دورية أكاديمية
Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia.
| العنوان: | Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia. |
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| المؤلفون: | Rees TA; School of Biological Sciences, University of Auckland, Auckland, 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, 1010, New Zealand., Tasma Z; School of Biological Sciences, University of Auckland, Auckland, 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, 1010, New Zealand., Garelja ML; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, 1010, New Zealand.; Department of Pharmacology and Toxicology, University of Otago, Dunedin, 9016, New Zealand., O'Carroll SJ; Department of Anatomy and Medical Imaging, Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Auckland, 1023, New Zealand., Walker CS; School of Biological Sciences, University of Auckland, Auckland, 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, 1010, New Zealand., Hay DL; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, 1010, New Zealand. debbie.hay@otago.ac.nz.; Department of Pharmacology and Toxicology, University of Otago, Dunedin, 9016, New Zealand. debbie.hay@otago.ac.nz. |
| المصدر: | The journal of headache and pain [J Headache Pain] 2024 Mar 14; Vol. 25 (1), pp. 36. Date of Electronic Publication: 2024 Mar 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100940562 Publication Model: Electronic Cited Medium: Internet ISSN: 1129-2377 (Electronic) Linking ISSN: 11292369 NLM ISO Abbreviation: J Headache Pain Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [2018]- : [London, United Kingdom] : BioMed Central Original Publication: Milano : Springer Verlag Italia, c2000-c2017. |
| مواضيع طبية MeSH: | Calcitonin Gene-Related Peptide*/genetics , Receptors, Calcitonin*, Rats ; Female ; Male ; Humans ; Mice ; Animals ; Ganglia, Spinal ; Islet Amyloid Polypeptide/genetics ; In Situ Hybridization, Fluorescence ; Pain ; RNA, Messenger |
| مستخلص: | Background: The upper cervical dorsal root ganglia (DRG) are important for the transmission of sensory information associated with the back of the head and neck, contributing to head pain. Calcitonin receptor (CTR)-based receptors, such as the amylin 1 (AMY Methods: CTR, CGRP, and amylin immunofluorescence was examined relative to neural markers in C1/2 DRG from male and female mice, rats, and human cases. Immunofluorescence was supported by RNA-fluorescence in situ hybridization examining amylin mRNA distribution in rat DRG. Results: Amylin immunofluorescence was observed in neuronal soma and fibres. Amylin mRNA (Iapp) was also detected. Amylin and CGRP co-expression was observed in 19% (mouse), 17% (rat), and 36% (human) of DRG neurons in distinct vesicle-like neuronal puncta from one another. CTR immunoreactivity was present in DRG neurons, and both peptides produced receptor signalling in primary DRG cell cultures. CTR-positive neurons frequently co-expressed amylin and/or CGRP (66% rat; 84% human), with some sex differences. Conclusions: Amylin and CGRP could both be local peptide agonists for CTR-based receptors in upper cervical DRG, potentially acting through autocrine and/or paracrine signalling mechanisms to modulate neuron function. Amylin and its receptors could represent novel pain targets. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | RF1 NS113839 United States NS NINDS NIH HHS; RF1NS113839 United States NS NINDS NIH HHS |
| فهرسة مساهمة: | Keywords: AMY receptors; Amylin; Calcitonin gene-related peptide; Dorsal root ganglia; G protein-coupled receptors; Headache; Neuropeptides; Nociception |
| المشرفين على المادة: | JHB2QIZ69Z (Calcitonin Gene-Related Peptide) 0 (Receptors, Calcitonin) 0 (Islet Amyloid Polypeptide) 0 (RNA, Messenger) |
| تواريخ الأحداث: | Date Created: 20240314 Date Completed: 20240315 Latest Revision: 20240316 |
| رمز التحديث: | 20240316 |
| مُعرف محوري في PubMed: | PMC10938748 |
| DOI: | 10.1186/s10194-024-01744-z |
| PMID: | 38481170 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1129-2377 |
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| DOI: | 10.1186/s10194-024-01744-z |