دورية أكاديمية
Hearing loss in beta-thalassaemia: An Italian multicentre case-control study.
العنوان: | Hearing loss in beta-thalassaemia: An Italian multicentre case-control study. |
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المؤلفون: | Manara R; Neuroradiology, Neurosciences Department, University of Padova, Padova, Italy.; DIMED, University of Padova, Padova, Italy., Brotto D; Section of Otorhinolaryngology, Neurosciences Department, University of Padova, Padova, Italy., Barillari MR; Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Costa G; Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Villani AV; Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania 'Luigi Vanvitelli', Napoli, Italy., Perna C; Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania 'Luigi Vanvitelli', Napoli, Italy., Ziello B; UOSD Malattie Rare del Globulo Rosso, Dipartimento di oncoematologia e pneumologia, AORN Cardarelli, Naples, Italy., di Salle F; Dipartimento di Medicina e Chirurgia, Scuola Medica Salernitana, Università di Salerno, Fisciano, Italy., Cantone E; Department of Neurosciences, Reproductive and Odontostomatologic Sciences, Unit of Ear, Nose and Throat, 'Federico II' University, Naples, Italy., Pasanisi A; Centro della Microcitemia 'A. Quarta' UOC di Ematologia con trapiannto Ospedale Perrino, Brindisi, Italy., De Michele E; Medicina Trasfusionale AUO 'San Giovanni di Dio e Ruggi D'Aragona', Salerno, Italy., Ciancio A; Unità Operativa Ematologia-Day Hospital di Talassemia, Ospedale 'Madonna delle Grazie', Matera, Italy., D'Urzo G; Dipartimento di Pediatria, Ospedale 'Umberto I', Nocera Inferiore, Italy., Valentino P; Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania 'Luigi Vanvitelli', Napoli, Italy., Perrotta S; Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania 'Luigi Vanvitelli', Napoli, Italy., Ricchi P; UOSD Malattie Rare del Globulo Rosso, Dipartimento di oncoematologia e pneumologia, AORN Cardarelli, Naples, Italy., Tartaglione I; Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania 'Luigi Vanvitelli', Napoli, Italy. |
المصدر: | British journal of haematology [Br J Haematol] 2024 May; Vol. 204 (5), pp. 2016-2024. Date of Electronic Publication: 2024 Mar 18. |
نوع المنشور: | Journal Article; Multicenter Study |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
مواضيع طبية MeSH: | beta-Thalassemia*/complications , beta-Thalassemia*/therapy, Humans ; Male ; Female ; Adult ; Case-Control Studies ; Middle Aged ; Italy/epidemiology ; Young Adult ; Chelation Therapy ; Hearing Loss/epidemiology ; Hearing Loss/etiology ; Adolescent ; Audiometry, Pure-Tone ; Hearing Loss, Sensorineural/epidemiology ; Hearing Loss, Sensorineural/etiology ; Prevalence |
مستخلص: | Background: Despite numerous studies, the true scenario of hearing loss in beta-thalassaemia remains rather nebulous. Materials and Methods: Pure tone audiometry, chelation therapy, demographics and laboratory data of 376 patients (mean age 38.5 ± 16.6 years, 204 females, 66 non-transfusion-dependent) and 139 healthy controls (mean age 37.6 ± 17.7 years, 81 females) were collected. Results: Patient and control groups did not differ for age (p = 0.59) or sex (p = 0.44). Hypoacusis rate was higher in patients (26.6% vs. 7.2%; p < 0.00001), correlated with male sex (32.6% in males vs. 21.8% in females; p = 0.01) and it was sensorineural in 79/100. Hypoacusis rate correlated with increasing age (p = 0.0006) but not with phenotype (13/66 non-transfusion-dependent vs. 87/310 transfusion-dependent patients; p = 0.16). Sensorineural-notch prevalence rate did not differ between patients (11.4%) and controls (12.2%); it correlated with age (p = 0.01) but not with patients' sex or phenotype. Among adult patients without chelation therapy, the sensorineural hypoacusis rate was non-significantly lower compared to chelation-treated patients while it was significantly higher compared to controls (p = 0.003). Conclusions: Sensorineural hypoacusis rate is high in beta-thalassaemia (about 21%) and it increases with age and in males while disease severity or chelation treatment seems to be less relevant. The meaning of sensorineural-notch in beta-thalassaemia appears questionable. (© 2024 British Society for Haematology and John Wiley & Sons Ltd.) |
