دورية أكاديمية
أعرض في EDS

Preliminary Characterization of Age and Chronic Low Back Pain Effects on Multimodal Pain Sensitivity: A Comparison Study in Older Adults with and Without Chronic Low Back Pain.

التفاصيل البيبلوغرافية
العنوان: Preliminary Characterization of Age and Chronic Low Back Pain Effects on Multimodal Pain Sensitivity: A Comparison Study in Older Adults with and Without Chronic Low Back Pain.
المؤلفون: Knox PJ; Department of Physical Therapy, University of Delaware, Newark, Delaware., Simon CB; Department of Orthopaedic Surgery, Physical Therapy Division, Duke University, Durham, North Carolina., Hicks GE; Department of Physical Therapy, University of Delaware, Newark, Delaware.
المصدر: The journal of pain [J Pain] 2024 Aug; Vol. 25 (8), pp. 104509. Date of Electronic Publication: 2024 Mar 12.
نوع المنشور: Journal Article; Comparative Study
اللغة: English
بيانات الدورية: Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 100898657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-8447 (Electronic) Linking ISSN: 15265900 NLM ISO Abbreviation: J Pain Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : Churchill Livingstone, c2000-
مواضيع طبية MeSH: Low Back Pain*/physiopathology , Low Back Pain*/complications , Chronic Pain*/physiopathology , Chronic Pain*/diagnosis , Pain Threshold*/physiology , Pain Measurement* , Aging*/physiology, Humans ; Aged ; Male ; Female ; Cross-Sectional Studies ; Adult ; Middle Aged ; Young Adult ; Aged, 80 and over ; Reproducibility of Results
مستخلص: Though pain sensitivity impairments contribute to chronic pain in younger adults, it is unclear if pain hypersensitivity manifests with aging and is heightened in the geriatric chronic low back pain population. The cross-sectional study preliminarily addressed this gap by measuring pain sensitivity in older adults with chronic low back pain (n = 25) as well as pain-free sex-matched older (n = 25) and younger adults (n = 25). Pain sensitivity was quantified by 8 distinct measures that were subdivided as static (ie, pressure pain thresholds, heat pain thresholds, fixed mechanical pain, and fixed cold pain) and dynamic pain sensitivity (ie, mechanical temporal summation, thermal ramp and hold, heat pain aftersensations, and conditioned pain modulation). Test-retest reliability values for pain sensitivity ranged from moderate to excellent (intraclass correlation coefficients ≥ .500; p's < .05). The main effect for the group was significant (partial η 2 = .413, P < .001), revealing between-group differences in pain sensitivity on 5 out of 8 tests (p's ≤ .043). Predominantly, both older adult groups demonstrated increased pain facilitation and decreased pain inhibition during dynamic pain sensitivity testing compared to pain-free younger adults (p's ≤ .044). Despite qualitative differences, static and dynamic pain sensitivity responses were statistically similar between older adults with and without chronic LBP (p's > .05). Findings suggest pain sensitivity can be reliably measured in older adults and that pain hypersensitivity develops with chronological aging, providing partial support for the theory that pain hypersensitivity may impact geriatric chronic pain populations. Further study is needed to more definitively parse out whether pain hypersensitivity is comparatively heightened in older adults with chronic LBP beyond the influence of chronological aging. PERSPECTIVE: This article establishes that surrogate measures of centrally mediated pain sensitization are heightened with aging. Impaired endogenous pain modulation may influence chronic pain development, maintenance, treatment efficacy, and/or ensuing disability, necessitating research to comprehensively characterize how pain hypersensitivity contributes to geriatric chronic pain conditions.
(Copyright © 2024 United States Association for the Study of Pain, Inc. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: F30 AG081010 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Central sensitization; Chronic pain; Geriatrics; Low back pain; Pain measurement
تواريخ الأحداث: Date Created: 20240314 Date Completed: 20240728 Latest Revision: 20240730
رمز التحديث: 20240730
مُعرف محوري في PubMed: PMC11283989
DOI: 10.1016/j.jpain.2024.03.005
PMID: 38484855
قاعدة البيانات: MEDLINE
الوصف
تدمد:1528-8447
DOI:10.1016/j.jpain.2024.03.005