دورية أكاديمية
أعرض في EDS

Plasma Metabolites and Life's Simple 7 in REGARDS.

التفاصيل البيبلوغرافية
العنوان: Plasma Metabolites and Life's Simple 7 in REGARDS.
المؤلفون: Kijpaisalratana N; Department of Neurology, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (N.K., Z.A., W.T.K.).; Division of Neurology, Department of Medicine (N.K.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Division of Academic Affairs (N.K.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Ament Z; Department of Neurology, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (N.K., Z.A., W.T.K.).; Department of Neurology, Massachusetts General Hospital, Boston (Z.A., A.-L.G.G., W.T.K.)., Patki A; Department of Epidemiology (A.P., A.C.J., C.A.C., M.R.I.), School of Public Health, University of Alabama at Birmingham., Bhave VM; Harvard Medical School, Boston, MA (V.M.B., W.T.K.)., Jones AC; Department of Epidemiology (A.P., A.C.J., C.A.C., M.R.I.), School of Public Health, University of Alabama at Birmingham., Couch CA; Department of Epidemiology (A.P., A.C.J., C.A.C., M.R.I.), School of Public Health, University of Alabama at Birmingham., Garcia Guarniz AL; Department of Neurology, Massachusetts General Hospital, Boston (Z.A., A.-L.G.G., W.T.K.)., Cushman M; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington (M.C.)., Long DL; Department of Biostatistics (D.L.L., S.E.J.), School of Public Health, University of Alabama at Birmingham., Judd SE; Department of Biostatistics (D.L.L., S.E.J.), School of Public Health, University of Alabama at Birmingham., Irvin MR; Department of Epidemiology (A.P., A.C.J., C.A.C., M.R.I.), School of Public Health, University of Alabama at Birmingham., Kimberly WT; Department of Neurology, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (N.K., Z.A., W.T.K.).; Department of Neurology, Massachusetts General Hospital, Boston (Z.A., A.-L.G.G., W.T.K.).; Harvard Medical School, Boston, MA (V.M.B., W.T.K.).
المصدر: Stroke [Stroke] 2024 May; Vol. 55 (5), pp. 1191-1199. Date of Electronic Publication: 2024 Mar 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: In Process; MEDLINE
أسماء مطبوعة: Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins
Original Publication: Dallas : American Heart Association
مستخلص: Background: The American Heart Association's Life's Simple 7 (LS7) is a health metric that captures important factors associated with cardiovascular and cerebrovascular health. Previous studies highlight the potential of plasma metabolites to serve as a marker for lifestyle and health behavior that could be a target for stroke prevention. The objectives of this study were to identify metabolites that were associated with LS7 and incident ischemic stroke and mediate the relationship between the two.
Methods: Targeted metabolomic profiling of 162 metabolites by liquid chromatography-tandem mass spectrometry was used to identify candidate metabolites in a stroke case-cohort nested within the REGARDS study (Reasons for Geographic and Racial Differences in Stroke). Weighted linear regression and weighted Cox proportional hazard models were used to identify metabolites that were associated with LS7 and incident ischemic stroke, respectively. Effect measures were based on a 1-SD change in metabolite level. Metabolite mediators were examined using inverse odds ratio weighting mediation analysis.
Results: The study comprised 1075 ischemic stroke cases and 968 participants in the random cohort sample. Three out of 162 metabolites were associated with the overall LS7 score including guanosine (β, -0.46 [95% CI, -0.65 to -0.27]; P =2.87×10 -6 ), cotinine (β, -0.49 [95% CI, -0.70 to -0.28]; P =7.74×10 -6 ), and acetylneuraminic acid (β, -0.59 [95% CI, -0.77 to -0.42]; P =4.29×10 -11 ). Guanosine (hazard ratio, 1.47 [95% CI, 1.31-1.65]; P =6.97×10 -11 ), cotinine (hazard ratio, 1.30 [95% CI, 1.16-1.44]; P =2.09×10 -6 ), and acetylneuraminic acid (hazard ratio, 1.29 [95% CI, 1.15-1.45]; P =9.24×10 -6 ) were associated with incident ischemic stroke. The mediation analysis identified guanosine (27% mediation, indirect effect; P =0.002), cotinine (30% mediation, indirect effect; P =0.004), and acetylneurminic acid (22% mediation, indirect effect; P =0.041) partially mediated the relationship between LS7 and ischemic stroke.
Conclusions: We identified guanosine, cotinine, and acetylneuraminic acid that were associated with LS7, incident ischemic stroke, and mediated the relationship between LS7 and ischemic stroke.
Competing Interests: Disclosures Dr Kimberly received research grant support from Biogen, Hyperfine Research, Inc, and NControl Therapeutics; has served as a consultant for Acasti Pharma, Inc, and Astrocyte Pharmaceuticals; has equity in Acasti Pharma, Inc, and Woolsey Pharmaceuticals; and has a patent pending for No. 16/486,687, METHODS AND COMPOSITIONS FOR TREATING A BRAIN INJURY licensed to NControl Therapeutics, all for work unrelated to this article. Dr Long received research grants from the National Institutes of Health, the Centers for Disease Control and Prevention, and the Patient-Centered Outcomes Research Institute and received investigator-initiated research support from Amgen, Inc, for work unrelated to this article. Dr Judd received compensation from the National Institutes of Health Clinical Center for data and safety monitoring services. The other authors report no conflicts.
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معلومات مُعتمدة: P20 GM135007 United States GM NIGMS NIH HHS; R01 NS099209 United States NS NINDS NIH HHS; U01 NS041588 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: biomarker; blood glucose; blood pressure; body mass index; clinical relevance; metabolome; stroke
تواريخ الأحداث: Date Created: 20240314 Latest Revision: 20240426
رمز التحديث: 20240426
مُعرف محوري في PubMed: PMC11039367
DOI: 10.1161/STROKEAHA.123.044714
PMID: 38482689
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4628
DOI:10.1161/STROKEAHA.123.044714