دورية أكاديمية
Correlation of progesterone receptors and P63 to the histological grade of meningiomas: Review and significance in an African population.
| العنوان: | Correlation of progesterone receptors and P63 to the histological grade of meningiomas: Review and significance in an African population. |
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| المؤلفون: | Eluke CC; Department of Morbid Anatomy, College of Medicine, University of Nigeria, Enugu, Nigeria., Aniume OI; Department of Morbid Anatomy, College of Medicine, University of Nigeria, Enugu, Nigeria., Olusina BD; Department of Morbid Anatomy, College of Medicine, University of Nigeria, Enugu, Nigeria., Okafor OC; Department of Morbid Anatomy, College of Medicine, University of Nigeria, Enugu, Nigeria., Olasode BJ; Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria. |
| المصدر: | Journal of neurosciences in rural practice [J Neurosci Rural Pract] 2024 Jan-Mar; Vol. 15 (1), pp. 69-73. Date of Electronic Publication: 2023 Sep 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Scientific Scholar Country of Publication: United States NLM ID: 101533710 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0976-3147 (Print) Linking ISSN: 09763155 NLM ISO Abbreviation: J Neurosci Rural Pract Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Pittsford, NY : Scientific Scholar Original Publication: Mumbai : Medknow Publications and Media Pvt. Ltd. |
| مستخلص: | Objectives: Meningiomas, a common neoplasm of the central nervous system, is a widely studied meningeal tumor. According to the World Health Organization (WHO) 2021 classification of meningiomas, there are 15 subtypes that have been grouped into grades 1, 2, and 3. The WHO grade 1 meningiomas are generally grouped as benign while the WHO grades 2 and 3 tumors are grouped as malignant. Progesterone receptors and P63 are common immunohistochemical markers that have proven useful in the diagnosis, grading, and prognostication of many neoplasms such as breast carcinoma, prostate carcinoma, and gastrointestinal tumors in histopathology practice. The application of these immunohistochemical markers to the grading of meningiomas has been reported and their usefulness documented in reports from Africa, Europe, North America, South America, and Asia. This study, therefore, seeks to determine if these findings are applicable to the meningiomas seen in an African population. Materials and Methods: A 10-year review of results and histologically diagnosed cases of meningiomas received in the Department of Morbid Anatomy, University of Nigeria, Enugu. Immunostaining for progesterone receptors (PgRs) and P63 were done and results compared with histologic grades. Results: The three WHO grades of meningioma were assessed in this study. M: F ratio was 1:1.4 and peak age was 41-50 years age range (SD ± 16.54). The majority of the cases were WHO grade 1 (86.1%) while the WHO grades 2 and 3 tumors were 8% and 5.9%, respectively. The fibrous variant was the most common subtype (27.1%). There was no correlation between progesterone receptor and P63 immunopositivity to the WHO grades of meningioma ( P = 0.112 and P = 0.138, respectively). Conclusion: Our study showed that progesterone receptors and P63 immunopositivity did not correlate with the WHO grades of meningiomas. This may be due to the predominant variant of meningioma seen in this study. These findings indicate that PgR antagonist may not be an effective alternative for treatment in patients with inoperable meningiomas. Furthermore, P63 immunopositivity may not be a sufficient grading tool for managing meningiomas in our population. Competing Interests: There are no conflicts of interest. (© 2024 Published by Scientific Scholar on behalf of Journal of Neurosciences in Rural Practice.) |
| References: | Cell Stem Cell. 2009 Jul 2;5(1):64-75. (PMID: 19570515) Folia Neuropathol. 2016;54(2):114-26. (PMID: 27543769) Neuro Oncol. 2017 Nov 6;19(suppl_5):v1-v88. (PMID: 29117289) Afr Health Sci. 2018 Jun;18(2):281-286. (PMID: 30602954) Acta Neurochir (Wien). 1992;115(1-2):20-30. (PMID: 1595392) Int J Surg Pathol. 2012 Aug;20(4):349-54. (PMID: 22287651) Front Neuroendocrinol. 2008 May;29(2):313-39. (PMID: 18374402) Niger Postgrad Med J. 2018 Jan-Mar;25(1):17-20. (PMID: 29676340) Neurosurg Rev. 2004 Oct;27(4):238-45. (PMID: 15168138) Int J Surg Pathol. 2008 Jan;16(1):38-42. (PMID: 18203782) J Neuropathol Exp Neurol. 2017 Apr 1;76(4):289-298. (PMID: 28340171) Cancers (Basel). 2023 Feb 03;15(3):. (PMID: 36765937) Stem Cells. 2011 Nov;29(11):1672-83. (PMID: 21898690) Folia Neuropathol. 2006;44(2):111-5. (PMID: 16823693) World Neurosurg. 2020 Jun;138:e361-e369. (PMID: 32142947) Neuropathology. 2010 Feb 1;30(1):44-9. (PMID: 19703265) |
| فهرسة مساهمة: | Keywords: Africa; Central nervous system tumors; Meningioma; P63; Progesterone receptors |
| تواريخ الأحداث: | Date Created: 20240313 Latest Revision: 20240314 |
| رمز التحديث: | 20240314 |
| مُعرف محوري في PubMed: | PMC10927058 |
| DOI: | 10.25259/JNRP_332_2023 |
| PMID: | 38476431 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0976-3147 |
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| DOI: | 10.25259/JNRP_332_2023 |