References: | Tartaglione I, Carfora R, Brotto D, Barillari MR, Costa G, Perrotta S, et al. Hearing loss in Beta‐thalassemia: systematic review. J Clin Med. 2021;11(1):102. https://doi.org/10.3390/jcm11010102. Cohen A, Martin M, Mizanin J, Konkle DF, Schwartz E. Vision and hearing during deferoxamine therapy. J Pediatr. 1990;117(2):326–330. https://doi.org/10.1016/S0022‐3476(05)80556‐6. Önerci M, Aslan S, Gümrük F, Aksoy S, Belgin E, Özçelik T, et al. Audiologic and impedance metric findings within thalassaemic patients. Int J Pediatr Otorhinolaryngol. 1994;28(2–3):167–172. https://doi.org/10.1016/0165‐5876(94)90008‐6. Report of the informal working group on prevention of deafness and hearing impairment programme planning, Geneva, 18–21 June, Geneva, World Health Organization. 1991 [cited 2019 April 1]. Available from: http://www.who.int/iris/handle/10665/58839. Hoffman HJ, Ko CW, Themann CL, Dillon CF, Franks JR. Reducing noise‐induced hearing loss (NIHL) to achieve us healthy people 2010 goals. Am J Epidemiol. 2006;163(suppl_11):S122. https://doi.org/10.1093/aje/163.suppl_11.S122‐c. Faranoush M, Faranoush P, Heydari I, Foroughi‐Gilvaee MR, Azarkeivan A, Parsai Kia A, et al. Complications in patients with transfusion dependent thalassemia: a descriptive cross‐sectional study. Health Sci Rep. 2023;6(10):e1624. https://doi.org/10.1002/hsr2.1624. Aldè M, Ambrosetti U, Giuditta M, Cassinerio E. Piatti G. Effects on hearing after long‐term use of iron chelators in beta‐thalassemia: over twenty years of longitudinal follow‐up. Auris Nasus Larynx. 2023;51(2):271–275. https://doi.org/10.1016/j.anl.2023.10.005. Boulet SL, Boyle CA, Schieve LA. Health care use and health and functional impact of developmental disabilities among US children, 1997‐2005. Arch Pediatr Adolesc Med. 2009;163(1):19–26. https://doi.org/10.1001/archpediatrics.2008.506. Osma U, Kurtoglu E, Eyigor H, Yilmaz MD, Aygener N. Sensorineural hearing loss in β‐thalassemia patients treated with iron chelation. Ear Nose Throat J. 2015;94(12):481–485. Karimi M, Asadi‐Pooya AA, Khademi B, Asadi‐Pooya K, Yarmohammadi H. Evaluation of the incidence of sensorineural hearing loss in beta‐thalassemia major patients under regular chelation therapy with desferrioxamine. Acta Haematol. 2002;108(2):79–83. Sonbolestan M, Mokhtarinejad F, Omrani M. An evaluation of sensory neural hearing loss in thalassaemic patients treated with desferrioxamine and its risk factors. J Res Med Sci. 2005;10:210–216. Porter JB, Jaswon MS, Huehns ER, East CA, Hazell JWP. Desferrioxamine ototoxicity: evaluation of risk factors in thalassaemic patients and guidelines for safe dosage. Br J Haematol. 1989;73(3):403–409. https://doi.org/10.1111/j.1365‐2141.1989.tb07761.x. Manara R, Ponticorvo S, Perrotta S, Barillari MR, Costa G, Brotto D, et al. Auditory cortex hypoperfusion: a metabolic hallmark in beta thalassemia. Orphanet J Rare Dis. 2021;16(1):349. https://doi.org/10.1186/s13023‐021‐01969‐0. Walling AD, Dickson GM. Hearing loss in older adults. Am Fam Physician. 2012;85(12):1150–1156. Budak B, Bayar Muluk N, Gumruk F, Budak G. Pure tone and high frequency audiometries in beta thalassemia major. KBB Ve BBC Dergisi. 2008;16(1):10–15. Hansen RS, Scheel‐Hincke LL, Jeune B, Ahrenfeldt LJ. Sex differences in vision and hearing impairments across age and European regions: findings from SHARE Wien Klin Wochenschr. 2023;6:55–63. https://doi.org/10.1007/s00508‐023‐02223‐2. Marsh MN, Holbrook IB, Clark C, Shaffer JL. Tinnitus in a patient with beta‐thalassaemia intermedia on long‐term treatment with desferrioxamine. Postgrad Med J. 1981;57(671):582–584. https://doi.org/10.1136/pgmj.57.671.582. Orton RB, de Veber LL, Sulh HM. Ocular and auditory toxicity of long‐term, high‐dose subcutaneous deferoxamine therapy. Can J Ophthalmol. 1985;20(4):153–156. Sacco M, Meleleo D, Tricarico N, Greco Miani A, Serra E, Parlatore L. Evaluation of desferrioxamine ototoxicity in thalassemic patients. Follow‐up over a 5‐year period and results. Minerva Pediatr. 1994;46(5):225–230. Teli A, Economou M, Rudolf J, Tzovaras F, Gourtsa V, Kondou A, et al. Subclinical central nervous system involvement and thrombophilic status in young thalassemia intermedia patients of Greek origin. Blood Coagul Fibrinolysis. 2012;23(3):195–202. https://doi.org/10.1097/MBC.0b013e32834f0ac0. Vir D, Panda NK, Marwaha RK. Desferioximine induced ototoxicity in thalassemic patients. Ann Neurosci. 2010;17(4):182–184. https://doi.org/10.5214/ans.0972.7531.1017407. |
فهرسة مساهمة: | Keywords: beta‐thalassaemia; hearing loss; pure tone audiometry |
تواريخ الأحداث: | Date Created: 20240319 Date Completed: 20240514 Latest Revision: 20240514 |
رمز التحديث: | 20240514 |
DOI: | 10.1111/bjh.19401 |
PMID: | 38500389 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1365-2141 |
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DOI: | 10.1111/bjh.19401 |