دورية أكاديمية
Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer.
| العنوان: | Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer. |
|---|---|
| المؤلفون: | Shouse AN; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., LaPorte KM; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Malek TR; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address: tmalek@med.miami.edu. |
| المصدر: | Immunity [Immunity] 2024 Mar 12; Vol. 57 (3), pp. 414-428. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: Cambridge, Mass. : Cell Press, c1994- |
| مواضيع طبية MeSH: | Interleukin-2*/metabolism , Neoplasms*, Humans ; Autoimmunity ; Receptors, Interleukin-2 ; T-Lymphocyte Subsets |
| مستخلص: | Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) supports the development and homeostasis of regulatory T cells and contributes to the differentiation of helper, cytotoxic, and memory T cells. A critical element for each T cell population is the expression of CD25 (Il2rα), which heightens the receptor affinity for IL-2. Signaling through the high-affinity IL-2R also reinvigorates CD8 + exhausted T (Tex) cells in response to checkpoint blockade. We consider the molecular underpinnings reflecting how IL-2R signaling impacts these various T cell subsets and the implications for enhancing IL-2-dependent immunotherapy of autoimmunity, other inflammatory disorders, and cancer. Competing Interests: Declaration of interests The University of Miami and Thomas Malek have a patent pending on IL-2/CD25 fusion proteins, and this technology has been licensed to Bristol Myers Squibb by the University of Miami for commercial development. Both receive royalties for its commercialization. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | F30 AI157211 United States AI NIAID NIH HHS; R01 AI131648 United States AI NIAID NIH HHS; R01 AI148675 United States AI NIAID NIH HHS; T32 AI162624 United States AI NIAID NIH HHS; R21 AI159489 United States AI NIAID NIH HHS; F31 AI124629 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: T cell exhaustion; autoimmunity; cancer immunotherapy; cytokine; cytokine signaling; effector T cells; immunotherapy; interleukin-2; interleukin-2 receptor; memory T cells; regulatory T cells |
| المشرفين على المادة: | 0 (Interleukin-2) 0 (Receptors, Interleukin-2) |
| تواريخ الأحداث: | Date Created: 20240313 Date Completed: 20240315 Latest Revision: 20240526 |
| رمز التحديث: | 20240526 |
| مُعرف محوري في PubMed: | PMC11126276 |
| DOI: | 10.1016/j.immuni.2024.02.001 |
| PMID: | 38479359 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4180 |
|---|---|
| DOI: | 10.1016/j.immuni.2024.02.001 |