دورية أكاديمية
CASM mediates LRRK2 recruitment and activation under lysosomal stress.
| العنوان: | CASM mediates LRRK2 recruitment and activation under lysosomal stress. |
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| المؤلفون: | Kuwahara T; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Iwatsubo T; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. |
| المصدر: | Autophagy [Autophagy] 2024 Jul; Vol. 20 (7), pp. 1692-1693. Date of Electronic Publication: 2024 Mar 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Georgetown, TX : Landes Bioscience, 2005- |
| مواضيع طبية MeSH: | Lysosomes*/metabolism , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/metabolism , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics, Humans ; Animals ; Stress, Physiological ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Parkinson Disease/genetics |
| مستخلص: | Conjugation of ATG8 to single membranes (CASM) at endolysosomal compartments has attracted attention as the non-autophagic function of the Atg8-family protein conjugation system, and the V-ATPase-ATG16L1 axis has emerged as a core mechanism. Our recent research has revealed that this mechanism contributes to the lysosomal recruitment and activation of LRRK2, a Parkinson disease-associated kinase that phosphorylates a subset of RAB GTPases. The activated LRRK2 under CASM-causing lysosomal stress acts to regulate lysosomal morphology and stimulate extracellular secretion of lysosomal contents, thereby promoting the lysosomal stress response. |
| فهرسة مساهمة: | Keywords: ATG8 conjugation system; CASM; LAP; LRRK2; V-ATPase-ATG16L1 axis; lysosome |
| المشرفين على المادة: | EC 2.7.11.1 (Leucine-Rich Repeat Serine-Threonine Protein Kinase-2) EC 2.7.11.1 (LRRK2 protein, human) |
| تواريخ الأحداث: | Date Created: 20240318 Date Completed: 20240626 Latest Revision: 20240626 |
| رمز التحديث: | 20240626 |
| DOI: | 10.1080/15548627.2024.2330032 |
| PMID: | 38497477 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1554-8635 |
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| DOI: | 10.1080/15548627.2024.2330032 |