دورية أكاديمية
Long-Term Glucocorticoid Exposure and Incident Cardiovascular Diseases-The Lifelines Cohort.
| العنوان: | Long-Term Glucocorticoid Exposure and Incident Cardiovascular Diseases-The Lifelines Cohort. |
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| المؤلفون: | van der Valk ES; Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., Mohseni M; Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., Iyer AM; Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., van den Hurk MJB; Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., Lengton R; Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., Kuckuck S; Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., Wester VL; Department of Internal Medicine, Division of Geriatric Medicine, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., Leenen PJM; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., Dik WA; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.; Laboratory of Medical Immunology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., Visser JA; Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., Kavousi M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., Mirzaian M; Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., van den Berg SAA; Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.; Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands., van Rossum EFC; Obesity Centre CGG, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands. |
| المصدر: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Sep 16; Vol. 109 (10), pp. 2520-2529. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| مواضيع طبية MeSH: | Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/etiology , Hair*/chemistry , Glucocorticoids*/adverse effects , Glucocorticoids*/analysis , Cortisone*/analysis , Cortisone*/metabolism , Hydrocortisone*/analysis , Hydrocortisone*/metabolism, Humans ; Male ; Middle Aged ; Female ; Adult ; Incidence ; Aged ; Cohort Studies ; Follow-Up Studies ; Longitudinal Studies ; Prospective Studies |
| مستخلص: | Context: Long-term glucocorticoid levels in scalp hair (HairGCs), including cortisol and the inactive form cortisone, represent the cumulative systemic exposure to glucocorticoids over months. HairGCs have repeatedly shown associations with cardiometabolic and immune parameters, but longitudinal data are lacking. Design: We investigated 6341 hair samples of participants from the Lifelines cohort study for cortisol and cortisone levels and associated these to incident cardiovascular diseases (CVD) during 5 to 7 years of follow-up. We computed the odds ratio (OR) of HairGC levels for incident CVD via logistic regression, adjusting for classical cardiovascular risk factors, and performed a sensitivity analysis in subcohorts of participants < 60 years and ≥ 60 years of age. We also associated HairGC levels to immune parameters (total leukocytes and subtypes). Results: Hair cortisone levels (available in n = 4701) were independently associated with incident CVD (P < .001), particularly in younger individuals (multivariate-adjusted OR 4.21, 95% CI 1.91-9.07 per point increase in 10-log cortisone concentration [pg/mg], P < .001). All immune parameters except eosinophils were associated with hair cortisone (all multivariate-adjusted P < .05). Conclusion: In this large, prospective cohort study, we found that long-term cortisone levels, measured in scalp hair, represent a relevant and significant predictor for future CVD in younger individuals. These results highlight glucocorticoid action as possible treatment target for CVD prevention, where hair glucocorticoid measurements could help identify individuals that may benefit from such treatments. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.) |
| References: | Obesity (Silver Spring). 2017 Mar;25(3):539-544. (PMID: 28229550) Sci Rep. 2020 Dec 31;10(1):22456. (PMID: 33384452) J Clin Endocrinol Metab. 2008 May;93(5):1526-40. (PMID: 18334580) Nat Rev Immunol. 2022 Apr;22(4):251-265. (PMID: 34389841) Curr Cardiol Rep. 2019 Aug 30;21(10):116. (PMID: 31471749) Eur J Endocrinol. 2019 Oct;181(4):429-438. (PMID: 31325907) Ann Epidemiol. 2010 Jul;20(7):547-54. (PMID: 20538198) Int J Epidemiol. 2022 Oct 13;51(5):e295-e302. (PMID: 34897450) Sri Lankan J Appl Stat. 2014;5(4):227-246. (PMID: 27110215) Bioinformatics. 2019 Mar 15;35(6):1076-1078. (PMID: 30165396) Pituitary. 2022 Oct;25(5):750-753. (PMID: 35869339) J Clin Endocrinol Metab. 2013 May;98(5):2078-83. (PMID: 23596141) Curr Obes Rep. 2018 Jun;7(2):193-203. (PMID: 29663153) Clin Endocrinol (Oxf). 2015 Aug;83(2):162-6. (PMID: 25823708) Prev Med. 2020 Mar;132:105986. (PMID: 31958478) Diabetes Obes Metab. 2023 Mar;25(3):832-843. (PMID: 36478142) Neuroimmunomodulation. 1994 Jan;1(1):2-13. (PMID: 8528880) Obes Rev. 2022 Mar;23(3):e13376. (PMID: 34811866) Minerva Endocrinol. 2017 Jun;42(2):151-163. (PMID: 27973460) Psychoneuroendocrinology. 2021 Sep 25;134:105422. (PMID: 34666286) Int J Mol Sci. 2021 Aug 24;22(17):. (PMID: 34502027) Ann N Y Acad Sci. 2000;917:4-18. (PMID: 11268367) Obes Rev. 2022 Mar;23(3):e13401. (PMID: 34837448) Psychoneuroendocrinology. 2016 Sep;71:12-8. (PMID: 27235635) Clin Chem Lab Med. 2023 Jul 25;62(1):118-127. (PMID: 37485925) J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):257-265. (PMID: 30412218) J Clin Endocrinol Metab. 2013 Jun;98(6):2573-80. (PMID: 23585660) Psychoneuroendocrinology. 2015 Dec;62:301-18. (PMID: 26356039) J Endocrinol Invest. 1996 Mar;19(3):175-82. (PMID: 8743284) Int J Epidemiol. 2015 Aug;44(4):1172-80. (PMID: 25502107) Diabetes Obes Metab. 2022 May;24(5):881-890. (PMID: 35014156) Front Endocrinol (Lausanne). 2019 Feb 07;10:54. (PMID: 30792695) J Am Heart Assoc. 2018 Jan 6;7(1):. (PMID: 29306895) Diabetes Care. 2010 Jul;33(7):1516-22. (PMID: 20413513) Stress. 2011 Jan;14(1):73-81. (PMID: 20812871) Rheum Dis Clin North Am. 2016 Feb;42(1):15-31, vii. (PMID: 26611548) J Clin Endocrinol Metab. 2024 Sep 16;109(10):2520-2529. (PMID: 38500477) Psychoneuroendocrinology. 2017 Mar;77:261-274. (PMID: 28135674) |
| معلومات مُعتمدة: | Elisabeth Foundation; 91716453 Netherlands Organization of Scientific Research NWO |
| فهرسة مساهمة: | Keywords: cardiovascular diseases; hair glucocorticoids |
| المشرفين على المادة: | 0 (Glucocorticoids) V27W9254FZ (Cortisone) WI4X0X7BPJ (Hydrocortisone) |
| تواريخ الأحداث: | Date Created: 20240319 Date Completed: 20240916 Latest Revision: 20240918 |
| رمز التحديث: | 20240918 |
| مُعرف محوري في PubMed: | PMC11403319 |
| DOI: | 10.1210/clinem/dgae081 |
| PMID: | 38500477 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-7197 |
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| DOI: | 10.1210/clinem/dgae081 |