دورية أكاديمية
Antarctic fungi produce pigment with antimicrobial and antiparasitic activities.
| العنوان: | Antarctic fungi produce pigment with antimicrobial and antiparasitic activities. |
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| المؤلفون: | Cavalcante SB; Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil., da Silva AF; Bioprocess and Biotechnology Engineering Undergraduate Program, Federal University of Tocantins (UFT), Gurupi, TO, Brazil., Pradi L; Department of Chemistry, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil., Lacerda JWF; Department of Chemistry, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil., Tizziani T; Department of Chemistry, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil., Sandjo LP; Department of Chemistry, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil., Modesto LR; Centre for Agrarian Sciences, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil., de Freitas ACO; Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil., Steindel M; Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil., Stoco PH; Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil., Duarte RTD; Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil., Robl D; Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil. diogo.robl@ufsc.br. |
| المصدر: | Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2024 Jun; Vol. 55 (2), pp. 1251-1263. Date of Electronic Publication: 2024 Mar 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Publishing Country of Publication: Brazil NLM ID: 101095924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4405 (Electronic) Linking ISSN: 15178382 NLM ISO Abbreviation: Braz J Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2019- : Switzerland, AG : Springer International Publishing Original Publication: Rio de Janeiro, RJ, Brasil : Sociedade Brasileira de Microbiologia |
| مواضيع طبية MeSH: | Pigments, Biological*/pharmacology , Pigments, Biological*/biosynthesis , Antiparasitic Agents*/pharmacology, Antarctic Regions ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/metabolism ; Fungi/drug effects ; Fungi/metabolism ; Fungi/classification ; Soil Microbiology ; Bacteria/drug effects ; Bacteria/classification ; Bacteria/metabolism ; Bacteria/isolation & purification ; Bacteria/genetics ; Microbial Sensitivity Tests ; Animals ; Staphylococcus aureus/drug effects |
| مستخلص: | Natural pigments have received special attention from the market and industry as they could overcome the harm to health and the environmental issues caused by synthetic pigments. These pigments are commonly extracted from a wide range of organisms, and when added to products they can alter/add new physical-chemical or biological properties to them. Fungi from extreme environments showed to be a promising source in the search for biomolecules with antimicrobial and antiparasitic potential. This study aimed to isolate fungi from Antarctic soils and screen them for pigment production with antimicrobial and antiparasitic potential, together with other previously isolated strains A total of 52 fungi were isolated from soils in front of the Collins Glacier (Southeast border). Also, 106 filamentous fungi previously isolated from the Collins Glacier (West border) were screened for extracellular pigment production. Five strains were able to produce extracellular pigments and were identified by ITS sequencing as Talaromyces cnidii, Pseudogymnoascus shaanxiensis and Pseudogymnoascus sp. All Pseudogymnoascus spp. (SC04.P3, SC3.P3, SC122.P3 and ACF093) extracts were able to inhibit S. aureus ATCC6538 and two (SC12.P3, SC32.P3) presented activity against Leishmania (L.) infantum, Leishmania amazonensis and Trypanossoma cruzii. Extracts compounds characterization by UPLC-ESI-QToF analysis confirmed the presence of molecules with biological activity such as: Asterric acid, Violaceol, Mollicellin, Psegynamide A, Diorcinol, Thailandolide A. In conclusion, this work showed the potential of Antartic fungal strains from Collins Glacier for bioactive molecules production with activity against Gram positive bacteria and parasitic protozoas. (© 2024. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.) |
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| معلومات مُعتمدة: | Scholarship Conselho Nacional de Desenvolvimento Científico e Tecnológico; Scholarship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| فهرسة مساهمة: | Keywords: Pseudogymnoascus; Talaromyces; Antarctic; Antimicrobial molecules; Natural pigments |
| المشرفين على المادة: | 0 (Pigments, Biological) 0 (Antiparasitic Agents) 0 (Anti-Infective Agents) |
| تواريخ الأحداث: | Date Created: 20240316 Date Completed: 20240605 Latest Revision: 20240608 |
| رمز التحديث: | 20240608 |
| مُعرف محوري في PubMed: | PMC11153455 |
| DOI: | 10.1007/s42770-024-01308-y |
| PMID: | 38492163 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1678-4405 |
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| DOI: | 10.1007/s42770-024-01308-y |