دورية أكاديمية
أعرض في EDS

Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease.

التفاصيل البيبلوغرافية
العنوان: Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease.
المؤلفون: Khrom M; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Long M; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina., Dube S; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Robbins L; Palmetto Digestive Health Specialists, Charleston, South Carolina., Botwin GJ; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Yang S; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Mengesha E; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Li D; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Naito T; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Bonthala NN; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Ha C; Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California., Melmed G; Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California., Rabizadeh S; Department of Pediatrics, Pediatric Inflammatory Bowel Disease Program, Cedars-Sinai Medical Center, Los Angeles, California., Syal G; Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California., Vasiliauskas E; Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California., Ziring D; Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California., Brant SR; Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey., Cho J; Icahn School of Medicine at Mount Sinai, Dr Henry D. Janowitz Division of Gastroenterology, New York, New York., Duerr RH; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Rioux J; Department of Medicine, Université de Montréal and Research Center, Montreal Heart Institute, Montréal, Québec, Canada., Schumm P; Department of Public Health Sciences, University of Chicago, Chicago, Illinois., Silverberg M; University of Toronto, Samuel Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Ananthakrishnan AN; Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts., Faubion WA; Mayo Clinic, Rochester, Minnesota., Jabri B; University of Chicago, Pritzker School of Medicine, Chicago, Illinois., Lira SA; Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Newberry RD; Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Sandler RS; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Kugathasan S; Children's Healthcare of Atlanta Combined Center for Pediatric Inflammatory Bowel Disease, Atlanta, Georgia; Emory School of Medicine, Atlanta, Georgia., Hercules D; Emory School of Medicine, Atlanta, Georgia., Targan SR; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Sartor RB; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina., Haritunians T; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., McGovern DPB; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: Dermot.McGovern@cshs.org.
المصدر: Gastroenterology [Gastroenterology] 2024 Jul; Vol. 167 (2), pp. 315-332. Date of Electronic Publication: 2024 Mar 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia, PA : W.B. Saunders
Original Publication: Baltimore.
مواضيع طبية MeSH: Cholangitis, Sclerosing*/immunology , Cholangitis, Sclerosing*/genetics , Cholangitis, Sclerosing*/diagnosis , Cholangitis, Sclerosing*/complications , Colitis, Ulcerative*/immunology , Colitis, Ulcerative*/genetics , Colitis, Ulcerative*/diagnosis , Crohn Disease*/immunology , Crohn Disease*/genetics , Crohn Disease*/diagnosis, Humans ; Female ; Male ; Adult ; Middle Aged ; Adolescent ; Risk Factors ; Child ; Spondylitis, Ankylosing/genetics ; Spondylitis, Ankylosing/immunology ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/complications ; Genetic Predisposition to Disease ; Young Adult ; Sex Factors ; Skin Diseases/etiology ; Skin Diseases/immunology ; Skin Diseases/genetics ; Eye Diseases/etiology ; Eye Diseases/immunology ; Eye Diseases/diagnosis ; Eye Diseases/genetics ; Eye Diseases/epidemiology ; Phenotype ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/diagnosis ; Logistic Models ; Aged
مستخلص: Background & Aims: Patients with inflammatory bowel disease (IBD) frequently develop extraintestinal manifestations (EIMs) that contribute substantially to morbidity. We assembled the largest multicohort data set to date to investigate the clinical, serologic, and genetic factors associated with EIM complications in IBD.
Methods: Data were available in 12,083 unrelated European ancestry IBD cases with presence or absence of EIMs (eg, ankylosing spondylitis [ankylosing spondylitis and sacroiliitis], primary sclerosing cholangitis [PSC], peripheral arthritis, and skin and ocular manifestations) across 4 cohorts (Cedars-Sinai Medical Center, National Institute for Diabetes and Digestive and Kidney Diseases IBD Genetics Consortium, Sinai Helmsley Alliance for Research Excellence Consortium, and Risk Stratification and Identification of Immunogenetic and Microbial Markers of Rapid Disease Progression in Children with Crohn's Disease cohort). Clinical and serologic parameters were analyzed by means of univariable and multivariable regression analyses using a mixed-effects model. Within-case logistic regression was performed to assess genetic associations.
Results: Most EIMs occurred more commonly in female subjects (overall EIM: P = 9.0E-05, odds ratio [OR], 1.2; 95% CI, 1.1-1.4), with CD (especially colonic disease location; P = 9.8E-09, OR, 1.7; 95% CI, 1.4-2.0), and in subjects who required surgery (both CD and UC; P = 3.6E-19, OR, 1.7; 95% CI, 1.5-1.9). Smoking increased risk of EIMs except for PSC, where there was a "protective" effect. Multiple serologic associations were observed, including with PSC (anti-nuclear cytoplasmic antibody; IgG and IgA, anti-Saccharomyces cerevisiae antibodies; and anti-flagellin) and any EIM (anti-nuclear cytoplasmic antibody; IgG and IgA, anti-Saccharomyces cerevisiae antibodies; and anti-Pseudomonas fluorescens-associated sequence). We identified genome-wide significant associations within major histocompatibility complex (ankylosing spondylitis and sacroiliitis, P = 1.4E-15; OR, 2.5; 95% CI, 2.0-3.1; PSC, P = 2.7E-10; OR, 2.8; 95% CI, 2.0-3.8; ocular, P = 2E-08, OR, 3.6; 95% CI, 2.3-5.6; and overall EIM, P = 8.4E-09; OR, 2.2; 95% CI, 1.7-2.9) and CPEB4 (skin, P = 2.7E-08; OR, 1.5; 95% CI, 1.3-1.8). Genetic associations implicated tumor necrosis factor, JAK-STAT, and IL6 as potential targets for EIMs. Contrary to previous reports, only 2% of our subjects had multiple EIMs and most co-occurrences were negatively correlated.
