دورية أكاديمية
Changes in spatial self-consciousness elicit grid cell-like representation in the entorhinal cortex.
| العنوان: | Changes in spatial self-consciousness elicit grid cell-like representation in the entorhinal cortex. |
|---|---|
| المؤلفون: | Moon HJ; Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Geneva 1202, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Lausanne 1015, Switzerland.; Bionics Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea., Albert L; Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Geneva 1202, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Lausanne 1015, Switzerland., De Falco E; Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Geneva 1202, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Lausanne 1015, Switzerland., Tasu C; Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Geneva 1202, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Lausanne 1015, Switzerland., Gauthier B; Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Geneva 1202, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Lausanne 1015, Switzerland.; Clinical Research Unit, Cantonal Hospital, Neuchâtel 2000, Switzerland., Park HD; Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Geneva 1202, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Lausanne 1015, Switzerland.; Department of Brain and Cognitive Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea., Blanke O; Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Geneva 1202, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (École Polytechnique Fédérale de Lausanne), Lausanne 1015, Switzerland.; Department of Clinical Neurosciences, University Hospital Geneva, Geneva 1205, Switzerland. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Mar 19; Vol. 121 (12), pp. e2315758121. Date of Electronic Publication: 2024 Mar 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Grid Cells*/physiology , Illusions*/physiology , Spatial Navigation*/physiology, Humans ; Entorhinal Cortex/physiology ; Consciousness ; Touch |
| مستخلص: | Grid cells in the entorhinal cortex (EC) encode an individual's location in space, integrating both environmental and multisensory bodily cues. Notably, body-derived signals are also primary signals for the sense of self. While studies have demonstrated that continuous application of visuo-tactile bodily stimuli can induce perceptual shifts in self-location, it remains unexplored whether these illusory changes suffice to trigger grid cell-like representation (GCLR) within the EC, and how this compares to GCLR during conventional virtual navigation. To address this, we systematically induced illusory drifts in self-location toward controlled directions using visuo-tactile bodily stimulation, while maintaining the subjects' visual viewpoint fixed (absent conventional virtual navigation). Subsequently, we evaluated the corresponding GCLR in the EC through functional MRI analysis. Our results reveal that illusory changes in perceived self-location (independent of changes in environmental navigation cues) can indeed evoke entorhinal GCLR, correlating in strength with the magnitude of perceived self-location, and characterized by similar grid orientation as during conventional virtual navigation in the same virtual room. These data demonstrate that the same grid-like representation is recruited when navigating based on environmental, mainly visual cues, or when experiencing illusory forward drifts in self-location, driven by perceptual multisensory bodily cues. Competing Interests: Competing interests statement:The authors declare no competing interest. |
