دورية أكاديمية
Paraneoplastic autoimmune neurologic disorders associated with thymoma.
| العنوان: | Paraneoplastic autoimmune neurologic disorders associated with thymoma. |
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| المؤلفون: | Iorio R; Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: raffaele.iorio@policlinicogemelli.it., Lennon VA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States; Department of Neurology, Mayo Clinic, Rochester, MN, United States; Department of Immunology, Mayo Clinic, Rochester, MN, United States. |
| المصدر: | Handbook of clinical neurology [Handb Clin Neurol] 2024; Vol. 200, pp. 385-396. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0166161 Publication Model: Print Cited Medium: Internet ISSN: 0072-9752 (Print) Linking ISSN: 00729752 NLM ISO Abbreviation: Handb Clin Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1985- >: Amsterdam ; New York : Elsevier Original Publication: Amsterdam [Netherlands] : New York : North-Holland Pub. Co. ; Wiley Interscience Division - John Wiley & Sons, [©1969- |
| مواضيع طبية MeSH: | Thymoma*/complications , Thymoma*/diagnosis , Thymus Neoplasms*/complications , Thymus Neoplasms*/diagnosis , Nervous System Diseases*/complications , Isaacs Syndrome*, Humans ; Neoplasm Recurrence, Local ; Autoantibodies |
| مستخلص: | Thymoma is often associated with paraneoplastic neurologic diseases. Neural autoantibody testing is an important tool aiding diagnosis of thymoma and its autoimmune neurologic complications. Autoantibodies specific for muscle striational antigens and ion channels of the ligand-gated nicotinic acetylcholine receptor superfamily are the most prevalent biomarkers. The autoimmune neurologic disorders associating most commonly with thymoma are myasthenia gravis (MG), peripheral nerve hyperexcitability (neuromyotonia and Morvan syndrome), dysautonomia, and encephalitis. Patients presenting with these neurologic disorders should be screened for thymoma at diagnosis. Although they can cause profound disability, they usually respond to immunotherapy and treatment of the thymoma. Worsening of the neurologic disorder following surgical removal of a thymoma may herald tumor recurrence. Prompt recognition of paraneoplastic neurologic disorders is critical for patient management. A multidisciplinary approach is required for optimal management of neurologic autoimmunity associated with thymoma. (Copyright © 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.) |
| فهرسة مساهمة: | Keywords: Checkpoint inhibitor therapy; Immune-related adverse events; Nervous system; Neural autoantibodies; Neurologic autoimmunity; Neuromuscular junction; Thymus |
| المشرفين على المادة: | 0 (Autoantibodies) |
| تواريخ الأحداث: | Date Created: 20240317 Date Completed: 20240319 Latest Revision: 20240319 |
| رمز التحديث: | 20240319 |
| DOI: | 10.1016/B978-0-12-823912-4.00008-6 |
| PMID: | 38494291 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0072-9752 |
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| DOI: | 10.1016/B978-0-12-823912-4.00008-6 |