دورية أكاديمية
Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer.
العنوان: | Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer. |
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المؤلفون: | Shouse AN; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., LaPorte KM; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Malek TR; Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address: tmalek@med.miami.edu. |
المصدر: | Immunity [Immunity] 2024 Mar 12; Vol. 57 (3), pp. 414-428. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: Cambridge, Mass. : Cell Press, c1994- |
مواضيع طبية MeSH: | Interleukin-2*/metabolism , Neoplasms*, Humans ; Autoimmunity ; Receptors, Interleukin-2 ; T-Lymphocyte Subsets |
مستخلص: | Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) supports the development and homeostasis of regulatory T cells and contributes to the differentiation of helper, cytotoxic, and memory T cells. A critical element for each T cell population is the expression of CD25 (Il2rα), which heightens the receptor affinity for IL-2. Signaling through the high-affinity IL-2R also reinvigorates CD8 + exhausted T (Tex) cells in response to checkpoint blockade. We consider the molecular underpinnings reflecting how IL-2R signaling impacts these various T cell subsets and the implications for enhancing IL-2-dependent immunotherapy of autoimmunity, other inflammatory disorders, and cancer. Competing Interests: Declaration of interests The University of Miami and Thomas Malek have a patent pending on IL-2/CD25 fusion proteins, and this technology has been licensed to Bristol Myers Squibb by the University of Miami for commercial development. Both receive royalties for its commercialization. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
References: | Nat Immunol. 2011 Mar;12(3):247-54. (PMID: 21278738) Nat Immunol. 2015 Jun;16(6):635-41. (PMID: 25939026) JAMA. 1994 Mar 23-30;271(12):907-13. (PMID: 8120958) Immunity. 2008 Apr;28(4):546-58. (PMID: 18387831) Cancer Immunol Immunother. 2021 Apr;70(4):909-921. (PMID: 33037893) Cell. 2006 Jul 28;126(2):375-87. (PMID: 16873067) J Immunother Cancer. 2021 Sep;9(9):. (PMID: 34475132) Science. 2003 Nov 7;302(5647):1041-3. (PMID: 14605368) J Exp Med. 1990 May 1;171(5):1509-26. (PMID: 1692080) Science. 1989 Nov 24;246(4933):1038-41. (PMID: 2511629) Nat Immunol. 2009 Jan;10(1):29-37. (PMID: 19043418) J Immunol. 2012 May 1;188(9):4644-53. (PMID: 22461703) Immunity. 2016 Sep 20;45(3):685-700. (PMID: 27566939) Cell. 2014 Aug 14;158(4):749-763. (PMID: 25126783) Nat Commun. 2014 Mar 17;5:3495. (PMID: 24633065) Nat Immunol. 2009 Sep;10(9):1000-7. (PMID: 19633673) Nat Immunol. 2011 Jul 31;12(9):908-13. (PMID: 21804558) Cancer Res. 2020 Nov 15;80(22):5063-5075. (PMID: 32948605) Nat Rev Immunol. 