دورية أكاديمية
The causes of bacterial bloodstream infections and antimicrobial resistance patterns in children attending a secondary care hospital in Bhaktapur, Nepal, 2017-2022: a retrospective study.
| العنوان: | The causes of bacterial bloodstream infections and antimicrobial resistance patterns in children attending a secondary care hospital in Bhaktapur, Nepal, 2017-2022: a retrospective study. |
|---|---|
| المؤلفون: | Shrestha RK; Department of Research, Siddhi Memorial Hospital, Bhaktapur, Nepal., Shrestha D; Department of Research, Siddhi Memorial Hospital, Bhaktapur, Nepal., Sah AK; Department of Research, Siddhi Memorial Hospital, Bhaktapur, Nepal., Thapa A; Department of Research, Siddhi Memorial Hospital, Bhaktapur, Nepal., Shrestha N; Department of Research, Siddhi Memorial Hospital, Bhaktapur, Nepal., Raya GB; Department of Research, Siddhi Memorial Hospital, Bhaktapur, Nepal., Furushima K; School of Tropical Medicine and Global Health (TMGH), Nagasaki University, Nagasaki, Japan., Dhoubhadel BG; School of Tropical Medicine and Global Health (TMGH), Nagasaki University, Nagasaki, Japan.; Department of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan., Parry CM; School of Tropical Medicine and Global Health (TMGH), Nagasaki University, Nagasaki, Japan.; Clinical Sciences and Education, Liverpool School of Tropical Medicine, Liverpool, UK. |
| المصدر: | JAC-antimicrobial resistance [JAC Antimicrob Resist] 2024 Mar 12; Vol. 6 (2), pp. dlae035. Date of Electronic Publication: 2024 Mar 12 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101765283 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1823 (Electronic) Linking ISSN: 26321823 NLM ISO Abbreviation: JAC Antimicrob Resist Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : Oxford University Press, [2019]- |
| مستخلص: | Objectives: Data on antimicrobial resistance (AMR) among children in Nepal are limited. Here we have characterized the causes of bacterial bloodstream infections (BSIs), antimicrobial resistance patterns and the mechanisms of β-lactamase production in Enterobacterales among children attending outpatient and inpatient departments of a secondary care paediatric hospital in Nepal. Methods: We retrospectively collected demographic and clinical data of culture-proven bacterial BSIs between January 2017 and December 2022 among children <18 years attending a 50-bedded paediatric hospital. Stored isolates were subcultured for antimicrobial susceptibility testing against commonly used antimicrobials. Enterobacterales displaying non-susceptibility to β-lactams were phenotypically and genotypically investigated for ESBLs, plasmid-mediated AmpC (pAmpC) β-lactamases and carbapenemases. Results: A total of 377 significant bacteria were isolated from 27 366 blood cultures. Among 91 neonates with a BSI, Klebsiella pneumoniae ( n = 39, 42.4 % ), Pseudomonas aeruginosa ( n = 15, 16.3%) and Acinetobacter baumannii complex ( n = 13, 14.1%) were most common. In the non-neonates, 275/285 (96.5%) infections were community-acquired including Staphylococcus aureus ( n = 89, 32.4%), Salmonella Typhi ( n = 54, 19.6%) and Streptococcus pneumoniae ( n = 32, 11.6%). Among the 98 S. aureus , 29 (29.6%) were methicillin-resistant Staphylococcus aureus . K. pneumoniae and Escherichia coli demonstrated non-susceptibility to extended-spectrum cephalosporins and carbapenems in both community and hospital-acquired cases. For E. coli and K. pneumoniae , bla Conclusions: We determined significant levels of AMR among children attending a secondary care paediatric hospital with BSI in Nepal. Nationwide surveillance and implementation of antimicrobial stewardship policies are needed to combat the challenge imposed by AMR. (© The Author(s) 2024. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.) |
| References: | J Clin Microbiol. 2002 Jun;40(6):2153-62. (PMID: 12037080) Antimicrob Agents Chemother. 2007 Nov;51(11):4015-21. (PMID: 17724160) Lancet Glob Health. 2022 Sep;10(9):e1317-e1325. (PMID: 35961355) Lancet. 2022 Feb 12;399(10325):629-655. (PMID: 35065702) PLoS Med. 2023 Jun 8;20(6):e1004179. (PMID: 37289666) Infect Drug Resist. 2021 Jun 14;14:2201-2212. (PMID: 34163185) Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0067521. (PMID: 34181474) J Hosp Infect. 2023 Mar;133:98-99. (PMID: 36657491) BMC Infect Dis. 2021 Jun 9;21(1):546. (PMID: 34107906) Lancet Infect Dis. 2020 Feb;20(2):179-187. (PMID: 31843383) Infect Drug Resist. 2020 Nov 24;13:4249-4261. (PMID: 33262619) J Antimicrob Chemother. 2017 Jan;72(1):166-171. (PMID: 27703058) Infect Dis (Auckl). 2020 Feb 27;13:1178633720909798. (PMID: 32158219) BMC Med. 2019 Mar 29;17(1):70. (PMID: 30922309) J Antimicrob Chemother. 2010 Mar;65(3):490-5. (PMID: 20071363) Lancet Microbe. 2022 Dec;3(12):e922-e930. (PMID: 36335953) Ann Clin Microbiol Antimicrob. 2020 Oct 21;19(1):48. (PMID: 33087115) Clin Microbiol Infect. 2012 Mar;18(3):268-81. (PMID: 21793988) BMC Res Notes. 2018 May 15;11(1):301. (PMID: 29764503) Emerg Infect Dis. 2018 May;24(5):841-851. (PMID: 29664370) Diagn Microbiol Infect Dis. 2011 May;70(1):119-23. (PMID: 21398074) Clin Microbiol Rev. 2020 Jun 10;33(3):. (PMID: 32522747) Front Med (Lausanne). 2018 Sep 19;5:262. (PMID: 30283784) Int J Infect Dis. 2021 Feb;103:48-55. (PMID: 33217574) Antimicrob Resist Infect Control. 2017 Jun 15;6:67. (PMID: 28638594) |
| تواريخ الأحداث: | Date Created: 20240313 Latest Revision: 20240314 |
| رمز التحديث: | 20240314 |
| مُعرف محوري في PubMed: | PMC10928669 |
| DOI: | 10.1093/jacamr/dlae035 |
| PMID: | 38476771 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2632-1823 |
|---|---|
| DOI: | 10.1093/jacamr/dlae035 |