دورية أكاديمية
Expression of CD25, mast cell markers and T-cell markers in eosinophilic esophagitis.
| العنوان: | Expression of CD25, mast cell markers and T-cell markers in eosinophilic esophagitis. |
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| المؤلفون: | Htoo A; Department of Pathology, Albany Medical Center, Albany, NY, USA., Qualia CM; Department of Pediatrics, Albany Medical Center, Albany, NY, USA., George R; Department of Pathology, Albany Medical Center, Albany, NY, USA., Arker SH; Department of Pathology, Albany Medical Center, Albany, NY, USA., Subasi NB; Department of Pathology, Albany Medical Center, Albany, NY, USA., Lee H; Department of Pathology, Albany Medical Center, Albany, NY, USA., Chung L; Department of Pathology, Albany Medical Center, Albany, NY, USA., Chen A; Department of Pathology, Albany Medical Center, Albany, NY, USA; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: canne@wustl.edu. |
| المصدر: | Annals of diagnostic pathology [Ann Diagn Pathol] 2024 Jun; Vol. 70, pp. 152287. Date of Electronic Publication: 2024 Mar 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Co Country of Publication: United States NLM ID: 9800503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8198 (Electronic) Linking ISSN: 10929134 NLM ISO Abbreviation: Ann Diagn Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : W.B. Saunders Co., c1997- |
| مواضيع طبية MeSH: | Eosinophilic Esophagitis*/pathology , Eosinophilic Esophagitis*/metabolism , Eosinophilic Esophagitis*/diagnosis , Mast Cells*/pathology , Mast Cells*/metabolism , Interleukin-2 Receptor alpha Subunit*/metabolism , Biomarkers*/metabolism , T-Lymphocytes*/pathology , T-Lymphocytes*/metabolism , Eosinophils*/pathology , Eosinophils*/metabolism, Humans ; Male ; Female ; Adult ; Immunohistochemistry/methods ; Biopsy ; Middle Aged ; Child ; Adolescent ; Tryptases/metabolism ; Young Adult ; Esophagus/pathology ; Esophagus/metabolism ; Child, Preschool |
| مستخلص: | While eosinophilic esophagitis (EOE) is defined by histologic presence of eosinophils, a few studies have established the presence of mast cells in EOE and even shown their correlation with symptom persistence despite resolution of eosinophils. Expression of aberrant mast cell markers CD25 and CD2 have not been studied in EOE. This study quantifies the number of hotspot cells per high power field expressing CKIT/CD117, tryptase, CD25, CD2 and CD3 by immunohistochemical stains in endoscopic esophageal biopsies of the following three cohorts: (1) established and histologically confirmed EOE, (2) suspected EOE with biopsies negative for eosinophils, and (3) no history of or suspicion for EOE with histologically unremarkable biopsies. In this study, mast cells were highlighted by CKIT and tryptase in EOE, and not seen in other clinically mimicking cases. There were also significantly higher densities of CD25 and pan-T-cell marker staining in EOE cases. These findings suggest an inflammatory cellular milieu in EOE, beyond just eosinophils, that can be demonstrated by immunohistochemistry, and that invite further study into the role that these cells may play in EOE. Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: CD117; CD25; CKIT; Eosinophilic esophagitis; Mast cells; Tryptase |
| المشرفين على المادة: | 0 (Interleukin-2 Receptor alpha Subunit) 0 (Biomarkers) 0 (IL2RA protein, human) EC 3.4.21.59 (Tryptases) |
| تواريخ الأحداث: | Date Created: 20240313 Date Completed: 20240425 Latest Revision: 20240429 |
| رمز التحديث: | 20240429 |
| DOI: | 10.1016/j.anndiagpath.2024.152287 |
| PMID: | 38479198 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-8198 |
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| DOI: | 10.1016/j.anndiagpath.2024.152287 |