دورية أكاديمية
The effect of myeloablative radiation on urinary bladder mast cells.
| العنوان: | The effect of myeloablative radiation on urinary bladder mast cells. |
|---|---|
| المؤلفون: | Smith J; Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, 4226, Australia., Tan JKH; Clem Jones Centre for Regenerative Medicine, Bond University, Gold Coast, QLD, 4226, Australia., Short C; Clem Jones Centre for Regenerative Medicine, Bond University, Gold Coast, QLD, 4226, Australia., O'Neill H; Clem Jones Centre for Regenerative Medicine, Bond University, Gold Coast, QLD, 4226, Australia., Moro C; Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, 4226, Australia. cmoro@bond.edu.au. |
| المصدر: | Scientific reports [Sci Rep] 2024 Mar 14; Vol. 14 (1), pp. 6219. Date of Electronic Publication: 2024 Mar 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Urinary Bladder* , Cystitis*/etiology, Mice ; Animals ; Mast Cells/physiology ; Mice, Inbred C57BL ; Pelvis |
| مستخلص: | Radiation-induced cystitis is an inflammatory condition affecting the urinary bladder, which can develop as a side effect of abdominopelvic radiotherapy, specifically external-beam radiation therapy or myeloablative radiotherapy. A possible involvement of mast cells in the pathophysiology of radiation-induced cystitis has been indicated in cases of external-beam radiation therapy; however, there is no evidence that these findings apply to the myeloablative aetiology. As such, this study investigated potential changes to urinary bladder mast cell prevalence when exposed to myeloablative radiation. Lethally irradiated C57BL/6J mice that received donor rescue bone marrow cells exhibited an increased mast cell frequency amongst host leukocytes 1 week following irradiation. By 4 weeks, no significant difference in either frequency or cell density was observed. However mast cell diameter was smaller, and a significant increase in mast cell number in the adventitia was observed. This study highlights that mast cells constitute a significant portion of the remaining host leukocyte population following radiation exposure, with changes to mast cell distribution and decreased cell diameter four weeks following radiation-induced injury. (© 2024. The Author(s).) |
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| تواريخ الأحداث: | Date Created: 20240315 Date Completed: 20240318 Latest Revision: 20240318 |
| رمز التحديث: | 20240318 |
| مُعرف محوري في PubMed: | PMC10940702 |
| DOI: | 10.1038/s41598-024-56655-5 |
| PMID: | 38485999 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-024-56655-5 |