دورية أكاديمية
The burden of dengue and force of infection among children in Kerala, India; seroprevalence estimates from Government of Kerala-WHO Dengue study.
| العنوان: | The burden of dengue and force of infection among children in Kerala, India; seroprevalence estimates from Government of Kerala-WHO Dengue study. |
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| المؤلفون: | Indu PS; Department of Community Medicine, Govt Medical College, Thiruvananthapuram, Kerala University of Health Sciences, India., Anish TS; Department of Community Medicine, Govt Medical College, Thiruvananthapuram, Kerala University of Health Sciences, India., Chintha S; Department of Community Medicine, Govt Medical College, Thiruvananthapuram, Kerala University of Health Sciences, India., Libu GK; Department of Community Medicine, Govt Medical College, Thiruvananthapuram, Kerala University of Health Sciences, India., Tony L; Department of Community Medicine, Govt Medical College, Thiruvananthapuram, Kerala University of Health Sciences, India., Siju NS; Department of Community Medicine, Govt Medical College, Thiruvananthapuram, Kerala University of Health Sciences, India., Sreekumar E; Molecular Virology Laboratory, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India.; Institute of Advanced Virology (IAV), Bio 360 Life Sciences Park, Thonnakkal, Thiruvananthapuram, Kerala, India., Santhoshkumar A; Department of Paediatrics, Govt Medical College, Thiruvananthapuram, Kerala University of Health Sciences, India., Aravind R; Department of Infectious Diseases, Govt Medical College, Thiruvananthapuram, Kerala University of Health Sciences, India., Saradadevi KL; Department of Microbiology, Govt Medical College, Thiruvananthapuram, Kerala University of Health Sceinces, India., Sunija S; State Public Health Lab, Kerala, India., Johnson J; State Public Health Lab, Kerala, India., Anupriya MG; Molecular Virology Laboratory, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India., Mathew T; Directorate of Medical Education, Kerala, India., Reena KJ; Directorate of Health Services, Kerala, India., Meenakshy V; Directorate of Health Services, Kerala, India., Namitha P; Department of Community Medicine, Govt Medical College, Thiruvananthapuram, Kerala University of Health Sciences, India., Kumar NP; Indian Council of Medical Research - Vector Control Research Centre, India., Kumari R; India Country Office-WHO, New Delhi, India., Mohamed AJ; South East Asia Region Office-WHO, New Delhi, India., Nagpal B; South East Asia Region Office-WHO, New Delhi, India., Sarkar S; South East Asia Region Office-WHO, New Delhi, India., Sadanandan R; Department of Health and Family Welfare, Govt of Kerala, India., Velayudhan R; Department of Control of Neglected Tropical Diseases, WHO, Geneva, Switzerland. |
| المصدر: | The Lancet regional health. Southeast Asia [Lancet Reg Health Southeast Asia] 2023 Dec 11; Vol. 22, pp. 100337. Date of Electronic Publication: 2023 Dec 11 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 9918419282806676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-3682 (Electronic) Linking ISSN: 27723682 NLM ISO Abbreviation: Lancet Reg Health Southeast Asia Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Elsevier Ltd., [2022]- |
| مستخلص: | Background: Dengue shows high geographic heterogeneity within and across endemic countries. In the context of increasing burden and predicted outbreaks due to climate change, understanding the heterogeneity will enable us to develop region specific targeted interventions, including vaccination. World Health Organisation (WHO) suggests standard methodologies to study the burden and heterogeneity at national and subnational levels. Regional studies with robust and standard methodology to capture heterogeneity are scarce. We estimated the seroprevalence of dengue in children aged 9-12 years and the force of infection in Kerala, India, from where Zika cases also have been reported recently. Methods: We conducted a school-based cross-sectional survey in 38 clusters; selected by stratified random sampling, representing rural, urban, high burden and low-burden administrative units. Validation of Indirect IgG ELISA was done by Plaque Reduction Neutralization Test (PRNT Results: Among 5236 children tested, 1521 were positive for anti-dengue IgG antibody. The overall seroprevalence in the state was 29% (95% CI 24.1-33.9). The validity corrected seroprevalence was 30.9% in the overall sample, 46.9% in Thiruvananthapuram, 26.9% in Kozhikkode and 24.9% in Kollam. Age-specific seroprevalence increased with age; 25.7% at 9 years, 29.5% at 10 years, 30.9% at 11 years and 33.9% at 12 years. Seroprevalence varied widely across clusters (16.1%-71.4%). The estimated force of infection was 3.3/100 person-years and the seroconversion rate was 4.8/100 person-years. 90% of children who tested positive were not aware of dengue infection. All the four serotypes were identified in PRNT and 40% of positive samples had antibodies against multiple serotypes. Interpretation: The study validates the WHO methodology for dengue serosurveys and confirms its feasibility in a community setting. The overall seroprevalence in the 9-12 year age group is low to moderate in Kerala; there are regional variations; high burden and low burden clusters co-exist in the same districts. The actual burden of dengue exceeds the reported numbers. Heterogeneity in prevalence, the high proportion of inapparent dengue and the hyperendemic situation suggest the need for region-specific and targeted interventions, including vaccination. Funding: World Health Organization. Competing Interests: None. (© 2023 The Authors.) |
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| معلومات مُعتمدة: | 001 International WHO_ World Health Organization |
| فهرسة مساهمة: | Keywords: Burden of dengue: force of infection; Govt of Kerala-WHO Dengue study; Seroconversion in dengue; Seroprevalence of dengue; Serprevalence of dengue in children; Validation of IgG against PRNT, Plaque Reduction Neutralisation Test |
| تواريخ الأحداث: | Date Created: 20240314 Latest Revision: 20240420 |
| رمز التحديث: | 20240420 |
| مُعرف محوري في PubMed: | PMC10934323 |
| DOI: | 10.1016/j.lansea.2023.100337 |
| PMID: | 38482148 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2772-3682 |
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| DOI: | 10.1016/j.lansea.2023.100337 |