دورية أكاديمية
أعرض في EDS

Impact of Secondary Amenorrhea on Cardiovascular Disease Risk in Physically Active Women: A Systematic Review and Meta-Analysis.

التفاصيل البيبلوغرافية
العنوان: Impact of Secondary Amenorrhea on Cardiovascular Disease Risk in Physically Active Women: A Systematic Review and Meta-Analysis.
المؤلفون: Tegg NL; Faculty of Nursing University of Alberta Edmonton Alberta Canada., Myburgh C; Faculty of Nursing University of Alberta Edmonton Alberta Canada.; Faculty of Natural Sciences The Kings University Edmonton Alberta Canada., O'Donnell E; Loughborough University Leicestershire United Kingdom., Kennedy M; University of Alberta Library Edmonton Alberta Canada., Norris CM; Faculty of Nursing University of Alberta Edmonton Alberta Canada.; Cavarzan Chair in Mature Women's Research, WCHRI Edmonton Alberta Canada.; Faculty of Medicine, School of Public Health Sciences University of Alberta Edmonton Alberta Canada.
المصدر: Journal of the American Heart Association [J Am Heart Assoc] 2024 Mar 19; Vol. 13 (6), pp. e033154. Date of Electronic Publication: 2024 Mar 18.
نوع المنشور: Meta-Analysis; Systematic Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc
أسماء مطبوعة: Original Publication: Oxford : Wiley-Blackwell
مواضيع طبية MeSH: Amenorrhea*/physiopathology , Amenorrhea*/blood , Amenorrhea*/epidemiology , Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/etiology , Cardiovascular Diseases*/physiopathology , Exercise*/physiology , Heart Disease Risk Factors*, Humans ; Female ; Risk Assessment ; Adult ; Young Adult ; Risk Factors ; Adolescent
مستخلص: Background: Exercise-associated secondary amenorrhea results in estrogen deficiency, which may lead to dysfunction in estrogen's normal cardioprotective pathways. Estrogen may be essential in a woman's endothelial adaptations to exercise. The objective of this review was to assess the association between secondary amenorrhea in physically active women and cardiovascular disease (CVD) risk.
Methods and Results: A literature search was performed in January 2023 and updated in August 2023 of the Cumulative Index to Nursing and Allied Health Literature (EBSCOhost), Cochrane Library, Embase (Ovid), MEDLINE (Ovid), SPORTDiscus (EBSCOhost), and Scopus from inception to present with no date or language limitations. Citation chaining was done to screen for additional studies. Eight sources were searched for gray literature. Studies that compared physically active women with amenorrhea to physically active women with eumenorrhea aged 18 to 35 years with evidence of CVD, alterations to cardiovascular physiology, or CVD risks were included. Eighteen observational studies from 3 countries were included. Overall, the quality of evidence was good. A meta-analysis was performed. Physically active women with secondary amenorrhea had significantly lower estradiol, flow-mediated dilation, resting heart rate, systolic blood pressure, and diastolic blood pressure and higher total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein cholesterol.
Conclusions: Estrogen deficiency resulting from exercise-associated secondary amenorrhea in physically active women may impact cardiovascular physiology and certain CVD risk factors. The research in this area is observational; therefore, findings should be interpreted cautiously. However, as exercise-associated secondary amenorrhea is reversible and the primary prevention of CVD is important for public health, it may be important to treat secondary amenorrhea and restore estrogen levels.
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فهرسة مساهمة: Keywords: amenorrhea; cardiovascular disease; endothelial function; exercise; women
تواريخ الأحداث: Date Created: 20240318 Date Completed: 20240807 Latest Revision: 20240807
رمز التحديث: 20240808
مُعرف محوري في PubMed: PMC11010010
DOI: 10.1161/JAHA.123.033154
PMID: 38497482
قاعدة البيانات: MEDLINE
الوصف
تدمد:2047-9980
DOI:10.1161/JAHA.123.033154