دورية أكاديمية
أعرض في EDS

Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.

التفاصيل البيبلوغرافية
العنوان: Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.
المؤلفون: Mateus JC; i3S- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal., Sousa MM; i3S- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal., Burrone J; MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom.; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom., Aguiar P; i3S- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal pauloaguiar@i3s.up.pt.
المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Mar 13; Vol. 44 (11). Date of Electronic Publication: 2024 Mar 13.
نوع المنشور: Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington, DC : Society for Neuroscience
Original Publication: [Baltimore, Md.] : The Society, c1981-
مواضيع طبية MeSH: Axons*/physiology , Neurons*, Action Potentials/physiology ; Electrophysiological Phenomena ; Electrophysiology
مستخلص: The axon is a neuronal structure capable of processing, encoding, and transmitting information. This assessment contrasts with a limiting, but deeply rooted, perspective where the axon functions solely as a transmission cable of somatodendritic activity, sending signals in the form of stereotypical action potentials. This perspective arose, at least partially, because of the technical difficulties in probing axons: their extreme length-to-diameter ratio and intricate growth paths preclude the study of their dynamics through traditional techniques. Recent findings are challenging this view and revealing a much larger repertoire of axonal computations. Axons display complex signaling processes and structure-function relationships, which can be modulated via diverse activity-dependent mechanisms. Additionally, axons can exhibit patterns of activity that are dramatically different from those of their corresponding soma. Not surprisingly, many of these recent discoveries have been driven by novel technology developments, which allow for in vitro axon electrophysiology with unprecedented spatiotemporal resolution and signal-to-noise ratio. In this review, we outline the state-of-the-art in vitro toolset for axonal electrophysiology and summarize the recent discoveries in axon function it has enabled. We also review the increasing repertoire of microtechnologies for controlling axon guidance which, in combination with the available cutting-edge electrophysiology and imaging approaches, have the potential for more controlled and high-throughput in vitro studies. We anticipate that a larger adoption of these new technologies by the neuroscience community will drive a new era of experimental opportunities in the study of axon physiology and consequently, neuronal function.
Competing Interests: The authors declare no competing financial interests.
(Copyright © 2024 the authors.)
References: J Neurosci Methods. 2021 Aug 1;360:109251. (PMID: 34119572)
Biophys J. 2009 May 20;96(10):3959-76. (PMID: 19450468)
Lab Chip. 2019 Apr 9;19(8):1484-1489. (PMID: 30899932)
Nano Lett. 2017 May 10;17(5):2757-2764. (PMID: 28384403)
