دورية أكاديمية

Comparison of bolus versus continuous thermodilution derived indices of microvascular dysfunction in revascularized coronary syndromes.

التفاصيل البيبلوغرافية
العنوان: Comparison of bolus versus continuous thermodilution derived indices of microvascular dysfunction in revascularized coronary syndromes.
المؤلفون: Fawaz S; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom.; Department of Circulatory Health Research, Anglia Ruskin University, Chelmsford, CM1 1SQ, United Kingdom., Marin F; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, U.K.; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, U.K., Khan SA; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom.; Department of Circulatory Health Research, Anglia Ruskin University, Chelmsford, CM1 1SQ, United Kingdom., F G Simpson R; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom.; Department of Circulatory Health Research, Anglia Ruskin University, Chelmsford, CM1 1SQ, United Kingdom., Kotronias RA; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, U.K.; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, U.K., Chai J; Attikon University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, U.K., Acute Myocardial Infarction OxAMI Study Investigators O; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, U.K.; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, U.K., Al-Janabi F; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom., Jagathesan R; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom., Konstantinou K; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom., Mohdnazri SR; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom., Clesham GJ; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom.; Department of Circulatory Health Research, Anglia Ruskin University, Chelmsford, CM1 1SQ, United Kingdom., Tang KH; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom., Cook CM; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom.; Department of Circulatory Health Research, Anglia Ruskin University, Chelmsford, CM1 1SQ, United Kingdom., Channon KM; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, U.K.; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, U.K., Banning AP; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, U.K.; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, U.K., Davies JR; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom.; Department of Circulatory Health Research, Anglia Ruskin University, Chelmsford, CM1 1SQ, United Kingdom., Karamasis GV; Attikon University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., De Maria GL; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, U.K.; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, U.K., Keeble TR; Essex Cardiothoracic Centre, Mid and South Essex NHS Hospitals Trust, Basildon, SS16 5NL, United Kingdom.; Department of Circulatory Health Research, Anglia Ruskin University, Chelmsford, CM1 1SQ, United Kingdom.
المصدر: International journal of cardiology. Heart & vasculature [Int J Cardiol Heart Vasc] 2024 Mar 08; Vol. 51, pp. 101374. Date of Electronic Publication: 2024 Mar 08 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ireland Ltd Country of Publication: Ireland NLM ID: 101649525 Publication Model: eCollection Cited Medium: Print ISSN: 2352-9067 (Print) Linking ISSN: 23529067 NLM ISO Abbreviation: Int J Cardiol Heart Vasc Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Shannon [Ireland] : Elsevier Ireland Ltd., [2014]-
مستخلص: Background: The assessment of coronary microvascular dysfunction (CMD) using invasive methods is a field of growing interest, however the preferred method remains debated. Bolus and continuous thermodilution are commonly used methods, but weak agreement has been observed in patients with angina with non-obstructive coronary arteries (ANOCA). This study examined their agreement in revascularized acute coronary syndromes (ACS) and chronic coronary syndromes (CCS) patients.
Objective: To compare bolus thermodilution and continuous thermodilution indices of CMD in revascularized ACS and CCS patients and assess their diagnostic agreement at pre-defined cut-off points.
Methods: Patients from two centers underwent paired bolus and continuous thermodilution assessments after revascularization. CMD indices were compared between the two methods and their agreements at binary cut-off points were assessed.
Results: Ninety-six patients and 116 vessels were included. The mean age was 64 ± 11 years, and 20 (21 %) were female. Overall, weak correlations were observed between the Index of Microcirculatory Resistance (IMR) and continuous thermodilution microvascular resistance (R µ ) (rho = 0.30p = 0.001). The median coronary flow reserve (CFR) from continuous thermodilution (CFR cont ) and bolus thermodilution (CFR bolus ) were 2.19 (1.76-2.67) and 2.55 (1.50-3.58), respectively (p < 0.001). Weak correlation and agreement were observed between CFR cont and CFR bolus (rho = 0.37, p < 0.001, ICC 0.228 [0.055-0.389]). When assessed at CFR cut-off values of 2.0 and 2.5, the methods disagreed in 41 (35 %) and 45 (39 %) of cases, respectively.
Conclusions: There is a significant difference and weak agreement between bolus and continuous thermodilution-derived indices, which must be considered when diagnosing CMD in ACS and CCS patients.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Author(s).)
فهرسة مساهمة: Keywords: Bolus; Continuous; Coronary; Microvascular; Thermodilution
تواريخ الأحداث: Date Created: 20240318 Latest Revision: 20240508
رمز التحديث: 20240509
مُعرف محوري في PubMed: PMC10940925
DOI: 10.1016/j.ijcha.2024.101374
PMID: 38496256
قاعدة البيانات: MEDLINE
الوصف
تدمد:2352-9067
DOI:10.1016/j.ijcha.2024.101374