2012 Feb 10;12(3):157-67. (PMID: 22322317) Ann Rheum Dis. 2022 Dec;81(12):1685-1694. (PMID: 35973803) J Clin Oncol. 2023 Oct 20;41(30):4756-4767. (PMID: 37651676) Nature. 2007 Feb 22;445(7130):936-40. (PMID: 17237761) Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12111-12119. (PMID: 29078395) J Clin Invest. 2022 Feb 1;132(3):. (PMID: 35104810) J Immunol. 2012 Feb 1;188(3):1064-74. (PMID: 22227569) Annu Rev Immunol. 2008;26:453-79. (PMID: 18062768) Annu Rev Immunol. 2019 Apr 26;37:457-495. (PMID: 30676822) Nature. 2022 Oct;610(7930):173-181. (PMID: 36171288) Immunity. 2003 Nov;19(5):739-48. (PMID: 14614860) Nat Immunol. 2011 Sep 11;12(11):1055-62. (PMID: 21909091) Ann Rheum Dis. 2019 Feb;78(2):209-217. (PMID: 30472651) J Immunol. 2020 Nov 15;205(10):2667-2678. (PMID: 33055282) Front Immunol. 2016 Dec 07;7:531. (PMID: 28003809) J Exp Med. 2014 Jan 13;211(1):121-36. (PMID: 24378538) Immunity. 2018 Nov 20;49(5):899-914.e6. (PMID: 30413360) Nature. 2011 Sep 21;478(7368):250-4. (PMID: 21937990) Immunity. 2010 Aug 27;33(2):153-65. (PMID: 20732639) J Exp Med. 2006 Jul 10;203(7):1693-700. (PMID: 16818676) Mol Syst Biol. 2010 Nov 30;6:437. (PMID: 21119631) Nat Immunol. 2011 Nov 06;12(12):1221-9. (PMID: 22057289) Cells. 2023 Oct 31;12(21):. (PMID: 37947634) Cell Death Differ. 2017 Jun;24(6):1007-1016. (PMID: 28362433) PLoS One. 2008 Feb 13;3(2):e1581. (PMID: 18324310) J Exp Med. 1998 Dec 7;188(11):2067-74. (PMID: 9841920) Immunity. 2015 Oct 20;43(4):690-702. (PMID: 26410627) Immunity. 2021 May 11;54(5):947-961.e8. (PMID: 33930308) N Engl J Med. 2011 Dec 1;365(22):2067-77. (PMID: 22129253) Immunity. 2021 May 11;54(5):931-946.e11. (PMID: 33838102) J Exp Med. 2022 Jul 4;219(7):. (PMID: 35699942) J Clin Oncol. 1995 Mar;13(3):688-96. (PMID: 7884429) Immunity. 2023 Feb 14;56(2):240-255. (PMID: 36792571) Nat Immunol. 2005 Nov;6(11):1152-9. (PMID: 16227983) Cell Immunol. 2021 Jan;359:104251. (PMID: 33248367) Immunity. 2010 Jun 25;32(6):743-53. (PMID: 20620941) Sci Immunol. 2022 Feb 11;7(68):eabl6322. (PMID: 35148200) Front Immunol. 2022 Sep 08;13:965303. (PMID: 36159793) J Immunol. 2007 Jan 1;178(1):242-52. (PMID: 17182561) Immunity. 2019 Jan 15;50(1):195-211.e10. (PMID: 30635237) Nat Immunol. 2011 Nov;12(11):1045-54. (PMID: 21946417) Nat Commun. 2014 Nov 05;5:5377. (PMID: 25369785) iScience. 2020 Aug 21;23(8):101421. (PMID: 32791329) Cell. 2021 Jul 22;184(15):3981-3997.e22. (PMID: 34157301) Nature. 2010 Feb 11;463(7282):808-12. (PMID: 20072126) Eur J Immunol. 2008 Jul;38(7):1814-21. (PMID: 18546144) Science. 1995 Jun 9;268(5216):1472-6. (PMID: 7770771) Nature. 2021 Sep;597(7877):544-548. (PMID: 34526724) Science. 2009 Aug 21;325(5943):1006-10. (PMID: 19608860) J Immunol. 2007 Jan 1;178(1):280-90. (PMID: 17182565) Immunity. 2002 Aug;17(2):167-78. (PMID: 12196288) J Immunol. 