Lab Chip. 2013 Feb 21;13(4):498-508. (PMID: 23288417)
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2395-2400. (PMID: 28193892)
IEEE Trans Biomed Eng. 2021 Dec;68(12):3574-3581. (PMID: 33970856)
Front Synaptic Neurosci. 2019 Apr 16;11:12. (PMID: 31057389)
J Neurosci. 2012 Jan 11;32(2):626-38. (PMID: 22238098)
Nat Neurosci. 2020 Nov;23(11):1399-1409. (PMID: 32895566)
Sci Adv. 2018 Nov 28;4(11):eaau8621. (PMID: 30498783)
Nature. 2010 Jun 24;465(7301):1070-4. (PMID: 20543823)
Sci Adv. 2020 May 06;6(19):eaay4313. (PMID: 32494697)
Nat Commun. 2020 Dec 9;11(1):6313. (PMID: 33298939)
Front Cell Neurosci. 2017 Feb 27;11:45. (PMID: 28289377)
Lab Chip. 2016 Apr 26;16(9):1684-90. (PMID: 27053163)
Nat Rev Neurosci. 2019 Dec;20(12):719-727. (PMID: 31705060)
Neuron. 2012 Jan 26;73(2):235-47. (PMID: 22284179)
Front Cell Neurosci. 2019 Mar 01;13:52. (PMID: 30881287)
Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):E607-16. (PMID: 21768381)
J Neurosci. 1988 Nov;8(11):4098-120. (PMID: 3054009)
Neuron. 2022 Sep 21;110(18):2949-2960.e4. (PMID: 35931070)
Nat Neurosci. 2009 Aug;12(8):996-1002. (PMID: 19633666)
Cell. 2019 May 16;177(5):1346-1360.e24. (PMID: 31080068)
Elife. 2021 Mar 08;10:. (PMID: 33683198)
Nat Neurosci. 2022 Aug;25(8):984-998. (PMID: 35835882)
Science. 2011 Feb 4;331(6017):599-601. (PMID: 21292979)
Biomaterials. 2005 May;26(15):2549-57. (PMID: 15585257)
PLoS One. 2010 Oct 29;5(10):e13761. (PMID: 21048938)
Nat Rev Neurosci. 2013 Jan;14(1):63-9. (PMID: 23187813)
J Neurosci. 2012 Feb 22;32(8):2868-76. (PMID: 22357869)
Adv Biosyst. 2019 Feb;3(2):e1800308. (PMID: 30882024)
RSC Adv. 2019 Dec 24;10(1):187-200. (PMID: 35492533)
Cell Rep. 2017 Feb 21;18(8):2018-2029. (PMID: 28228266)
Elife. 2018 Aug 09;7:. (PMID: 30091701)
Small. 2018 Jul 20;:e1801763. (PMID: 30028572)
Nano Lett. 2014 Dec 10;14(12):6906-9. (PMID: 25415470)
Neuron. 2011 Jan 13;69(1):9-21. (PMID: 21220095)
Neuron Glia Biol. 2007 Nov;3(4):325-34. (PMID: 18634564)
Front Synaptic Neurosci. 2016 Jul 26;8:21. (PMID: 27507942)
Adv Mater. 2020 Jun;32(25):e1908299. (PMID: 32390195)
Appl Microsc. 2021 Mar 17;51(1):2. (PMID: 33730244)
J Neural Eng. 2021 Dec 29;18(6):. (PMID: 34891149)
Neuron. 2020 Aug 5;107(3):509-521.e7. (PMID: 32492366)
Science. 1979 Nov 30;206(4422):1079-80. (PMID: 493992)
Science. 2022 Sep 23;377(6613):1448-1452. (PMID: 36137045)
Sci Adv. 2019 Oct 23;5(10):eaax4755. (PMID: 31681845)
Exp Neurol. 1959 Nov;1:491-527. (PMID: 14435979)
Lab Chip. 2014 Feb 21;14(4):799-805. (PMID: 24366209)
Nat Neurosci. 2010 Apr;13(4):431-8. (PMID: 20305647)
ACS Appl Mater Interfaces. 2018 May 2;10(17):15207-15215. (PMID: 29620843)
Elife. 2020 Jun 17;9:. (PMID: 32553116)
Curr Opin Neurobiol. 2018 Aug;51:37-44. (PMID: 29525575)
Brain. 2022 Jun 3;145(5):1632-1640. (PMID: 35661858)
eNeuro. 2021 Aug 3;8(4):. (PMID: 34257077)
J Vis Exp. 2018 Dec 8;(142):. (PMID: 30582587)
Langmuir. 2003 Mar 4;19(5):1551-1556. (PMID: 20725530)
PLoS One. 2018 Apr 25;13(4):e0194031. (PMID: 29694385)
Cell Rep. 2021 Jan 12;34(2):108612. (PMID: 33440142)
Elife. 2017 Oct 09;6:. (PMID: 28990925)
Front Cell Neurosci. 2019 Sep 18;13:413. (PMID: 31619963)
