دورية أكاديمية
أعرض في EDS

Hearing loss in beta-thalassaemia: An Italian multicentre case-control study.

التفاصيل البيبلوغرافية
العنوان: Hearing loss in beta-thalassaemia: An Italian multicentre case-control study.
المؤلفون: Manara R; Neuroradiology, Neurosciences Department, University of Padova, Padova, Italy.; DIMED, University of Padova, Padova, Italy., Brotto D; Section of Otorhinolaryngology, Neurosciences Department, University of Padova, Padova, Italy., Barillari MR; Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Costa G; Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Villani AV; Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania 'Luigi Vanvitelli', Napoli, Italy., Perna C; Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania 'Luigi Vanvitelli', Napoli, Italy., Ziello B; UOSD Malattie Rare del Globulo Rosso, Dipartimento di oncoematologia e pneumologia, AORN Cardarelli, Naples, Italy., di Salle F; Dipartimento di Medicina e Chirurgia, Scuola Medica Salernitana, Università di Salerno, Fisciano, Italy., Cantone E; Department of Neurosciences, Reproductive and Odontostomatologic Sciences, Unit of Ear, Nose and Throat, 'Federico II' University, Naples, Italy., Pasanisi A; Centro della Microcitemia 'A. Quarta' UOC di Ematologia con trapiannto Ospedale Perrino, Brindisi, Italy., De Michele E; Medicina Trasfusionale AUO 'San Giovanni di Dio e Ruggi D'Aragona', Salerno, Italy., Ciancio A; Unità Operativa Ematologia-Day Hospital di Talassemia, Ospedale 'Madonna delle Grazie', Matera, Italy., D'Urzo G; Dipartimento di Pediatria, Ospedale 'Umberto I', Nocera Inferiore, Italy., Valentino P; Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania 'Luigi Vanvitelli', Napoli, Italy., Perrotta S; Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania 'Luigi Vanvitelli', Napoli, Italy., Ricchi P; UOSD Malattie Rare del Globulo Rosso, Dipartimento di oncoematologia e pneumologia, AORN Cardarelli, Naples, Italy., Tartaglione I; Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania 'Luigi Vanvitelli', Napoli, Italy.
المصدر: British journal of haematology [Br J Haematol] 2024 May; Vol. 204 (5), pp. 2016-2024. Date of Electronic Publication: 2024 Mar 18.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Wiley-Blackwell
Original Publication: Oxford : Blackwell Scientific Publications
مواضيع طبية MeSH: beta-Thalassemia*/complications , beta-Thalassemia*/therapy, Humans ; Male ; Female ; Adult ; Case-Control Studies ; Middle Aged ; Italy/epidemiology ; Young Adult ; Chelation Therapy ; Hearing Loss/epidemiology ; Hearing Loss/etiology ; Adolescent ; Audiometry, Pure-Tone ; Hearing Loss, Sensorineural/epidemiology ; Hearing Loss, Sensorineural/etiology ; Prevalence
مستخلص: Background: Despite numerous studies, the true scenario of hearing loss in beta-thalassaemia remains rather nebulous.
Materials and Methods: Pure tone audiometry, chelation therapy, demographics and laboratory data of 376 patients (mean age 38.5 ± 16.6 years, 204 females, 66 non-transfusion-dependent) and 139 healthy controls (mean age 37.6 ± 17.7 years, 81 females) were collected.
Results: Patient and control groups did not differ for age (p = 0.59) or sex (p = 0.44). Hypoacusis rate was higher in patients (26.6% vs. 7.2%; p < 0.00001), correlated with male sex (32.6% in males vs. 21.8% in females; p = 0.01) and it was sensorineural in 79/100. Hypoacusis rate correlated with increasing age (p = 0.0006) but not with phenotype (13/66 non-transfusion-dependent vs. 87/310 transfusion-dependent patients; p = 0.16). Sensorineural-notch prevalence rate did not differ between patients (11.4%) and controls (12.2%); it correlated with age (p = 0.01) but not with patients' sex or phenotype. Among adult patients without chelation therapy, the sensorineural hypoacusis rate was non-significantly lower compared to chelation-treated patients while it was significantly higher compared to controls (p = 0.003).
Conclusions: Sensorineural hypoacusis rate is high in beta-thalassaemia (about 21%) and it increases with age and in males while disease severity or chelation treatment seems to be less relevant. The meaning of sensorineural-notch in beta-thalassaemia appears questionable.
(© 2024 British Society for Haematology and John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: beta‐thalassaemia; hearing loss; pure tone audiometry
تواريخ الأحداث: Date Created: 20240319 Date Completed: 20240514 Latest Revision: 20240514
رمز التحديث: 20240514
DOI: 10.1111/bjh.19401
PMID: 38500389
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2141
DOI:10.1111/bjh.19401