دورية أكاديمية
Trans-Spinal Theta Burst Magnetic Stimulation in Parkinson's Disease and Gait Disorders.
| العنوان: | Trans-Spinal Theta Burst Magnetic Stimulation in Parkinson's Disease and Gait Disorders. |
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| المؤلفون: | Menezes JR; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil., Nunes GA; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil., Carra RB; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil., da Silva Simões J; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil., Solla DJF; Functional Neurosurgery Division, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil., Oliveira JR; Department of Phytotherapy, Speech Therapy and Occupational Therapy, School of Medicine, University of São Paulo, São Paulo, Brazil., Teixeira MJ; Functional Neurosurgery Division, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil., Marcolin MA; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil., Barbosa ER; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil., Tanaka C; Department of Phytotherapy, Speech Therapy and Occupational Therapy, School of Medicine, University of São Paulo, São Paulo, Brazil., de Andrade DC; Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark., Cury RG; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil.; Hospital Israelita Albert Einstein, São Paulo, Brazil. |
| المصدر: | Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2024 Jun; Vol. 39 (6), pp. 1048-1053. Date of Electronic Publication: 2024 Mar 13. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001->: New York, NY : Wiley-Liss Original Publication: [New York, N.Y.] : Raven Press, [c1986- |
| مواضيع طبية MeSH: | Parkinson Disease*/complications , Parkinson Disease*/therapy , Parkinson Disease*/physiopathology , Gait Disorders, Neurologic*/etiology , Gait Disorders, Neurologic*/therapy , Gait Disorders, Neurologic*/physiopathology, Humans ; Male ; Female ; Aged ; Middle Aged ; Double-Blind Method ; Postural Balance/physiology ; Treatment Outcome ; Quality of Life ; Spinal Cord Stimulation/methods ; Transcranial Magnetic Stimulation/methods ; Gait/physiology ; Magnetic Field Therapy/methods |
| مستخلص: | Background: Gait disorders in patients with Parkinson's disease (PD) can become disabling with disease progression without effective treatment. Objectives: To investigate the efficacy of intermittent θ burst trans-spinal magnetic stimulation (TsMS) in PD patients with gait and balance disorders. Methods: This was a randomized, parallel, double-blind, controlled trial. Active or sham TsMS was applied at third thoracic vertebra with 100% of the trans-spinal motor threshold, during 5 consecutive days. Participants were evaluated at baseline, immediately after last session, 1 and 4 weeks after last session. Primary outcome was Total Timed Up and Go (TUG) values comparing active versus sham phases 1 week after intervention. The secondary outcome measurements consisted of motor, gait and balance scales, and questionnaires for quality of life and cognition. Results: Thirty-three patients were included, average age 68.5 (6.4) years in active group and 70.3 (6.3) years in sham group. In active group, Total TUG mean baseline was 107.18 (95% CI, 52.1-116.1), and 1 week after stimulation was 93.0 (95% CI, 50.7-135.3); sham group, Total TUG mean baseline was 101.2 (95% CI, 47.1-155.3) and 1 week after stimulation 75.2 (95% CI 34.0-116.4), P = 0.54. Similarly, intervention had no significant effects on secondary outcome measurements. During stimulation period, five patients presented with mild side effects (three in active group and two in sham group). Discussion: TsMS did not significantly improve gait or balance analysis in patients with PD and gait disorders. The protocol was safe and well tolerated. © 2024 International Parkinson and Movement Disorder Society. (© 2024 International Parkinson and Movement Disorder Society.) |
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| معلومات مُعتمدة: | Foundation for Research Support of the State of São Paulo, Process 2019/11000-8 |
| فهرسة مساهمة: | Keywords: Parkinson's disease/parkinsonism; all spinal cord; gait disturbance/ataxia; surgery/stimulation |
| تواريخ الأحداث: | Date Created: 20240313 Date Completed: 20240626 Latest Revision: 20240626 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1002/mds.29776 |
| PMID: | 38477413 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1531-8257 |
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| DOI: | 10.1002/mds.29776 |