دورية أكاديمية
Frailty and brain changes in older adults without cognitive impairment: A scoping review.
| العنوان: | Frailty and brain changes in older adults without cognitive impairment: A scoping review. |
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| المؤلفون: | Cipolli GC; Postgraduate Program in Gerontology, College of Medical Sciences, State University of Campinas, Campinas, Brazil., Ribeiro IC; Postgraduate Program in Medical Pathophysiology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil., Yasuda CL; Faculty of Medical Sciences, Department of Neurology, State University of Campinas, Campinas, Brazil., Balthazar MLF; Faculty of Medical Sciences, Department of Neurology, State University of Campinas, Campinas, Brazil., Fattori A; Postgraduate Program in Gerontology, College of Medical Sciences, State University of Campinas, Campinas, Brazil; Faculty of Medical Sciences, Department of Internal Medicine, State University of Campinas, Campinas, Brazil., Yassuda MS; Postgraduate Program in Gerontology, College of Medical Sciences, State University of Campinas, Campinas, Brazil; Postgraduate Program in Gerontology, University of São Paulo, São Paulo, Brazil. Electronic address: yassuda@usp.br. |
| المصدر: | Archives of gerontology and geriatrics [Arch Gerontol Geriatr] 2024 Aug; Vol. 123, pp. 105395. Date of Electronic Publication: 2024 Mar 04. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Biomedical Press Country of Publication: Netherlands NLM ID: 8214379 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6976 (Electronic) Linking ISSN: 01674943 NLM ISO Abbreviation: Arch Gerontol Geriatr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Biomedical Press, c1982- |
| مواضيع طبية MeSH: | Frailty* , Brain*/diagnostic imaging , Brain*/pathology, Humans ; Aged ; Frail Elderly ; Cognitive Dysfunction/diagnostic imaging ; Neuroimaging/methods ; Aged, 80 and over |
| مستخلص: | Little is known about changes in the brain associated with frailty, in particular, which brain areas could be related to frailty in older people without cognitive impairment. This scoping review mapped evidence on functional and/or structural brain changes in frail older adults without cognitive impairment. The methodology proposed by the JBI® was used in this study. The search in PubMed, PubMed PMC, BVS/BIREME, EBSCOHOST, Scopus, Web of Science, Embase, and PROQUEST was conducted up to January 2023. Studies included following the population, concepts, context and the screening and data extraction were performed by two independent reviewers. A total of 9,912 records were identified, 5,676 were duplicates and were excluded. The remaining articles were screened; 31 were read in full and 17 articles were included. The results showed that lesions in white matter hyperintensities, reduced volume of the hippocampus, cerebellum, middle frontal gyrus, low gray matter volume, cortical atrophy, decreased connectivity of the supplementary motor area, presence of amyloid-beta peptide (aβ) in the anterior and posterior putamen and precuneus regions were more frequently observed in frail older adults, compared with non-frail individuals. Studies have suggested that such findings may be of neurodegenerative or cerebrovascular origin. The identification of these brain alterations in frail older adults through neuroimaging studies contributes to our understanding of the underlying mechanisms of frailty. Such findings may have implications for the early detection of frailty and implementation of intervention strategies. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aged; Aging; Cerebrum; Cognitive dysfunction; Frailty; Review |
| تواريخ الأحداث: | Date Created: 20240316 Date Completed: 20240604 Latest Revision: 20240606 |
| رمز التحديث: | 20240607 |
| DOI: | 10.1016/j.archger.2024.105395 |
| PMID: | 38492289 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-6976 |
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| DOI: | 10.1016/j.archger.2024.105395 |