دورية أكاديمية
Design, Synthesis, and Fungicidal Activities of Novel N -(Pyrazol-5-yl)benzamide Derivatives Containing a Diphenylamine Moiety.
| العنوان: | Design, Synthesis, and Fungicidal Activities of Novel N -(Pyrazol-5-yl)benzamide Derivatives Containing a Diphenylamine Moiety. |
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| المؤلفون: | Ma YD; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.; Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China., Zhou H; Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China., Lin GT; Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China., Wu KH; Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China., Xu G; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.; Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.; State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling, Shaanxi 712100, People's Republic of China., Liu X; Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.; State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling, Shaanxi 712100, People's Republic of China., Xu D; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.; Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.; State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling, Shaanxi 712100, People's Republic of China. |
| المصدر: | Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Mar 27; Vol. 72 (12), pp. 6691-6701. Date of Electronic Publication: 2024 Mar 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Antifungal Agents*/pharmacology , Fungicides, Industrial*/chemistry , Strobilurins* , Acetates* , Amides* , Imines*, Structure-Activity Relationship ; Diphenylamine/chemistry ; Molecular Docking Simulation ; Benzamides ; Succinate Dehydrogenase |
| مستخلص: | To accelerate the development of novel fungicides, a variety of N -(pyrazol-5-yl)benzamide derivatives with a diphenylamine moiety were designed and synthesized using a pharmacophore recombination strategy based on the structure of pyrazol-5-yl-aminophenyl-benzamides. The bioassay results demonstrated that most of the target compounds had excellent in vitro antifungal activities against Sclerotinia sclerotiorum , Valsa mali , and Botrytis cinerea . In particular, compound 5IIIh exhibited remarkable activity against S. sclerotiorum (EC |
| فهرسة مساهمة: | Keywords: N-(pyrazol-5-yl)benzamide; diphenylamine; fungicidal activity; molecular docking; structure−activity relationships; succinate dehydrogenase inhibitor |
| المشرفين على المادة: | 0 (Antifungal Agents) F625Z36B2D (trifloxystrobin) 7U8P4NAR2S (fluxapyroxad) 9N3CBB0BIQ (Diphenylamine) 6X80438640 (benzamide) 0 (Fungicides, Industrial) 0 (Benzamides) EC 1.3.99.1 (Succinate Dehydrogenase) 0 (Strobilurins) 0 (Acetates) 0 (Amides) 0 (Imines) |
| تواريخ الأحداث: | Date Created: 20240318 Date Completed: 20240328 Latest Revision: 20240328 |
| رمز التحديث: | 20240329 |
| DOI: | 10.1021/acs.jafc.3c07567 |
| PMID: | 38498985 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5118 |
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| DOI: | 10.1021/acs.jafc.3c07567 |