Curr Opin Neurobiol. 2018 Aug;51:52-59. (PMID: 29533849)
PLoS One. 2015 Mar 03;10(3):e0118514. (PMID: 25734567)
Lab Chip. 2015 Dec 21;15(24):4578-90. (PMID: 26507288)
Lab Chip. 2022 Mar 29;22(7):1386-1403. (PMID: 35253810)
Nat Biomed Eng. 2020 Feb;4(2):232-241. (PMID: 31548592)
Nat Rev Neurosci. 2019 May;20(5):253-271. (PMID: 30824857)
Prog Neurobiol. 2011 Sep 1;94(4):307-46. (PMID: 21708220)
Adv Mater. 2021 Nov;33(47):e2005805. (PMID: 34013548)
J Neural Eng. 2019 Jun;16(3):036012. (PMID: 30818300)
Nat Nanotechnol. 2019 Jul;14(7):645-657. (PMID: 31270446)
Nat Commun. 2021 Jul 5;12(1):4129. (PMID: 34226561)
J Neural Eng. 2020 Aug 04;17(4):046019. (PMID: 32650319)
J Physiol. 2021 Jan;599(1):49-66. (PMID: 33094478)
Neuron. 2018 Apr 4;98(1):156-165.e6. (PMID: 29621485)
Sci Rep. 2017 Nov 15;7(1):15625. (PMID: 29142321)
Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10234-E10243. (PMID: 29109270)
Lab Chip. 2022 Nov 22;22(23):4541-4555. (PMID: 36318066)
Biomaterials. 2014 Sep;35(27):7750-61. (PMID: 24954734)
Dev Dyn. 2019 Jan;248(1):65-77. (PMID: 30117633)
Sci Rep. 2016 Jun 03;6:27110. (PMID: 27256971)
Lab Chip. 2018 Nov 6;18(22):3425-3435. (PMID: 30289147)
Front Neurosci. 2022 Apr 18;16:854637. (PMID: 35509449)
Nature. 2006 Jun 8;441(7094):761-5. (PMID: 16625207)
Nature. 2023 Mar;615(7954):884-891. (PMID: 36922596)
Biosens Bioelectron. 2018 Dec 30;122:75-87. (PMID: 30243047)
Nat Neurosci. 2014 May;17(5):686-93. (PMID: 24657965)
Nat Neurosci. 2011 Feb;14(2):139-42. (PMID: 21270781)
J Neurosci. 2017 Sep 27;37(39):9519-9533. (PMID: 28871036)
Science. 2010 May 14;328(5980):906-9. (PMID: 20466935)
ACS Nano. 2022 Apr 26;16(4):5731-5742. (PMID: 35404570)
Brain. 2020 Dec 5;143(11):3181-3213. (PMID: 33020798)
J Neurochem. 2021 Feb;156(3):324-336. (PMID: 33037623)
Nat Nanotechnol. 2012 Jan 10;7(3):180-4. (PMID: 22231664)
Nat Neurosci. 2010 Jul;13(7):852-60. (PMID: 20543843)
Nat Neurosci. 2011 Feb;14(2):200-7. (PMID: 21150916)
Nat Protoc. 2021 Jun;16(6):2947-2967. (PMID: 33990799)
Curr Opin Neurobiol. 2019 Aug;57:117-125. (PMID: 30784979)
PLoS One. 2015 Nov 04;10(11):e0142052. (PMID: 26536117)
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1401-1406. (PMID: 28115721)
Nat Protoc. 2006;1(4):2128-36. (PMID: 17487204)
Physiol Rev. 2011 Apr;91(2):555-602. (PMID: 21527732)
Nano Lett. 2017 Jun 14;17(6):3932-3939. (PMID: 28534411)
Nature. 2009 Oct 15;461(7266):930-9. (PMID: 19829373)
Biosens Bioelectron. 2021 Mar 1;175:112854. (PMID: 33371989)
J Neurosci Res. 2012 Jul;90(7):1335-46. (PMID: 22431311)
IEEE Trans Biomed Eng. 2017 Feb;64(2):492-498. (PMID: 27187941)
Front Cell Neurosci. 2019 Apr 24;13:160. (PMID: 31105529)
Front Bioeng Biotechnol. 2020 Oct 22;8:551505. (PMID: 33195116)
Neuron. 2016 Jul 20;91(2):370-83. (PMID: 27346528)
Adv Sci (Weinh). 2021 May 11;8(13):2004434. (PMID: 36246164)
Neuron. 2018 Sep 5;99(5):969-984.e7. (PMID: 30122380)
Nat Methods. 2010 Mar;7(3):200-2. (PMID: 20118930)
Brain. 2021 Jul 28;144(6):1727-1737. (PMID: 33734317)
Elife. 2023 Aug 22;12:. (PMID: 37606618)
J Physiol. 2023 May;601(10):1957-1979. (PMID: 36946031)
ACS Chem Neurosci. 2016 Oct 19;7(10):1325-1330. (PMID: 27529437)
