دورية أكاديمية
Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method.
| العنوان: | Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method. |
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| المؤلفون: | Mattusch AM; Department of Biochemical and Chemical Engineering, TU Dortmund University, Germany., Schaldach G; Department of Biochemical and Chemical Engineering, TU Dortmund University, Germany., Bartsch J; Department of Biochemical and Chemical Engineering, TU Dortmund University, Germany., Thommes M; Department of Biochemical and Chemical Engineering, TU Dortmund University, Germany. |
| المصدر: | Pharmaceutical development and technology [Pharm Dev Technol] 2024 Apr; Vol. 29 (4), pp. 281-290. Date of Electronic Publication: 2024 Mar 19. |
| نوع المنشور: | Journal Article; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9610932 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-9867 (Electronic) Linking ISSN: 10837450 NLM ISO Abbreviation: Pharm Dev Technol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Monticello, NY : Marcel Dekker, c1996- |
| مواضيع طبية MeSH: | Solubility* , Hydrodynamics*, Tablets/chemistry ; Drug Liberation ; Pharmacopoeias as Topic ; Computer Simulation ; Chemistry, Pharmaceutical/methods ; Temperature |
| مستخلص: | For a solid understanding of drug characteristics, in vitro measurement of the intrinsic dissolution rate is important. Hydrodynamics are often emphasized as the decisive parameter influencing the dissolution. In this study, experiments and computational fluid dynamic (CFD) simulations showed that the mixing behavior in the rotating disc apparatus causes an inhomogeneous flow field and a systematic error in the calculation of the intrinsic dissolution rate. This error is affected by both the experimental time and the velocity. Due to the rotational movement around the tablet center, commonly utilized in pharmacopeia methods, a broad variance is present with regard to the impact of fluid velocity on individual particles of the specimen surface. As this is significantly reduced in the case of uniform overflow, the flow channel is recommended for investigating the dissolution behavior. It is shown that rotating disc measurements can be compared with flow channel measurements after adjusting the measured data for the rotating disc based on a proposed, representative Reynolds number and a suggested apparatus-dependent correction factor. Additionally, modeling the apparatus-independent intrinsic dissolution rate for different temperatures in the rotating disc apparatus is possible using the adapted Levich's equation. |
| فهرسة مساهمة: | Keywords: CFD; IDR; Rotating disc; apparatus-independent; flow channel; hydrodynamics; intrinsic dissolution; levich; pharmacopeia; reynolds number |
| المشرفين على المادة: | 0 (Tablets) |
| تواريخ الأحداث: | Date Created: 20240319 Date Completed: 20240430 Latest Revision: 20240430 |
| رمز التحديث: | 20240501 |
| DOI: | 10.1080/10837450.2024.2329115 |
| PMID: | 38501605 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1097-9867 |
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| DOI: | 10.1080/10837450.2024.2329115 |