دورية أكاديمية
أعرض في EDS

Natural and hybrid immunity after SARS-CoV-2 infection in children and adolescents.

التفاصيل البيبلوغرافية
العنوان: Natural and hybrid immunity after SARS-CoV-2 infection in children and adolescents.
المؤلفون: Rothoeft T; University Hospital of Pediatrics and Adolescent Medicine, St. Josef-Hospital, Ruhr-University, Bochum, Germany. tobias.rothoeft@rub.de., Maier C; University Hospital of Pediatrics and Adolescent Medicine, St. Josef-Hospital, Ruhr-University, Bochum, Germany., Talarico A; University Hospital of Pediatrics and Adolescent Medicine, St. Josef-Hospital, Ruhr-University, Bochum, Germany., Hoffmann A; University Hospital of Pediatrics and Adolescent Medicine, St. Josef-Hospital, Ruhr-University, Bochum, Germany., Schlegtendal A; University Hospital of Pediatrics and Adolescent Medicine, St. Josef-Hospital, Ruhr-University, Bochum, Germany., Lange B; Department of Epidemiology, Helmholtz Centre for Infection Research, Brunswick, Germany., Petersmann A; University Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Oldenburg, Oldenburg, Germany.; University Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Denz R; Department of Medical Informatics, Biometry and Epidemiology, Ruhr-University Bochum, Bochum, Germany., Timmesfeld N; Department of Medical Informatics, Biometry and Epidemiology, Ruhr-University Bochum, Bochum, Germany., Toepfner N; Department of Pediatrics, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Vidal-Blanco E; Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Pfaender S; Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Lücke T; University Hospital of Pediatrics and Adolescent Medicine, St. Josef-Hospital, Ruhr-University, Bochum, Germany., Brinkmann F; University Hospital of Pediatrics and Adolescent Medicine, St. Josef-Hospital, Ruhr-University, Bochum, Germany.; University Children's Hospital, Lübeck, Germany.; Airway Research Center North (ARCN), German Center for Lung Research (DZL), Lübeck, Germany.
المصدر: Infection [Infection] 2024 Aug; Vol. 52 (4), pp. 1449-1458. Date of Electronic Publication: 2024 Mar 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Heidelberg Country of Publication: Germany NLM ID: 0365307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0973 (Electronic) Linking ISSN: 03008126 NLM ISO Abbreviation: Infection Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : Heidelberg : Springer Heidelberg
Original Publication: München, Verlagsgesellschaft Otto Spatz.
مواضيع طبية MeSH: COVID-19*/immunology , Antibodies, Neutralizing*/blood , Antibodies, Neutralizing*/immunology , Antibodies, Viral*/blood , SARS-CoV-2*/immunology , Spike Glycoprotein, Coronavirus*/immunology , Immunity, Humoral* , Immunity, Cellular*, Humans ; Adolescent ; Child ; Male ; Female ; Child, Preschool ; COVID-19 Vaccines/immunology ; Immunity, Innate ; Coronavirus Nucleocapsid Proteins/immunology
مستخلص: Purpose: In contrast to adults, immune protection against SARS-CoV-2 in children and adolescents with natural or hybrid immunity is still poorly understood. The aim of this study was to analyze different immune compartments in different age groups and whether humoral immune reactions correlate with a cellular immune response.
Methods: 72 children and adolescents with a preceding SARS-CoV-2 infection were recruited. 37 were vaccinated with an RNA vaccine (BNT162b2). Humoral immunity was analyzed 3-26 months (median 10 months) after infection by measuring Spike protein (S), nucleocapsid (NCP), and neutralizing antibodies (nAB). Cellular immunity was analyzed using a SARS-CoV-2-specific interferon-γ release assay (IGRA).
Results: All children and adolescents had S antibodies; titers were higher in those with hybrid immunity (14,900 BAU/ml vs. 2118 BAU/ml). NCP antibodies were detectable in > 90%. Neutralizing antibodies (nAB) were more frequently detected (90%) with higher titers (1914 RLU) in adolescents with hybrid immunity than in children with natural immunity (62.5%, 476 RLU). Children with natural immunity were less likely to have reactive IGRAs (43.8%) than adolescents with hybrid immunity (85%). The amount of interferon-γ released by T cells was comparable in natural and hybrid immunity.
Conclusion: Spike antibodies are the most reliable markers to monitor an immune reaction against SARS-CoV-2. High antibody titers of spike antibodies and nAB correlated with cellular immunity, a phenomenon found only in adolescents with hybrid immunity. Hybrid immunity is associated with markedly higher antibody titers and a higher probability of a cellular immune response than a natural immunity.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 01KI20173 (Corkid) Bundesministerium für Bildung und Forschung; 01KX2121 (Immunebridge) Bundesministerium für Bildung und Forschung
فهرسة مساهمة: Keywords: Antibody; COVID-19; Children; Convalescent; Immunity; SARS-CoV-2; T cell; Vaccination
المشرفين على المادة: 0 (Antibodies, Neutralizing)
0 (Antibodies, Viral)
0 (Spike Glycoprotein, Coronavirus)
0 (spike protein, SARS-CoV-2)
0 (COVID-19 Vaccines)
0 (Coronavirus Nucleocapsid Proteins)
تواريخ الأحداث: Date Created: 20240319 Date Completed: 20240730 Latest Revision: 20240802
رمز التحديث: 20240802
مُعرف محوري في PubMed: PMC11288991
DOI: 10.1007/s15010-024-02225-w
PMID: 38499828
قاعدة البيانات: MEDLINE
الوصف
تدمد:1439-0973
DOI:10.1007/s15010-024-02225-w