دورية أكاديمية
أعرض في EDS

The combination of hydrogen gas and hydrogen-rich solution does not protect against ischemic spinal cord injury in rabbits.

التفاصيل البيبلوغرافية
العنوان: The combination of hydrogen gas and hydrogen-rich solution does not protect against ischemic spinal cord injury in rabbits.
المؤلفون: Yamashita A; Department of Anesthesiology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan., Fukui T; Department of Anesthesiology, NHO Kanmon Medical Center, Yamaguchi, Japan., Yamashita S; Department of Anesthesiology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan., Ishida K; Department of Anesthesiology, Kurashiki Central Hospital, Kurashiki, Japan., Matsumoto M; Department of Anesthesiology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan. mishiyamatsumoto@gmail.com.
المصدر: Journal of anesthesia [J Anesth] 2024 Aug; Vol. 38 (4), pp. 455-463. Date of Electronic Publication: 2024 Mar 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International for the Japan Society of Anesthesiology Country of Publication: Japan NLM ID: 8905667 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-8359 (Electronic) Linking ISSN: 09138668 NLM ISO Abbreviation: J Anesth Subsets: MEDLINE
أسماء مطبوعة: Publication: Tokyo : Springer International for the Japan Society of Anesthesiology
Original Publication: [Tokyo] : Japan Society of Anesthesiology, [1987-
مواضيع طبية MeSH: Hydrogen*/administration & dosage , Hydrogen*/pharmacology , Spinal Cord Ischemia*/prevention & control, Animals ; Rabbits ; Male ; Ringer's Solution/administration & dosage ; Spinal Cord Injuries/prevention & control ; Spinal Cord/drug effects ; Disease Models, Animal ; Administration, Inhalation ; Reperfusion Injury/prevention & control
مستخلص: Purpose: This study aimed to determine whether the combination of H 2 gas inhalation and administration of hydrogen-rich acetated Ringer's solution (HS) could protect against ischemic spinal cord injury in rabbits.
Methods: In Experiment 1, rabbits were randomly assigned to a 1.2% H 2 gas group, HS group, 1.2% H 2 gas + HS group (combination group), or control group (n = 6 per group). The H 2 concentration of HS was 0.65 mM. H 2 was inhaled for 60 min, starting 5 min before reperfusion. HS (20 mL/kg) was divided into six bolus injections at 10-min intervals, starting 5 min before reperfusion. Spinal cord ischemia was produced by occluding the abdominal aorta for 15 min. Neurologic and histopathologic evaluations were performed 7 days after reperfusion. In Experiment 2, H 2 concentrations in spinal cord tissue according to the administration of 1.2% H 2 gas or HS were compared by measuring the electric current through a platinum needle electrode (n = 2). In Experiment 3, rabbits were assigned to a 2% H 2 gas group or control group (n = 6 per group). Spinal cord ischemia was produced and neurologic and histopathologic evaluations were performed as in Experiment 1.
Results: There were no significant differences among the groups in the neurologic and histopathologic outcomes in Experiments 1 and 3. Bolus administration of HS (10 mL) transiently increased the current to only 1/30th and 1/27th of the plateau current with 1.2% H 2 gas inhalation in two animals.
Conclusion: These results suggest that the combination of 1.2% H 2 gas inhalation and administration of a hydrogen-rich solution does not protect against ischemic spinal cord injury and that the increase in H 2 concentration in spinal cord tissue after administration of HS is very low compared to 1.2% H 2 gas inhalation.
(© 2024. The Author(s) under exclusive licence to Japanese Society of Anesthesiologists.)
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فهرسة مساهمة: Keywords: Hydrogen gas; Hydrogen-rich solution; Rabbit; Spinal cord ischemia
المشرفين على المادة: 7YNJ3PO35Z (Hydrogen)
8026-10-6 (Ringer's Solution)
تواريخ الأحداث: Date Created: 20240317 Date Completed: 20240728 Latest Revision: 20240804
رمز التحديث: 20240805
DOI: 10.1007/s00540-024-03334-4
PMID: 38493423
قاعدة البيانات: MEDLINE
الوصف
تدمد:1438-8359
DOI:10.1007/s00540-024-03334-4