دورية أكاديمية
أعرض في EDS

Time course changes in in vivo muscle mechanical function and Ca 2+ regulation of force following experimentally induced gradual ovarian failure in mice.

التفاصيل البيبلوغرافية
العنوان: Time course changes in in vivo muscle mechanical function and Ca 2+ regulation of force following experimentally induced gradual ovarian failure in mice.
المؤلفون: Hinks A; Department of Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada., Dalton BE; Department of Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada., Mashouri P; Department of Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada., Flewwelling LD; Muscle Health Research Centre, School of Kinesiology and Health Sciences, Faculty of Health, York University, Toronto, Canada., Pyle WG; IMPART Team Canada, Dalhousie Medicine, Dalhousie University, Saint John, New Brunswick, Canada., Cheng AJ; Muscle Health Research Centre, School of Kinesiology and Health Sciences, Faculty of Health, York University, Toronto, Canada., Power GA; Department of Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada.
المصدر: Experimental physiology [Exp Physiol] 2024 May; Vol. 109 (5), pp. 711-728. Date of Electronic Publication: 2024 Mar 18.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9002940 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-445X (Electronic) Linking ISSN: 09580670 NLM ISO Abbreviation: Exp Physiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, Eng : Wiley-Blackwell
Original Publication: Cambridge ; New York, NY, USA : Published for the Physiological Society by Cambridge University Press, c1990-
مواضيع طبية MeSH: Vinyl Compounds*/pharmacology , Muscle, Skeletal*/physiopathology , Muscle, Skeletal*/metabolism , Muscle Fatigue*/physiology , Muscle Contraction*/physiology , Calcium*/metabolism, Animals ; Female ; Mice ; Torque ; Mice, Inbred C57BL ; Cyclohexenes/pharmacology ; Isometric Contraction/physiology ; Primary Ovarian Insufficiency/physiopathology ; Primary Ovarian Insufficiency/metabolism
مستخلص: The abrupt cessation of ovarian hormone release is associated with declines in muscle contractile function, yet the impact of gradual ovarian failure on muscle contractility across peri-, early- and late-stage menopause remains unclear. In this study, a 4-vinylcyclohexene diepoxide (VCD)-induced ovarian failure mouse model was used to examine time course changes in muscle mechanical function. Plantar flexors of female mice (VCD: n = 10; CON: n = 8) were assessed at 40 (early perimenopause), 80 (late perimenopause), 120 (menopause onset) and 176 (late menopause) days post-initial VCD injection. A torque-frequency relationship was established across a range of frequencies (10-200 Hz). Isotonic dynamic contractions were elicited against relative loads (10-80% maximal isometric torque) to determine the torque-velocity-power relationship. Mice then performed a fatigue task using intermittent 100 Hz isometric contractions until torque dropped by 60%. Recovery of twitch, 10 Hz and 100 Hz torque were tracked for 10 min post-task failure. Additionally, intact muscle fibres from the flexor digitorum brevis underwent a fatigue task (50 repetitions at 70 Hz), and 10 and 100 Hz tetanic [Ca 2+ ] were monitored for 10 min afterward. VCD mice exhibited 16% lower twitch torque than controls across all time points. Apart from twitch torque, 10 Hz torque and 10 Hz tetanic [Ca 2+ ], where VCD showed greater values relative to pre-fatigue during recovery, no significant differences were observed between control and VCD mice during recovery. These results indicate that gradual ovarian failure has minimal detriments to in vivo muscle mechanical function, with minor alterations observed primarily for low-frequency stimulation during recovery from fatigue.
(© 2024 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.)
