دورية أكاديمية
Iron homeostasis in older adults: balancing nutritional requirements and health risks.
| العنوان: | Iron homeostasis in older adults: balancing nutritional requirements and health risks. |
|---|---|
| المؤلفون: | Zeidan RS; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA; Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA., Martenson M; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA., Tamargo JA; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA., McLaren C; Department of Clinical and Health Psychology, College of Health and Health Professions, University of Florida, Gainesville, Florida, USA., Ezzati A; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA; Department of Food, Nutrition, Dietetics and Health, Kansas State University, Manhattan, KS, USA., Lin Y; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA., Yang JJ; UF Health Cancer Center, Gainesville, FL, USA; Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, USA., Yoon HS; UF Health Cancer Center, Gainesville, FL, USA; Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, USA., McElroy T; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA; Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA., Collins JF; Department of Food Science & Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA., Leeuwenburgh C; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA., Mankowski RT; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA., Anton S; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, College of Health and Health Professions, University of Florida, Gainesville, Florida, USA. Electronic address: santon@ufl.edu. |
| المصدر: | The journal of nutrition, health & aging [J Nutr Health Aging] 2024 May; Vol. 28 (5), pp. 100212. Date of Electronic Publication: 2024 Mar 14. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Masson SAS on behalf of SERDI Publisher Country of Publication: France NLM ID: 100893366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1760-4788 (Electronic) Linking ISSN: 12797707 NLM ISO Abbreviation: J Nutr Health Aging Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : [Paris, France] : Elsevier Masson SAS on behalf of SERDI Publisher Original Publication: Paris, France : New York, NY : Serdi Publisher ; Springer Pub. Co., |
| مواضيع طبية MeSH: | Homeostasis*/physiology , Nutritional Requirements* , Iron, Dietary*/administration & dosage , Iron*/metabolism, Humans ; Aged ; Aging/physiology ; Nutritional Status ; Anemia, Iron-Deficiency/prevention & control ; Iron Deficiencies ; Iron Overload |
| مستخلص: | Iron plays a crucial role in many physiological processes, including oxygen transport, bioenergetics, and immune function. Iron is assimilated from food and also recycled from senescent red blood cells. Iron exists in two dietary forms: heme (animal based) and non-heme (mostly plant based). The body uses iron for metabolic purposes, and stores the excess mainly in splenic and hepatic macrophages. Physiologically, iron excretion in humans is inefficient and not highly regulated, so regulation of intestinal absorption maintains iron homeostasis. Iron losses occur at a steady rate via turnover of the intestinal epithelium, blood loss, and exfoliation of dead skin cells, but overall iron homeostasis is tightly controlled at cellular and systemic levels. Aging can have a profound impact on iron homeostasis and induce a dyshomeostasis where iron deficiency or overload (sometimes both simultaneously) can occur, potentially leading to several disorders and pathologies. To maintain physiologically balanced iron levels, reduce risk of disease, and promote healthy aging, it is advisable for older adults to follow recommended daily intake guidelines and periodically assess iron levels. Clinicians can evaluate body iron status using different techniques but selecting an assessment method primarily depends on the condition being examined. This review provides a comprehensive overview of the forms, sources, and metabolism of dietary iron, associated disorders of iron dyshomeostasis, assessment of iron levels in older adults, and nutritional guidelines and strategies to maintain iron balance in older adults. (Copyright © 2024 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aging; Homeostasis; Iron; Nutrition |
| المشرفين على المادة: | 0 (Iron, Dietary) E1UOL152H7 (Iron) |
| تواريخ الأحداث: | Date Created: 20240315 Date Completed: 20240601 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| DOI: | 10.1016/j.jnha.2024.100212 |
| PMID: | 38489995 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1760-4788 |
|---|---|
| DOI: | 10.1016/j.jnha.2024.100212 |