دورية أكاديمية
أعرض في EDS

Efficacy of photodynamic therapy as an adjunct to scaling and root planing on clinical parameters and microbial composition in subgingival plaque of periodontitis patients: A split-mouth randomized clinical trial.

التفاصيل البيبلوغرافية
العنوان: Efficacy of photodynamic therapy as an adjunct to scaling and root planing on clinical parameters and microbial composition in subgingival plaque of periodontitis patients: A split-mouth randomized clinical trial.
المؤلفون: Nie M; Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Periodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, China., Huang P; Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China., Peng P; State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China., Shen D; Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China., Zhao L; Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China., Jiang D; Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China., Shen Y; Department of Periodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, China., Wei L; Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Bible PW; College of Arts and Sciences of Marian University, Indianapolis, Indiana, USA., Yang J; Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China., Wang J; Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China., Wu Y; Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
المصدر: Journal of periodontology [J Periodontol] 2024 Jun; Vol. 95 (6), pp. 535-549. Date of Electronic Publication: 2024 Mar 19.
نوع المنشور: Journal Article; Randomized Controlled Trial; Comparative Study
اللغة: English
بيانات الدورية: Publisher: American Academy of Periodontology Country of Publication: United States NLM ID: 8000345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-3670 (Electronic) Linking ISSN: 00223492 NLM ISO Abbreviation: J Periodontol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Chicago] American Academy of Periodontology.
مواضيع طبية MeSH: Photochemotherapy*/methods , Dental Scaling*/methods , Root Planing*/methods , Dental Plaque*/microbiology , Periodontal Pocket*/microbiology , Periodontal Pocket*/therapy , Periodontal Pocket*/drug therapy, Humans ; Male ; Female ; Middle Aged ; Adult ; Treatment Outcome ; Follow-Up Studies ; Combined Modality Therapy ; Periodontitis/microbiology ; Periodontitis/therapy ; Periodontitis/drug therapy ; Periodontal Attachment Loss/therapy ; Periodontal Attachment Loss/microbiology ; Periodontal Attachment Loss/drug therapy ; Periodontal Index ; Photosensitizing Agents/therapeutic use ; RNA, Ribosomal, 16S/analysis ; Bacteria, Anaerobic/drug effects
مستخلص: Background: The aim of this study was to assess the efficacy of photodynamic therapy (PDT) as an adjunct to scaling and root planing (SRP) on clinical parameters and microbial composition in subgingival plaque of periodontitis patients.
Methods: Seventeen patients were included in this split-mouth randomized clinical trial. Sites with probing pocket depth (PPD) ≥5 mm in combination with bleeding on probing in different quadrants were randomized into the control group, the group with a single PDT application right after SRP, and the group with three repeated PDT applications 1 week after SRP. The subgingival plaque was collected for 16S rRNA gene sequencing at baseline, Week 2, and Week 8.
Results: Seventeen patients with 60 sites completed this 8-week follow-up, and 157 subgingival plaques were successfully analyzed by sequencing. Significant improvements were observed in two primary outcomes: PPD at Week 8 and subgingival microbial composition. Compared to the control group, the repeated-PDT group showed a notable improvement in PPD, substantial alterations in the microbial profile, including a reduction in α-diversity and anaerobic bacteria, and an increase in aerobic bacteria at Week 2. Secondary outcomes, such as clinical attachment level and sulcus bleeding index, also showed improvement at Week 8. Furthermore, both the single- and repeated-PDT groups exhibited a decrease in periodontopathogens and an increase in beneficial bacteria compared with baseline.
Conclusion: PDT promotes changes in the microbial composition of periodontitis patients' subgingival plaque in a direction favorable to periodontal health, and repeated PDT is a promising adjunctive therapy for periodontal treatment.
(© 2024 American Academy of Periodontology.)
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معلومات مُعتمدة: 82071127 National Natural Science Foundation of China; 82270990 National Natural Science Foundation of China; 82170970 National Natural Science Foundation of China; 20221A011101 Guangzhou Health Science and Technology General Guidance Project; 202201020540 Basic Research Project Jointly Funded by Guangzhou Municipal Science and Technology Bureau and Guangzhou Medical University
فهرسة مساهمة: Keywords: 16S rRNA gene sequencing; periodontitis; photodynamic therapy; subgingival plaque
المشرفين على المادة: 0 (Photosensitizing Agents)
0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20240319 Date Completed: 20240626 Latest Revision: 20240626
رمز التحديث: 20240627
DOI: 10.1002/JPER.23-0195
PMID: 38501762
قاعدة البيانات: MEDLINE
الوصف
تدمد:1943-3670
DOI:10.1002/JPER.23-0195