References: J Appl Physiol (1985). 2005 Feb;98(2):429-36. (PMID: 15475602)
J Musculoskelet Neuronal Interact. 2009 Oct-Dec;9(4):186-97. (PMID: 19949277)
Exp Gerontol. 2019 Jan;115:155-164. (PMID: 30415069)
Life Sci. 2020 Feb 1;242:117242. (PMID: 31891723)
Sports Med. 2010 Jan 1;40(1):41-58. (PMID: 20020786)
Toxicol Pathol. 2001 Jan-Feb;29(1):91-9. (PMID: 11215690)
Adv Exp Med Biol. 2010;682:315-42. (PMID: 20824534)
Clin Sci (Lond). 1993 Jan;84(1):95-8. (PMID: 8382141)
J Muscle Res Cell Motil. 2013 Dec;34(5-6):317-32. (PMID: 24162313)
Med Sci Sports Exerc. 2015 Jun;47(6):1177-87. (PMID: 25255128)
Sports Med. 2022 Dec;52(12):2853-2869. (PMID: 35907119)
Br J Sports Med. 2005 May;39(5):251-3. (PMID: 15849284)
Can J Physiol Pharmacol. 2003 Sep;81(9):873-9. (PMID: 14614523)
Am J Physiol. 1984 Nov;247(5 Pt 1):C462-71. (PMID: 6548609)
Acta Physiol (Oxf). 2019 Sep;227(1):e13290. (PMID: 31050200)
PLoS One. 2012;7(4):e35538. (PMID: 22514749)
Physiology (Bethesda). 2016 Jul;31(4):250-7. (PMID: 27252160)
Eur J Appl Physiol. 2004 Oct;93(1-2):130-8. (PMID: 15248071)
Am J Physiol. 1999 Aug;277(2):H467-73. (PMID: 10444470)
Acta Physiol (Oxf). 2006 Oct;188(2):113-21. (PMID: 16948798)
Physiol Genomics. 2022 Nov 1;54(11):417-432. (PMID: 36062884)
Int J Mol Sci. 2023 Jan 17;24(3):. (PMID: 36768177)
Proc R Soc Lond B Biol Sci. 1949 Jun 23;136(883):195-211. (PMID: 18152150)
J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1071-81. (PMID: 19561145)
Biol Reprod. 1973 May;8(4):491-4. (PMID: 4736343)
Med Sci Sports Exerc. 2012 Sep;44(9):1671-9. (PMID: 22460476)
Curr Protoc Mouse Biol. 2015 Mar 02;5(1):51-63. (PMID: 25727200)
Muscle Nerve. 2002 Nov;26(5):630-5. (PMID: 12402284)
J Appl Physiol (1985). 2005 May;98(5):1674-81. (PMID: 15649876)
Am J Physiol Cell Physiol. 2014 Dec 1;307(11):C1031-8. (PMID: 25252949)
J Gen Physiol. 1991 Sep;98(3):615-35. (PMID: 1761971)
Am J Physiol Endocrinol Metab. 2016 May 1;310(9):E724-33. (PMID: 26956186)
J Physiol. 2021 Sep;599(18):4337-4356. (PMID: 34368970)
Clin Sci (Lond). 2001 Aug;101(2):147-57. (PMID: 11473488)
J Appl Physiol (1985). 2018 Apr 1;124(4):980-992. (PMID: 29345963)
J Appl Physiol (1985). 2011 Jan;110(1):109-15. (PMID: 20966194)
Aviat Space Environ Med. 2010 Jul;81(7):632-8. (PMID: 20597241)
PLoS One. 2021 Mar 31;16(3):e0249472. (PMID: 33788896)
Maturitas. 2024 Feb;180:107885. (PMID: 38061310)
Mol Ther Methods Clin Dev. 2021 Mar 03;21:144-160. (PMID: 33850950)
Int J Sports Med. 2017 Dec;38(14):1097-1104. (PMID: 29126339)
J Appl Physiol (1985). 2007 Apr;102(4):1387-93. (PMID: 17218423)
J Br Menopause Soc. 2005 Jun;11(2):45-50. (PMID: 15970014)
Toxicol Appl Pharmacol. 1996 Aug;139(2):394-401. (PMID: 8806857)
Biol Reprod. 2004 Jul;71(1):130-8. (PMID: 14998904)
Skelet Muscle. 2019 Jan 24;9(1):4. (PMID: 30678732)
Acta Neurol Scand. 1976 Jul;54(1):45-56. (PMID: 132838)
Am J Physiol Cell Physiol. 2023 Oct 1;325(4):C1031-C1045. (PMID: 37661923)
J Struct Biol. 1999 Aug;127(1):1-15. (PMID: 10479612)
Int J Biochem Cell Biol. 2005 Jul;37(7):1344-9. (PMID: 15833266)
J Vis Exp. 2019 Jan 17;(143):. (PMID: 30735157)
Eur J Appl Physiol. 2016 Jun;116(6):1091-116. (PMID: 26941023)
J Appl Physiol (1985). 2006 Feb;100(2):548-59. (PMID: 16254070)
Biol Reprod. 2011 Oct;85(4):755-62. (PMID: 21677306)
Exp Physiol. 2024 May;109(5):711-728. (PMID: 38500268)
معلومات مُعتمدة: RGPIN-2017-06012 Natural Sciences and Engineering Research Council of Canada (NSERC)
فهرسة مساهمة: Keywords: VCD; menopause; muscle; ovarian hormones; ovaries; perimenopause; power
المشرفين على المادة: 0 (Vinyl Compounds)
596C064IG4 (4-vinyl-1-cyclohexene dioxide)
SY7Q814VUP (Calcium)
0 (Cyclohexenes)
تواريخ الأحداث: Date Created: 20240319 Date Completed: 20240501 Latest Revision: 20240503
رمز التحديث: 20240503
مُعرف محوري في PubMed: PMC11061627
DOI: 10.1113/EP091735
PMID: 38500268
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-445X
DOI:10.1113/EP091735