دورية أكاديمية
أعرض في EDS

TGFβ signaling pathway in salivary gland tumors.

التفاصيل البيبلوغرافية
العنوان: TGFβ signaling pathway in salivary gland tumors.
المؤلفون: Gomes ÁNM; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo, Brazil., Oliveira KK; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil., Marchi FA; Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil; Center for Translational Research in Oncology, Cancer Institute of the State of São Paulo (ICESP), São Paulo, Brazil., Bettim BB; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil., Germano JN; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil., Gonçalves Filho J; Department of Head and Neck Surgery and Otorhinolaringology, A.C.Camargo Cancer Center, São Paulo, Brazil., Pinto CAL; Department of Anatomic Pathology, A.C.Camargo Cancer Center, São Paulo, Brazil., Lourenço SV; Department of General Pathology, Dental School, University of São Paulo, São Paulo, Brazil., Coutinho-Camillo CM; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo, Brazil. Electronic address: ccamillo@accamargo.org.br.
المصدر: Archives of oral biology [Arch Oral Biol] 2024 Jun; Vol. 162, pp. 105943. Date of Electronic Publication: 2024 Mar 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0116711 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1506 (Electronic) Linking ISSN: 00039969 NLM ISO Abbreviation: Arch Oral Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Pergamon Press
Original Publication: Oxford, New York [etc.] Pergamon Press.
مواضيع طبية MeSH: Adenoma, Pleomorphic*/genetics , Adenoma, Pleomorphic*/metabolism , Adenoma, Pleomorphic*/pathology , Carcinoma, Adenoid Cystic*/genetics , Carcinoma, Adenoid Cystic*/metabolism , Carcinoma, Mucoepidermoid*/metabolism , Salivary Gland Neoplasms*/genetics , Salivary Gland Neoplasms*/metabolism , Transforming Growth Factor beta*/metabolism, Humans ; Biomarkers, Tumor/metabolism ; Signal Transduction
مستخلص: Objective: Pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC), and adenoid cystic carcinoma (ACC) are the most prevalent salivary gland tumors. Their pathogenesis has been recently associated with complex molecular cascades, including the TGFβ signaling pathway. The aim of this study was to evaluate the expression of genes associated with the TGFβ signaling pathway (TGFB1, ITGB6, SMAD2, SMAD4, FBN1, LTBP1, and c-MYC) to map possible downstream alterations in the TGFβ cascade.
Design: Thirteen PA, 17 MEC, 13 ACC, and 10 non-neoplastic salivary gland samples were analyzed by real-time RT-PCR.
Results: Cases of PA presented increased TGFB1, LTPB1, c-MYC, and FBN1 expressions, whereas SMAD2 expression was decreased when compared to non-neoplastic tissue. MEC patients displayed increased expressions of TGFB1, ITGB6, FBN1, and c-MYC and decreased expressions of SMAD2 and SMAD4. ACC cases exhibited elevated expressions of the investigated genes except TGFB1. The present results suggest that decreased expression of SMAD2 and SMAD4 does not impede the transcriptional regulation of c-MYC, especially in PA and MEC. Increased expressions of ITGB6, TGFB1, LTBP1, and FBN1 appear to be related to the regulation of the TGFβ signaling pathway in these tumors. Additionally, we observed a higher expression of SMAD4 in ACC and a raised expression of ITGB6 and lowered expression of SMAD2 in MEC.
Conclusions: Our study demonstrated the differential expression of TGFβ cascade members in salivary gland tumors such as SMAD2/SMAD4 and c-MYC as well as the participation of ITGB6, TGFB1, LTBP1, and FBN1, contributing to the understanding of the mechanisms involved in tumor progression.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Adenoid cystic carcinoma; Mucoepidermoid carcinoma; Pleomorphic adenoma; Real time RT-PCR; Salivary gland tumors; TGFβ signaling pathway
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (Transforming Growth Factor beta)
تواريخ الأحداث: Date Created: 20240313 Date Completed: 20240417 Latest Revision: 20240426
رمز التحديث: 20240426
DOI: 10.1016/j.archoralbio.2024.105943
PMID: 38479278
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1506
DOI:10.1016/j.archoralbio.2024.105943