2011 Jun 1;186(11):6329-37. (PMID: 21525380) J Immunol. 2013 May 1;190(9):4483-7. (PMID: 23543753) Immunol Rev. 2014 May;259(1):88-102. (PMID: 24712461) Mol Ther. 2014 Jul;22(7):1388-1395. (PMID: 24686272) Diabetes. 2015 Jun;64(6):2172-83. (PMID: 25576057) Nat Med. 2011 May;17(5):604-9. (PMID: 21532597) Immunity. 1995 Oct;3(4):521-30. (PMID: 7584142) J Immunol. 2007 Jun 1;178(11):6725-9. (PMID: 17513718) J Exp Med. 2005 Mar 7;201(5):723-35. (PMID: 15753206) J Immunol. 2020 Oct 1;205(7):1721-1730. (PMID: 32958706) J Immunol. 2020 Jun 15;204(12):3307-3314. (PMID: 32376651) JCI Insight. 2019 Mar 26;5:. (PMID: 30912768) J Exp Med. 2021 Dec 6;218(12):. (PMID: 34665220) J Transl Autoimmun. 2021 May 06;4:100103. (PMID: 34041473) Science. 2018 Sep 14;361(6407):. (PMID: 30213884) J Immunol. 2012 Aug 15;189(4):1780-91. (PMID: 22786769) Immunity. 2016 Aug 16;45(2):415-27. (PMID: 27533016) J Immunol. 2018 Jun 15;200(12):3926-3933. (PMID: 29728511) Cell Mol Immunol. 2019 Jul;16(7):634-643. (PMID: 30867582) J Immunother Cancer. 2023 Jun;11(6):. (PMID: 37270181) Immunity. 2012 Apr 20;36(4):586-99. (PMID: 22520852) Ann Rheum Dis. 2020 Jan;79(1):141-149. (PMID: 31537547) Nat Commun. 2019 Mar 4;10(1):1037. (PMID: 30833563) Annu Rev Med. 2021 Jan 27;72:281-311. (PMID: 33158368) J Exp Med. 2007 Mar 19;204(3):547-57. (PMID: 17312008) Sci Immunol. 2022 Nov 25;7(77):eabl9467. (PMID: 36427325) Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16601-6. (PMID: 20823247) Immunity. 2009 Feb 20;30(2):204-17. (PMID: 19185518) Nature. 2012 Mar 25;484(7395):529-33. (PMID: 22446627) Nat Immunol. 2014 Oct;15(10):957-64. (PMID: 25194422) Mucosal Immunol. 2021 Sep;14(5):1172-1182. (PMID: 34226674) Nat Immunol. 2007 Mar;8(3):277-84. (PMID: 17220892) Cell Rep. 2018 Oct 30;25(5):1204-1213.e4. (PMID: 30380412) Nature. 2007 Apr 5;446(7136):685-9. (PMID: 17377532) J Biol Chem. 2012 Mar 30;287(14):11234-9. (PMID: 22318729) Annu Rev Immunol. 2018 Apr 26;36:411-433. (PMID: 29677473) Nat Immunol. 2023 Apr;24(4):637-651. (PMID: 36959291) Nat Commun. 2020 Dec 22;11(1):6440. (PMID: 33353953) Nat Cancer. 2023 Sep;4(9):1309-1325. (PMID: 37550516) EBioMedicine. 2023 Apr;90:104539. (PMID: 37004361) Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5444-53. (PMID: 27573835) J Exp Med. 1990 Mar 1;171(3):935-40. (PMID: 2307937) Front Immunol. 2017 Feb 23;8:194. (PMID: 28280496) J Immunol. 2019 Jul 1;203(1):93-104. (PMID: 31085588) Cell Rep. 2021 May 11;35(6):109096. (PMID: 33979619) Nat Immunol. 2014 Nov;15(11):1070-8. (PMID: 25263123) Sci Immunol. 2018 Sep 14;3(27):. (PMID: 30217811) Immunity. 2010 Jan 29;32(1):79-90. (PMID: 20096607) Annu Rev Immunol. 2012;30:95-114. (PMID: 22149933) Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):193-8. (PMID: 19966302) Eur J Immunol. 