Nature. 1996 May 23;381(6580):322-5. (PMID: 8692270)
Nat Nanotechnol. 2013 Feb;8(2):83-94. (PMID: 23380931)
Sci Adv. 2023 Oct 13;9(41):eade4511. (PMID: 37824608)
J Neural Eng. 2012 Apr;9(2):026010. (PMID: 22333069)
Nat Neurosci. 2022 Oct;25(10):1288-1299. (PMID: 36163283)
J Neurophysiol. 2018 Jul 1;120(1):306-320. (PMID: 29641308)
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4516-9. (PMID: 270699)
Front Mol Neurosci. 2014 Dec 05;7:97. (PMID: 25538558)
Sci Rep. 2019 Apr 8;9(1):5777. (PMID: 30962522)
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4051-6. (PMID: 23341597)
Nat Commun. 2018 Oct 18;9(1):4336. (PMID: 30337521)
Sci Rep. 2017 Apr 20;7(1):978. (PMID: 28428560)
Nat Commun. 2016 Jul 06;7:12102. (PMID: 27381274)
Neuron. 2015 Mar 18;85(6):1273-88. (PMID: 25728570)
Commun Biol. 2021 Apr 12;4(1):461. (PMID: 33846537)
Science. 2006 Mar 3;311(5765):1290-3. (PMID: 16513983)
Nat Neurosci. 2008 Feb;11(2):178-86. (PMID: 18204443)
PLoS One. 2012;7(3):e33623. (PMID: 22457779)
Nat Rev Neurosci. 2020 Apr;21(4):213-229. (PMID: 32161339)
Neuron. 2005 Feb 3;45(3):405-17. (PMID: 15694327)
J Neurosci. 2021 Jun 4;:. (PMID: 34099506)
J Physiol. 2000 Dec 15;529 Pt 3:625-46. (PMID: 11118494)
J Physiol. 2017 Dec 15;595(24):7477-7493. (PMID: 29072780)
Sci Rep. 2017 Aug 17;7(1):8558. (PMID: 28819130)
Nat Methods. 2007 Aug;4(8):619-28. (PMID: 17664946)
Cell Rep. 2019 Jan 15;26(3):802-813.e4. (PMID: 30650368)
Science. 2012 Jun 15;336(6087):1458-61. (PMID: 22700932)
Trends Neurosci. 2012 Dec;35(12):752-61. (PMID: 23031246)
Nat Methods. 2005 Aug;2(8):599-605. (PMID: 16094385)
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5057-62. (PMID: 21383151)
Front Mol Neurosci. 2018 Sep 04;11:319. (PMID: 30233318)
Ann Biomed Eng. 2012 Jun;40(6):1268-76. (PMID: 22302320)
Nat Protoc. 2006;1(4):2075-81. (PMID: 17487197)
Pflugers Arch. 1981 Aug;391(2):85-100. (PMID: 6270629)
J Neurosci. 2016 Nov 16;36(46):11573-11584. (PMID: 27852766)
Front Mol Neurosci. 2020 Oct 21;13:572312. (PMID: 33192296)
Nat Rev Neurosci. 2007 Jun;8(6):451-65. (PMID: 17514198)
Nat Commun. 2021 Feb 10;12(1):936. (PMID: 33568670)
Neurochem Res. 2003 Nov;28(11):1639-48. (PMID: 14584818)
Commun Biol. 2023 Mar 18;6(1):290. (PMID: 36934174)
J Neural Eng. 2022 Aug 23;19(4):. (PMID: 35931040)
J Neurosci Res. 2021 May;99(5):1276-1307. (PMID: 33583054)
J Neurophysiol. 2012 Aug 1;108(3):729-40. (PMID: 22572942)
Nat Protoc. 2012 May 31;7(6):1228-34. (PMID: 22653161)
Nat Methods. 2009 Dec;6(12):883-9. (PMID: 19898484)
J Neurosci. 1982 Apr;2(4):483-96. (PMID: 6279799)
Neuron. 2014 Nov 19;84(4):778-89. (PMID: 25447742)
Neuron. 2019 Mar 6;101(5):863-875.e6. (PMID: 30704911)
Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7184-E7192. (PMID: 29991598)
J Neurosci. 2021 Jun 23;41(25):5372-5385. (PMID: 34001627)
Sci Rep. 2015 Mar 02;5:8644. (PMID: 25728549)
J Neurosci Methods. 2019 Oct 1;326:108357. (PMID: 31336060)
Nat Commun. 2018 Oct 23;9(1):4403. (PMID: 30353009)
Front Neurosci. 2022 Feb 21;16:829884. (PMID: 35264928)
Front Neurosci. 2015 Jan 06;8:423. (PMID: 25610364)
Science. 2022 Mar 25;375(6587):1378-1385. (PMID: 35324301)
