دورية أكاديمية
أعرض في EDS

Navigating the Cytokine Storm: A Comprehensive Review of Chemokines and Cytokines in Sepsis.

التفاصيل البيبلوغرافية
العنوان: Navigating the Cytokine Storm: A Comprehensive Review of Chemokines and Cytokines in Sepsis.
المؤلفون: Reddy H; Internal Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND., Javvaji CK; Pediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND., Malali S; Internal Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND., Kumar S; Internal Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND., Acharya S; Internal Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND., Toshniwal S; Internal Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
المصدر: Cureus [Cureus] 2024 Feb 15; Vol. 16 (2), pp. e54275. Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: This comprehensive review thoroughly explores the intricate relationship between chemokines, cytokines, and the cytokine storm in sepsis, offering a nuanced understanding of the molecular mechanisms underpinning this life-threatening syndrome. Beginning with examining sepsis stages and immune response dynamics, the review emphasizes the dysregulation leading to the cytokine storm, where pro- and anti-inflammatory cytokines disrupt the delicate immune equilibrium. Delving into chemokines, the discussion encompasses subfamilies, receptors, and functions, highlighting their critical roles in immune cell migration and activation during sepsis. The implications for clinical practice are substantial, suggesting avenues for targeted diagnostics and therapeutic interventions. The review identifies areas for future research, including the search for novel biomarkers, deeper insights into cytokine regulation, and the pursuit of personalized medicine approaches. This comprehensive exploration aims to guide clinicians, researchers, and policymakers in navigating the complexities of sepsis, fostering a foundation for transformative advancements in understanding and managing this formidable clinical challenge.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2024, Reddy et al.)
References: J Clin Invest. 1995 Jul;96(1):60-8. (PMID: 7542286)
Int J Mol Sci. 2021 Nov 30;22(23):. (PMID: 34884813)
Infect Chemother. 2014 Mar;46(1):1-12. (PMID: 24693464)
Cell Death Dis. 2020 Jul 15;11(7):535. (PMID: 32669536)
N Engl J Med. 2020 Dec 3;383(23):2255-2273. (PMID: 33264547)
Mediators Inflamm. 2013;2013:165974. (PMID: 23853427)
Lancet Infect Dis. 2019 Dec;19(12):e422-e436. (PMID: 31630991)
Annu Rev Pathol. 2011;6:19-48. (PMID: 20887193)
Eur J Intern Med. 2024 Mar;121:9-16. (PMID: 37919123)
Front Cell Infect Microbiol. 2022 Jun 23;12:901433. (PMID: 35811678)
Front Immunol. 2018 Sep 05;9:1926. (PMID: 30233566)
J Clin Med. 2023 Apr 15;12(8):. (PMID: 37109229)
Int J Mol Sci. 2022 Oct 03;23(19):. (PMID: 36233040)
MedComm (2020). 2022 Jun 08;3(2):e147. (PMID: 35702353)
J Dent Res. 2012 Jul;91(7):651-8. (PMID: 22302144)
Nat Methods. 2021 Oct;18(10):1181-1191. (PMID: 34594031)
Mol Immunol. 2002 Jan;38(8):567-80. (PMID: 11792425)
Neuro Oncol. 2005 Apr;7(2):122-33. (PMID: 15831231)
Med Intensiva. 2013 Nov;37(8):510-8. (PMID: 23158870)
Lancet Microbe. 2023 Jun;4(6):e431-e441. (PMID: 37116517)
Semin Immunopathol. 2017 Jul;39(5):517-528. (PMID: 28555385)
Annu Rev Immunol. 1988;6:439-64. (PMID: 3132954)
Trends Mol Med. 2014 Apr;20(4):224-33. (PMID: 24485901)
J Interferon Cytokine Res. 2014 Apr;34(4):215-9. (PMID: 24552151)
Br J Pharmacol. 2009 Aug;157(8):1318-29. (PMID: 19681864)
Intensive Care Med. 2000;26 Suppl 1:S124-8. (PMID: 10786969)
Int Anesthesiol Clin. 2007 Spring;45(2):27-37. (PMID: 17426506)
FEBS J. 2018 Aug;285(16):2944-2971. (PMID: 29637711)
Front Med (Lausanne). 2021 May 14;8:628302. (PMID: 34055825)
Virulence. 2014 Jan 1;5(1):36-44. (PMID: 23774844)
Nat Immunol. 2008 Apr;9(4):353-9. (PMID: 18349815)
Immunology. 2011 Nov;134(3):246-56. (PMID: 21977995)
فهرسة مساهمة: Keywords: biomarkers; chemokines; cytokine storm; immune response; sepsis; therapeutic interventions
تواريخ الأحداث: Date Created: 20240318 Latest Revision: 20240319
رمز التحديث: 20240319
مُعرف محوري في PubMed: PMC10944554
DOI: 10.7759/cureus.54275
PMID: 38496165
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.54275