2007 Jun;37(6):1502-12. (PMID: 17492805) Nat Rev Immunol. 2022 Oct;22(10):614-628. (PMID: 35217787) Front Immunol. 2022 May 04;13:886736. (PMID: 35603161) Curr Opin Immunol. 2008 Jun;20(3):259-64. (PMID: 18554885) Sci Transl Med. 2013 Apr 3;5(179):179ra43. (PMID: 23552371) Nature. 2017 Sep 7;549(7670):111-115. (PMID: 28854172) Immunity. 2013 Jun 27;38(6):1116-28. (PMID: 23746651) Nat Immunol. 2011 Jun;12(6):551-9. (PMID: 21516110) J Immunol. 2000 Mar 15;164(6):2905-14. (PMID: 10706676) Immunity. 2011 Jul 22;35(1):109-22. (PMID: 21723159) Science. 2005 Nov 18;310(5751):1159-63. (PMID: 16293754) Cell. 1997 May 16;89(4):587-96. (PMID: 9160750) Nat Immunol. 2019 Feb;20(2):195-205. (PMID: 30643267) Cell. 2013 Jun 6;153(6):1239-51. (PMID: 23746840) Nat Immunol. 2008 Nov;9(11):1288-96. (PMID: 18820682) Immunity. 2006 Aug;25(2):249-59. (PMID: 16879995) Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1000-5. (PMID: 16418296) Immunity. 2023 Jan 10;56(1):162-179.e6. (PMID: 36630914) J Exp Med. 2019 Nov 4;216(11):2466-2478. (PMID: 31434685) Nat Immunol. 2017 Nov;18(11):1249-1260. (PMID: 28892471) Nat Rev Immunol. 2004 Nov;4(11):900-11. (PMID: 15516969) J Immunol. 2014 Dec 1;193(11):5525-33. (PMID: 25348623) Elife. 2016 Mar 21;5:. (PMID: 26999798) Immunity. 2020 May 19;52(5):825-841.e8. (PMID: 32396847) J Immunol. 2001 Feb 1;166(3):1675-83. (PMID: 11160210) Nature. 2015 Feb 19;518(7539):337-43. (PMID: 25363779) Nature. 2022 Oct;610(7930):161-172. (PMID: 36171284) Nature. 2016 Sep 15;537(7620):417-421. (PMID: 27501248) Cell Rep. 2022 Apr 12;39(2):110632. (PMID: 35417685) Immunity. 2007 Mar;26(3):371-81. (PMID: 17363300) J Exp Med. 2012 Feb 13;209(2):243-50. (PMID: 22271576) Nat Immunol. 2018 Mar;19(3):291-301. (PMID: 29434354) Nat Immunol. 2021 Mar;22(3):358-369. (PMID: 33432230) J Immunol. 2003 Dec 1;171(11):5853-64. (PMID: 14634095) Nat Immunol. 2011 Oct 30;12(12):1212-20. (PMID: 22037603) Nat Rev Immunol. 2019 Nov;19(11):665-674. (PMID: 31570879) Cell. 2012 Jul 6;150(1):29-38. (PMID: 22770213) Diabetes. 2020 Nov;69(11):2400-2413. (PMID: 32843568) Immunity. 2012 May 25;36(5):847-56. (PMID: 22464171) J Exp Med. 2017 Nov 6;214(11):3381-3398. (PMID: 29018045) J Exp Med. 2003 Dec 15;198(12):1875-86. (PMID: 14676299) Science. 2012 Nov 30;338(6111):1220-5. (PMID: 23197535) J Immunol. 1995 Aug 1;155(3):1151-64. (PMID: 7636184) Cell Mol Immunol. 2021 Feb;18(2):398-414. (PMID: 33408345) N Engl J Med. 2011 Dec 1;365(22):2055-66. (PMID: 22129252) Immunity. 2019 May 21;50(5):1132-1148. (PMID: 31117010) Nat Immunol. 2022 Nov;23(11):1588-1599. (PMID: 36266363) Sci Immunol. 2019 Sep 13;4(39):. (PMID: 31519812) Immunity. 2010 Jan 29;32(1):91-103. (PMID: 20096608) Immunity. 2023 Dec 12;56(12):2699-2718.e11. (PMID: 38091951) J Crohns Colitis. 