| References: | Neuroimage. 2010 Oct 15;53(1):1-15. (PMID: 20547229) Cognition. 2015 Nov;144:49-57. (PMID: 26231086) J Neurosci. 2007 Jun 6;27(23):6141-9. (PMID: 17553986) Nature. 2010 Feb 4;463(7281):657-61. (PMID: 20090680) Curr Biol. 2011 Jul 12;21(13):1118-22. (PMID: 21683596) J Neurosci. 2016 Aug 10;36(32):8453-60. (PMID: 27511016) Nat Neurosci. 2013 Sep;16(9):1188-90. (PMID: 23912946) Sci Rep. 2020 Apr 22;10(1):6802. (PMID: 32321976) Nature. 1998 Apr 9;392(6676):598-601. (PMID: 9560155) N Engl J Med. 2007 Nov 1;357(18):1829-33. (PMID: 17978291) J Cogn Neurosci. 2013 Jul;25(7):1008-19. (PMID: 23489142) Science. 2018 Nov 9;362(6415):. (PMID: 30409861) PLoS One. 2021 Jan 25;16(1):e0233243. (PMID: 33493178) Sci Rep. 2021 Jul 28;11(1):15376. (PMID: 34321591) Conscious Cogn. 2013 Sep;22(3):779-87. (PMID: 23727712) Neuroimage. 2008 May 1;40(4):1902-11. (PMID: 18325789) Science. 2007 Aug 24;317(5841):1048. (PMID: 17717177) Nature. 2002 Sep 19;419(6904):269-70. (PMID: 12239558) Science. 2015 Oct 23;350(6259):430-3. (PMID: 26494756) Commun Biol. 2022 May 2;5(1):406. (PMID: 35501331) Nature. 2005 Aug 11;436(7052):801-6. (PMID: 15965463) Elife. 2016 Aug 30;5:. (PMID: 27572056) Curr Biol. 2018 Apr 2;28(7):1108-1115.e6. (PMID: 29551413) Science. 2016 Jun 17;352(6292):1464-1468. (PMID: 27313047) Hum Brain Mapp. 2014 Jan;35(1):248-56. (PMID: 22936605) Nat Rev Neurosci. 2012 Oct;13(10):713-26. (PMID: 22992647) Annu Rev Neurosci. 2008;31:69-89. (PMID: 18284371) PLoS One. 2009 Aug 05;4(8):e6488. (PMID: 19654862) J Neurosci. 2013 Apr 3;33(14):6133-42. (PMID: 23554494) Neurosci Biobehav Rev. 2019 Apr;99:138-159. (PMID: 30685486) J Cogn Neurosci. 2021 Feb;33(2):159-166. (PMID: 33054553) Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5. (PMID: 10984517) Annu Rev Neurosci. 2016 Jul 8;39:19-40. (PMID: 27023731) Nat Commun. 2023 Jan 31;14(1):231. (PMID: 36720865) Science. 2007 Aug 24;317(5841):1096-9. (PMID: 17717189) J Vis Exp. 2014 Jul 02;(89):. (PMID: 25046210) Curr Biol. 2015 Jun 1;25(11):1416-25. (PMID: 25936550) Conscious Cogn. 2013 Dec;22(4):1239-52. (PMID: 24025475) Trends Cogn Sci. 2019 May;23(5):377-388. (PMID: 30826212) Q J Exp Psychol (Hove). 2017 Apr;70(4):597-609. (PMID: 27100132) Neuron. 2015 Oct 7;88(1):145-66. (PMID: 26447578) AJNR Am J Neuroradiol. 1998 Apr;19(4):659-71. (PMID: 9576651) Front Behav Neurosci. 2018 Jan 04;11:253. (PMID: 29354038) Elife. 2015 Jun 08;4:. (PMID: 26052748) Nat Commun. 2019 Feb 7;10(1):630. (PMID: 30733457) Front Psychol. 2018 Sep 04;9:1475. (PMID: 30245648) Curr Biol. 2016 Apr 4;26(7):R277-9. (PMID: 27046812) Nat Neurosci. 2018 Aug;21(8):1096-1106. (PMID: 30038279) Trends Cogn Sci. 2015 Jan;19(1):6-12. (PMID: 25524273) Ann Phys Rehabil Med. 2017 Jun;60(3):198-207. (PMID: 27318928) Nature. 2007 Mar 8;446(7132):190-4. (PMID: 17322902) Front Neuroinform. 2017 Jul 21;11:47. (PMID: 28785214) Neuron. 2011 Apr 28;70(2):363-74. (PMID: 21521620) Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12846-51. (PMID: 23858436) Cereb Cortex. 2012 Jan;22(1):166-74. (PMID: 21625010) Curr Biol. 2016 Mar 21;26(6):842-7. (PMID: 26972318) Nat Neurosci. 2014 Nov;17(11):1598-606. (PMID: 25282616) |
| معلومات مُعتمدة: | 320030_188798 Switzerland SNSF_ Swiss National Science Foundation |
| فهرسة مساهمة: | Keywords: fMRI; grid cells; navigation; self-consciousness; virtual reality |
| تواريخ الأحداث: | Date Created: 20240315 Date Completed: 20240318 Latest Revision: 20240327 |
| رمز التحديث: | 20240327 |
| مُعرف محوري في PubMed: | PMC10962966 |
| DOI: | 10.1073/pnas.2315758121 |
| PMID: | 38489383 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
|---|---|
| DOI: | 10.1073/pnas.2315758121 |