دورية أكاديمية
Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer.
| العنوان: | Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer. |
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| المؤلفون: | Zhu Z; Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China., Peng Q; Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, People's Republic of China., Duan X; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China, Chengdu, People's Republic of. China., Li J; School of Medicine, Southwest Medical University of China, Luzhou, People's Republic of China.; Department of Radiotherapy, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, People's Republic of China. |
| المصدر: | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2024 Apr; Vol. 44 (4), pp. 158-169. Date of Electronic Publication: 2024 Mar 18. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 9507088 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7465 (Electronic) Linking ISSN: 10799907 NLM ISO Abbreviation: J Interferon Cytokine Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: New York, NY : Mary Ann Liebert, c1995- |
| مواضيع طبية MeSH: | Colorectal Neoplasms*/therapy , Interleukin-12*/immunology , Interleukin-12*/therapeutic use, Humans ; Cytokines ; Interleukin-12 Subunit p35 ; Interleukin-12 Subunit p40 ; Interleukin-23 |
| مستخلص: | Interleukin 12 (IL-12) is a heterodimer consisting of 2 subunits, p35 and p40, with unique associations and interacting functions with its family members. IL-12 is one of the most important cytokines regulating the immune system response and is integral to adaptive immunity. IL-12 has shown marked therapeutic potential in a variety of tumor types. This review therefore summarizes the characteristics of IL-12 and its application in tumor treatment, focusing on its antitumor effects in colorectal cancer (CRC) and potential radiosensitization mechanisms. We aim to provide a current reference for IL-12 and other potential CRC treatment strategies. |
| فهرسة مساهمة: | Keywords: IL-12; antitumor therapy; colorectal cancer; immunotherapy |
| المشرفين على المادة: | 0 (Cytokines) 187348-17-0 (Interleukin-12) 0 (Interleukin-12 Subunit p35) 0 (Interleukin-12 Subunit p40) 0 (Interleukin-23) |
| تواريخ الأحداث: | Date Created: 20240318 Date Completed: 20240408 Latest Revision: 20240411 |
| رمز التحديث: | 20240412 |
| DOI: | 10.1089/jir.2023.0190 |
| PMID: | 38498032 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-7465 |
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| DOI: | 10.1089/jir.2023.0190 |