2021 Dec 18;15(12):2054-2065. (PMID: 34120187) Cell. 2000 Mar 17;100(6):655-69. (PMID: 10761931) Am J Pathol. 2012 Jul;181(1):8-18. (PMID: 22640807) Nat Immunol. 2016 Nov;17(11):1322-1333. (PMID: 27595233) J Immunol. 2018 Nov 1;201(9):2579-2592. (PMID: 30282751) J Invest Dermatol. 2021 Apr;141(4):933-936.e6. (PMID: 32941917) Blood. 2006 Mar 15;107(6):2409-14. (PMID: 16304057) Nat Immunol. 2022 May;23(5):802-813. (PMID: 35449416) J Exp Med. 2006 Jul 10;203(7):1701-11. (PMID: 16818678) J Clin Invest. 2006 Sep;116(9):2521-31. (PMID: 16917540) Nat Immunol. 2005 Nov;6(11):1142-51. (PMID: 16227984) Blood. 2007 May 15;109(10):4368-75. (PMID: 17227828) Nature. 2019 Apr;568(7752):405-409. (PMID: 30944470) Cell. 1993 Oct 22;75(2):253-61. (PMID: 8402910) J Immunol. 2008 Jul 1;181(1):225-34. (PMID: 18566388) J Immunol. 2008 Sep 1;181(5):3285-90. (PMID: 18714000) Arthritis Res Ther. 2021 Jun 11;23(1):167. (PMID: 34116715) Immunity. 2001 Jul;15(1):159-72. (PMID: 11485747) Immunity. 2013 Jan 24;38(1):13-25. (PMID: 23352221) J Immunol. 2007 Oct 1;179(7):4685-93. (PMID: 17878367) Nat Commun. 2022 Apr 26;13(1):2240. (PMID: 35474218) Eur J Immunol. 1995 Nov;25(11):3053-9. (PMID: 7489743) Nat Rev Immunol. 2018 Oct;18(10):648-659. (PMID: 30089912) Science. 2015 Aug 28;349(6251):993-7. (PMID: 26272906) Clin Exp Immunol. 2020 Jun;200(3):228-241. (PMID: 31989589) Cell Cycle. 2014;13(4):501-2. (PMID: 24419076) Sci Immunol. 2016 Dec 23;1(6):. (PMID: 28018990) EMBO J. 2023 Apr 17;42(8):e109803. (PMID: 36917143) J Immunol. 2016 May 1;196(9):3665-76. (PMID: 27009492) Immunity. 2000 Jan;12(1):27-37. (PMID: 10661403) Int Immunol. 2008 Aug;20(8):1041-55. (PMID: 18567616) Cell Immunol. 2009;257(1-2):69-79. (PMID: 19338979) Nat Med. 2016 Sep;22(9):991-3. (PMID: 27500725) J Autoimmun. 2019 Nov;104:102310. (PMID: 31421963) Blood. 2014 Dec 4;124(24):3572-6. (PMID: 25323825) |
معلومات مُعتمدة: | F30 AI157211 United States AI NIAID NIH HHS; R01 AI131648 United States AI NIAID NIH HHS; R01 AI148675 United States AI NIAID NIH HHS; T32 AI162624 United States AI NIAID NIH HHS; R21 AI159489 United States AI NIAID NIH HHS; F31 AI124629 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: T cell exhaustion; autoimmunity; cancer immunotherapy; cytokine; cytokine signaling; effector T cells; immunotherapy; interleukin-2; interleukin-2 receptor; memory T cells; regulatory T cells |
المشرفين على المادة: | 0 (Interleukin-2) 0 (Receptors, Interleukin-2) |
تواريخ الأحداث: | Date Created: 20240313 Date Completed: 20240315 Latest Revision: 20240526 |
رمز التحديث: | 20240526 |
مُعرف محوري في PubMed: | PMC11126276 |
DOI: | 10.1016/j.immuni.2024.02.001 |
PMID: | 38479359 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1097-4180 |
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DOI: | 10.1016/j.immuni.2024.02.001 |