Conclusions: We have identified demographic, clinical, and genetic associations with EIMs that revealed underlying mechanisms and implicated novel and existing drug targets-important steps toward a more personalized approach to IBD management.
(Copyright © 2024 AGA Institute. Published by Elsevier Inc. All rights reserved.)
References: Inflamm Bowel Dis. 2014 Jun;20(6):987-94. (PMID: 24739630)
Nat Genet. 2017 Feb;49(2):269-273. (PMID: 27992413)
Gigascience. 2015 Feb 25;4:7. (PMID: 25722852)
Gastroenterology. 2015 Oct;149(5):1163-1176.e2. (PMID: 26255561)
Scand J Gastroenterol. 2015 Mar;50(3):300-5. (PMID: 25535653)
Ann Rheum Dis. 1996 Apr;55(4):268-70. (PMID: 8733445)
World J Gastroenterol. 2006 Aug 14;12(30):4819-31. (PMID: 16937463)
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7. (PMID: 27141961)
Nat Genet. 2017 Feb;49(2):256-261. (PMID: 28067908)
Nature. 2017 Jul 13;547(7662):173-178. (PMID: 28658209)
Gut. 2006 Jun;55(6):749-53. (PMID: 16698746)
Gastroenterology. 2021 Feb;160(3):809-822.e7. (PMID: 33160965)
Inflamm Bowel Dis. 2021 Oct 18;27(10):1602-1609. (PMID: 33300561)
Ann Rheum Dis. 2014 Aug;73(8):1552-7. (PMID: 23727634)
Medicine (Baltimore). 1976 Sep;55(5):401-12. (PMID: 957999)
Inflamm Bowel Dis. 1999 Feb;5(1):61-3; discussion 66-7. (PMID: 10028450)
World J Gastroenterol. 2016 Jan 21;22(3):1304-10. (PMID: 26811667)
Inflamm Bowel Dis. 2007 May;13(5):524-30. (PMID: 17260364)
Inflamm Bowel Dis. 2014 Mar;20(3):525-33. (PMID: 24487271)
Expert Rev Gastroenterol Hepatol. 2019 Apr;13(4):307-317. (PMID: 30791773)
Gastroenterology. 2002 Sep;123(3):714-8. (PMID: 12198697)
Am J Gastroenterol. 2011 Jan;106(1):110-9. (PMID: 20808297)
Gastroenterology. 1996 Jun;110(6):1810-9. (PMID: 8964407)
Eur J Intern Med. 2015 Oct;26(8):563-71. (PMID: 26260744)
Arthritis Res Ther. 2009;11(6):R177. (PMID: 19930665)
Inflamm Bowel Dis. 2009 May;15(5):714-9. (PMID: 19107777)
Nat Rev Gastroenterol Hepatol. 2013 Oct;10(10):585-95. (PMID: 23835489)
Nat Genet. 2013 Jun;45(6):670-5. (PMID: 23603763)
Can J Gastroenterol. 2005 Oct;19(10):603-6. (PMID: 16247522)
Nat Rev Rheumatol. 2020 Jun;16(6):335-345. (PMID: 32327746)
South Med J. 2015 Mar;108(3):139-43. (PMID: 25772045)
Front Immunol. 2021 Jun 24;12:705342. (PMID: 34249014)
Semin Liver Dis. 2006 Feb;26(1):31-41. (PMID: 16496231)
Nat Biotechnol. 2010 May;28(5):495-501. (PMID: 20436461)
Am J Gastroenterol. 2002 Jun;97(6):1458-62. (PMID: 12094865)
Medicine (Baltimore). 2016 Dec;95(51):e5652. (PMID: 28002334)
Gut. 1996 May;38(5):738-41. (PMID: 8707121)
Arthritis Res Ther. 2012 Nov 29;14(6):R261. (PMID: 23194008)
Gastroenterology. 2005 Sep;129(3):827-36. (PMID: 16143122)
Bioinformatics. 2015 Nov 1;31(21):3555-7. (PMID: 26139635)
Curr Opin Organ Transplant. 2019 Apr;24(2):207-211. (PMID: 30694990)
Gastroenterology. 2010 Mar;138(3):1102-11. (PMID: 19944697)
J Crohns Colitis. 2016 Jan;10(1):43-9. (PMID: 26449790)
Am J Gastroenterol. 2001 Apr;96(4):1116-22. (PMID: 11316157)
J Crohns Colitis. 2019 Apr 26;13(5):541-554. (PMID: 30445584)
Nat Genet. 2015 Feb;47(2):172-9. (PMID: 25559196)
Nat Genet. 2016 May;48(5):510-8. (PMID: 26974007)
Gastroenterol Hepatol (N Y). 2011 Apr;7(4):235-41. (PMID: 21857821)
Rev Esp Enferm Dig. 2006 Jul;98(7):510-7. (PMID: 17022700)
معلومات مُعتمدة: P01 DK046763 United States DK NIDDK NIH HHS; U01 DK062413 United States DK NIDDK NIH HHS; U01 DK062431 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Extraintestinal Manifestations; Genetics; Inflammatory Bowel Disease; Serology
تواريخ الأحداث: Date Created: 20240315 Date Completed: 20240622 Latest Revision: 20240626
رمز التحديث: 20240626
مُعرف محوري في PubMed: PMC11193636
DOI: 10.1053/j.gastro.2024.02.026
PMID: 38490347
قاعدة البيانات: MEDLINE
الوصف
تدمد:1528-0012
DOI:10.1053/j.gastro.2024.02.026