دورية أكاديمية
أعرض في EDS

FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma.

التفاصيل البيبلوغرافية
العنوان: FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma.
المؤلفون: Fujimori H; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan., Shima-Nakamura M; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan., Kanno SI; IDAC Fellow Research Group for DNA Repair and Dynamic Proteome Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan., Shibuya-Takahashi R; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan., Mochizuki M; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan., Mizuma M; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan., Unno M; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan., Wakui Y; Department of Gastroenterology, Miyagi Cancer Center, Natori, Japan., Abue M; Department of Gastroenterology, Miyagi Cancer Center, Natori, Japan., Iwai W; Department of Gastroenterology, Miyagi Cancer Center, Natori, Japan., Fukushi D; Division of Gastroenterology, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Satoh K; Division of Gastroenterology, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Yamaguchi K; Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan., Shindo N; Cancer Chromosome Biology Unit, Miyagi Cancer Center Research Institute, Natori, Japan., Yasuda J; Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan., Tamai K; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.
المصدر: Cancer science [Cancer Sci] 2024 Jun; Vol. 115 (6), pp. 1896-1909. Date of Electronic Publication: 2024 Mar 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Oxford : Wiley Publishing on behalf of the Japanese Cancer Association
Original Publication: Tokyo : Japanese Cancer Association, c2003-
مواضيع طبية MeSH: Annexin A2*/metabolism , Annexin A2*/genetics , Bile Duct Neoplasms*/metabolism , Bile Duct Neoplasms*/pathology , Bile Duct Neoplasms*/genetics , Carcinogenesis*/genetics , Carcinogenesis*/metabolism , Cholangiocarcinoma*/metabolism , Cholangiocarcinoma*/genetics , Cholangiocarcinoma*/pathology , Mitochondria*/metabolism , src-Family Kinases*/metabolism , src-Family Kinases*/genetics, Animals ; Humans ; Male ; Mice ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Mice, Nude ; Phosphorylation ; Signal Transduction
مستخلص: Cholangiocarcinoma (CCA) is one of the most difficult malignancies to treat as the therapeutic options are limited. Although several driver genes have been identified, most remain unknown. In this study, we identified a failed axon connection homolog (FAXC), whose function is unknown in mammals, by analyzing serially passaged CCA xenograft models. Knockdown of FAXC reduced subcutaneous tumorigenicity in mice. FAXC was bound to annexin A2 (ANXA2) and c-SRC, which are tumor-promoting genes. The FAXC/ANXA2/c-SRC complex forms in the mitochondria. FAXC enhances SRC-dependent ANXA2 phosphorylation at tyrosine-24, and the C-terminal amino acid residues (351-375) of FAXC are required for ANXA2 phosphorylation. Transcriptome data from a xenografted CCA cell line revealed that FAXC correlated with epithelial-mesenchymal transition, hypoxia, and KRAS signaling genes. Collectively, these findings advance our understanding of CCA tumorigenesis and provide candidate therapeutic targets.
(© 2024 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.)
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معلومات مُعتمدة: Kobayashi Foundation for Cancer Research; 19K08430 Japan Society for the Promotion of Science; 20K09701 Japan Society for the Promotion of Science; 21H02396 Japan Society for the Promotion of Science; 21K07137 Japan Society for the Promotion of Science; 21K07186 Japan Society for the Promotion of Science; 21K07973 Japan Society for the Promotion of Science; 22K07974 Japan Society for the Promotion of Science; 22K08085 Japan Society for the Promotion of Science; 22K09678 Japan Society for the Promotion of Science; 22K09696 Japan Society for the Promotion of Science; Takeda Medical Research Foundation
فهرسة مساهمة: Keywords: ANXA2; FAXC; SRC; cholangiocarcinoma; tumorigenicity
المشرفين على المادة: 0 (Annexin A2)
0 (ANXA2 protein, human)
EC 2.7.10.2 (src-Family Kinases)
تواريخ الأحداث: Date Created: 20240313 Date Completed: 20240603 Latest Revision: 20240708
رمز التحديث: 20240708
مُعرف محوري في PubMed: PMC11145136
DOI: 10.1111/cas.16140
PMID: 38480477
قاعدة البيانات: MEDLINE
الوصف
تدمد:1349-7006
DOI:10.1111/cas.16140