دورية أكاديمية
أعرض في EDS

Brain Autopsy Findings in a Patient Who Received Lipid Emulsion Therapy for Suspected Drug Intoxication.

التفاصيل البيبلوغرافية
العنوان: Brain Autopsy Findings in a Patient Who Received Lipid Emulsion Therapy for Suspected Drug Intoxication.
المؤلفون: Cutshall H; From the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Gokden M
المصدر: The American journal of forensic medicine and pathology [Am J Forensic Med Pathol] 2024 Mar 18. Date of Electronic Publication: 2024 Mar 18.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8108948 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-404X (Electronic) Linking ISSN: 01957910 NLM ISO Abbreviation: Am J Forensic Med Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2002- > : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York : Masson Publishing USA.
مستخلص: Abstract: Lipid emulsion therapy (LET) is the intravenous administration of lipid solution for parenteral alimentation, especially in preterm infants and adults with debilitating illnesses. It has also been used in attempts of detoxification in suspected cases of drug overdose. Whether this interferes with circulation and/or perfusion is debatable, and it is suggested that it may interfere with coagulation process. The emulsifying agent has been identified microscopically mainly in the lungs of these patients, with rare reports in adults and even more rare ones in the brain; however, although it is rarely reported in other organs, to our knowledge, no reports of gross autopsy findings in the brain are available in the English literature, nor are there reports of pathologic findings after lipid emulsion therapy administration for drug toxicity. Although it is also debated in the literature whether this material forms as an artifact or represents the actual agent, here we report the gross and microscopic autopsy findings in the brain of a patient who received LET for suspected beta-blocker intoxication. It will be beneficial for pathologists who perform autopsies in the forensic or medical settings to be aware of these findings, along with the uses and potential complications of LET.
Competing Interests: Conflict of Interest: None of the authors have any conflict of interest to report regarding this work.
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
References: Holt LE, Tidwell HC, Scott TFM. The intravenous administration of fat. J Pediatr. 1935;25:151–160.
Liu Y, Zhang J, Yu P, et al. Mechanisms and efficacy of intravenous lipid emulsion treatment for systemic toxicity from local anesthetics. Front Med (Lausanne). 2021;8:756866.
Rothschild L, Bern S, Oswald S, et al. Intravenous lipid emulsion in clinical toxicology. Scand J Trauma Resusc Emerg Med. 2010;18:51.
Schulz PE, Weiner SP, Haber LM, et al. Neurological complications from fat emulsion therapy. Ann Neurol. 1994;35:628–630.
Weinberg GL, Riou B. Lipid emulsion infusion. Resuscitation for local anesthetic and other drug overdose. Anesthesiology. 2012;117:180–187.
Barson AJ, Chiswick ML, Doig CM. Fat embolism in infancy after intravenous fat infusions. Arch Dis Child. 1978;53:218–223.
Levene MI, Wigglesworth JS, Desai R. Pulmonary fat accumulation after intralipid infusion in the preterm infant. Lancet. 1980;2:815–818.
Shulman RJ, Langston C, Schanler RJ. Pulmonary vascular lipid deposition after administration of intravenous fat to infants. Pediatrics. 1987;79:99–102.
Puntis JW, Rushton DI. Pulmonary intravascular lipid in neonatal necropsy specimens. Arch Dis Child. 1991;66:26–28.
Haber LM, Hawkins EP, Seilheimer DK, et al. Fat overload syndrome. An autopsy study with evaluation of the coagulopathy. Am J Clin Pathol. 1988;90:223–227.
Freund U, Krausz Y, Levij IS, et al. Latrogenic lipidosis following prolonged intravenous hyperalimentation. Am J Clin Nutr. 1975;28:1156–1160.
Hessov I, Melsen F, Haug A. Postmortem findings in three patients treated with intravenous fat emulsions. Arch Surg. 1979;114:66–68.
Schröder H, Paust H, Schmidt R. Pulmonary fat embolism after intralipid therapy – a post-mortem artefact? Light and electron microscopic investigations in low-birth-weight infants. Acta Paediatr Scand. 1984;73:461–464.
Belin RP, Bivins BA, Jona JZ, et al. Fat overload with a 10% soybean oil emulsion. Arch Surg. 1976;111:1391–1393.
Heyman MB, Storch S, Ament ME. The fat overload syndrome. Report of a case and literature review. Am J Dis Child. 1981;135:628–630.
Burnham WR, Heptinstall S, Cockbill SR, et al. Blood platelet behaviour during infusion of an Intralipid-based intravenous feeding mixture. Postgrad Med J. 1982;58:152–155.
Hulman G, Fraser I, Pearson HJ, et al. Agglutination of intralipid by sera of acutely ill patients. Lancet. 1982;2:1426–1427.
Campbell AN, Freedman MH, Pencharz PB, et al. Bleeding disorder from the “fat overload” syndrome. JPEN J Parenter Enteral Nutr. 1984;8:447–449.
Buckenmaier CC 3rd, Capacchione J, Mileke AR, et al. The effect of lipid emulsion infusion on postmortem ropivacaine concentrations in swine: endeavoring to comprehend a soldier's death. Anesth Analg. 2012;114:894–900.
Food and Drug Administration, Intralipid® access data. Available at: https://www.accessdata.fda.gov/drugsatfda&#95;docs/label/2018/017643s078,018449s045,019942s016,020248s022lbl.pdf Accessed on Nov. 24th., 2023.
تواريخ الأحداث: Date Created: 20240318 Latest Revision: 20240318
رمز التحديث: 20240318
DOI: 10.1097/PAF.0000000000000933
PMID: 38497659
قاعدة البيانات: MEDLINE
الوصف
تدمد:1533-404X
DOI:10.1097/PAF.0000000000000933