Acta Biomater. 2017 Mar 15;51:21-52. (PMID: 28069509)
Anal Chem. 1998 Dec 1;70(23):4974-84. (PMID: 21644679)
Lab Chip. 2009 Feb 7;9(3):404-10. (PMID: 19156289)
Nat Neurosci. 2018 Jun;21(6):787-793. (PMID: 29760524)
Elife. 2020 Mar 20;9:. (PMID: 32195665)
ACS Appl Mater Interfaces. 2021 May 26;13(20):23438-23451. (PMID: 33983012)
Nat Commun. 2018 Oct 8;9(1):4125. (PMID: 30297821)
PLoS One. 2017 May 11;12(5):e0176868. (PMID: 28493886)
Cell Rep Methods. 2023 Jan 12;3(1):100385. (PMID: 36814833)
J Neurosci Methods. 2001 Sep 30;110(1-2):17-24. (PMID: 11564520)
Neuron. 2013 Sep 18;79(6):1067-77. (PMID: 24050398)
Nano Lett. 2017 Jun 14;17(6):3369-3375. (PMID: 28437614)
Sci Adv. 2021 Jan 29;7(5):. (PMID: 33514550)
Adv Sci (Weinh). 2023 Jul;10(20):e2207732. (PMID: 37088859)
Nat Methods. 2019 Jul;16(7):649-657. (PMID: 31209382)
Nat Commun. 2013;4:2181. (PMID: 23867868)
PLoS One. 2013 Jun 13;8(6):e66170. (PMID: 23785482)
Langmuir. 2019 Feb 26;35(8):2966-2975. (PMID: 30767535)
J Neurosci. 1996 Nov 1;16(21):6676-86. (PMID: 8824308)
Elife. 2020 Sep 01;9:. (PMID: 32870779)
Neuron. 2012 Mar 8;73(5):862-85. (PMID: 22405199)
Nature. 2010 Jun 24;465(7301):1075-8. (PMID: 20543825)
Adv Healthc Mater. 2017 Aug;6(15):. (PMID: 28640544)
Front Cell Neurosci. 2019 Apr 26;13:159. (PMID: 31118887)
Lab Chip. 2020 Aug 26;20(17):3239-3248. (PMID: 32756639)
Nat Commun. 2020 Sep 25;11(1):4854. (PMID: 32978383)
IEEE Trans Neural Syst Rehabil Eng. 2014 May;22(3):453-9. (PMID: 24240004)
Sci Rep. 2012;2:675. (PMID: 22997549)
Trends Neurosci. 2018 Dec;41(12):880-884. (PMID: 30287084)
Small. 2016 Mar 2;12(9):1148-52. (PMID: 26395860)
Cell. 2020 Jan 23;180(2):311-322.e15. (PMID: 31883793)
Annu Rev Biophys Bioeng. 1980;9:143-79. (PMID: 6994588)
Nat Chem Biol. 2019 Feb;15(2):101-110. (PMID: 30659298)
J Physiol. 1952 Aug;117(4):500-44. (PMID: 12991237)
J Neurosci. 2013 Nov 6;33(45):17647-55. (PMID: 24198357)
Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29937-29947. (PMID: 33168717)
Nat Neurosci. 2011 Jan;14(1):62-8. (PMID: 21170054)
Nat Neurosci. 2018 Sep;21(9):1272-1280. (PMID: 30127424)
Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5174-E5182. (PMID: 29760100)
Lab Chip. 2011 Nov 7;11(21):3663-73. (PMID: 21922081)
Adv Healthc Mater. 2022 May;11(10):e2101817. (PMID: 35118820)
Nat Methods. 2014 Aug;11(8):825-33. (PMID: 24952910)
Mol Ther Methods Clin Dev. 2019 Nov 26;17:69-82. (PMID: 31890742)
eNeuro. 2017 Jul 25;4(4):. (PMID: 28785728)
Cell. 2022 Sep 1;185(18):3408-3425.e29. (PMID: 35985322)
Science. 2014 Feb 7;343(6171):665-70. (PMID: 24503854)
J Physiol. 2011 Sep 1;589(17):4167-87. (PMID: 21669974)
Nature. 2022 Oct;610(7931):319-326. (PMID: 36224417)
J Neurosci. 2021 Apr 28;41(17):3764-3776. (PMID: 33731449)
فهرسة مساهمة: Keywords: axon computations; axon electrophysiology; axon guidance; functional imaging; microelectrode arrays
تواريخ الأحداث: Date Created: 20240313 Date Completed: 20240315 Latest Revision: 20240325
رمز التحديث: 20240325
مُعرف محوري في PubMed: PMC10941245
DOI: 10.1523/JNEUROSCI.1446-23.2023
PMID: 38479812
قاعدة البيانات: MEDLINE
الوصف
تدمد:1529-2401
DOI:10.1523/JNEUROSCI.1446-23.2023