دورية أكاديمية
Brain Autopsy Findings in a Patient Who Received Lipid Emulsion Therapy for Suspected Drug Intoxication.
العنوان: | Brain Autopsy Findings in a Patient Who Received Lipid Emulsion Therapy for Suspected Drug Intoxication. |
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المؤلفون: | Cutshall H; From the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Gokden M |
المصدر: | The American journal of forensic medicine and pathology [Am J Forensic Med Pathol] 2024 Mar 18. Date of Electronic Publication: 2024 Mar 18. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8108948 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-404X (Electronic) Linking ISSN: 01957910 NLM ISO Abbreviation: Am J Forensic Med Pathol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2002- > : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York : Masson Publishing USA. |
مستخلص: | Abstract: Lipid emulsion therapy (LET) is the intravenous administration of lipid solution for parenteral alimentation, especially in preterm infants and adults with debilitating illnesses. It has also been used in attempts of detoxification in suspected cases of drug overdose. Whether this interferes with circulation and/or perfusion is debatable, and it is suggested that it may interfere with coagulation process. The emulsifying agent has been identified microscopically mainly in the lungs of these patients, with rare reports in adults and even more rare ones in the brain; however, although it is rarely reported in other organs, to our knowledge, no reports of gross autopsy findings in the brain are available in the English literature, nor are there reports of pathologic findings after lipid emulsion therapy administration for drug toxicity. Although it is also debated in the literature whether this material forms as an artifact or represents the actual agent, here we report the gross and microscopic autopsy findings in the brain of a patient who received LET for suspected beta-blocker intoxication. It will be beneficial for pathologists who perform autopsies in the forensic or medical settings to be aware of these findings, along with the uses and potential complications of LET. Competing Interests: Conflict of Interest: None of the authors have any conflict of interest to report regarding this work. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
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تواريخ الأحداث: | Date Created: 20240318 Latest Revision: 20240318 |
رمز التحديث: | 20240318 |
DOI: | 10.1097/PAF.0000000000000933 |
PMID: | 38497659 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1533-404X |
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DOI: | 10.1097/PAF.0000000000000933 |