorax. 2011 Feb;66(2):144-50. (PMID: 21139119)
J Cutan Pathol. 2010 Oct;37(10):1072-6. (PMID: 20579213)
Clin Cancer Res. 2011 Dec 15;17(24):7529-38. (PMID: 22048239)
Blood. 2013 Aug 8;122(6):943-50. (PMID: 23801634)
Am J Dermatopathol. 2022 Aug 1;44(8):559-567. (PMID: 35476045)
فهرسة مساهمة: Keywords: T helper; Th1; Th17; granulomatous mycosis fungoides
المشرفين على المادة: 0 (Nuclear Receptor Subfamily 1, Group F, Member 3)
0 (B7-H1 Antigen)
0 (Programmed Cell Death 1 Receptor)
0 (Glia Maturation Factor)
0 (Forkhead Transcription Factors)
تواريخ الأحداث: Date Created: 20240313 Date Completed: 20240314 Latest Revision: 20240315
رمز التحديث: 20240315
مُعرف محوري في PubMed: PMC10931377
DOI: 10.3390/cells13050419
PMID: 38474383
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells13050419