Exposure to HIV alters the composition of maternal microchimeric T cells in infants.

التفاصيل البيبلوغرافية
العنوان: Exposure to HIV alters the composition of maternal microchimeric T cells in infants.
المؤلفون: Armistead B; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA., Peters MQ; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA., Houck J; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA., Carlson M; Research Scientific Computing, Enterprise Analytics, Seattle Children's Research Institute, Seattle, Washington, USA., Balle C; Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Mulugeta N; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA., Gray CM; Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Division of Immunology, Biomedical Research Institute, Stellenbosch University, Cape Town, South Africa., Jaspan HB; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Pediatrics, University of Washington, Seattle, Washington, USA., Harrington WE; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 04. Date of Electronic Publication: 2024 Mar 04.
نوع المنشور: Preprint
اللغة: English
بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
مستخلص: Infants exposed to HIV but uninfected (iHEU) display altered cellular immunity and are at increased risk of infection through poorly understood mechanisms. We previously reported that iHEU have lower levels of maternal microchimerism (MMc), maternal cells transferred to the offspring in utero/during breastfeeding. We evaluated MMc levels in T cell subsets in iHEU and HIV unexposed infants (iHU) to determine whether a selective deficiency in MMc may contribute to altered cellular immunity. Across all infants, MMc levels were highest in CD8+ T cells; however, the level of MMc in the CD8 T cell subset was significantly lower in iHEU compared to iHU.
Competing Interests: The authors declare no conflicts of interest.
معلومات مُعتمدة: T32 AI007509 United States AI NIAID NIH HHS; K08 AI135072 United States AI NIAID NIH HHS; R01 AI120714 United States AI NIAID NIH HHS; R21 AI157821 United States AI NIAID NIH HHS; U01 AI131302 United States AI NIAID NIH HHS; T32 HD007233 United States HD NICHD NIH HHS
تواريخ الأحداث: Date Created: 20240318 Latest Revision: 20240325
رمز التحديث: 20240325
مُعرف محوري في PubMed: PMC10942331
DOI: 10.1101/2024.03.01.583002
PMID: 38496450
قاعدة البيانات: MEDLINE
الوصف
DOI:10.1101/2024.03.01.583002