دورية أكاديمية
Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.
العنوان: | Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology. |
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المؤلفون: | Mateus JC; i3S- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal., Sousa MM; i3S- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal., Burrone J; MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom.; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom., Aguiar P; i3S- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal pauloaguiar@i3s.up.pt. |
المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Mar 13; Vol. 44 (11). Date of Electronic Publication: 2024 Mar 13. |
نوع المنشور: | Review; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
مواضيع طبية MeSH: | Axons*/physiology , Neurons*, Action Potentials/physiology ; Electrophysiological Phenomena ; Electrophysiology |
مستخلص: | The axon is a neuronal structure capable of processing, encoding, and transmitting information. This assessment contrasts with a limiting, but deeply rooted, perspective where the axon functions solely as a transmission cable of somatodendritic activity, sending signals in the form of stereotypical action potentials. This perspective arose, at least partially, because of the technical difficulties in probing axons: their extreme length-to-diameter ratio and intricate growth paths preclude the study of their dynamics through traditional techniques. Recent findings are challenging this view and revealing a much larger repertoire of axonal computations. Axons display complex signaling processes and structure-function relationships, which can be modulated via diverse activity-dependent mechanisms. Additionally, axons can exhibit patterns of activity that are dramatically different from those of their corresponding soma. Not surprisingly, many of these recent discoveries have been driven by novel technology developments, which allow for in vitro axon electrophysiology with unprecedented spatiotemporal resolution and signal-to-noise ratio. In this review, we outline the state-of-the-art in vitro toolset for axonal electrophysiology and summarize the recent discoveries in axon function it has enabled. We also review the increasing repertoire of microtechnologies for controlling axon guidance which, in combination with the available cutting-edge electrophysiology and imaging approaches, have the potential for more controlled and high-throughput in vitro studies. We anticipate that a larger adoption of these new technologies by the neuroscience community will drive a new era of experimental opportunities in the study of axon physiology and consequently, neuronal function. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 the authors.) |
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فهرسة مساهمة: | Keywords: axon computations; axon electrophysiology; axon guidance; functional imaging; microelectrode arrays |
تواريخ الأحداث: | Date Created: 20240313 Date Completed: 20240315 Latest Revision: 20240325 |
رمز التحديث: | 20240325 |
مُعرف محوري في PubMed: | PMC10941245 |
DOI: | 10.1523/JNEUROSCI.1446-23.2023 |
PMID: | 38479812 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1529-2401 |
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DOI: | 10.1523/JNEUROSCI.1446-23.2023 |