دورية أكاديمية
Clinical and laboratory characteristics of patients hospitalized with severe COVID-19 in New Orleans, August 2020 to September 2021.
العنوان: | Clinical and laboratory characteristics of patients hospitalized with severe COVID-19 in New Orleans, August 2020 to September 2021. |
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المؤلفون: | Drouin A; Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70130, USA.; University Medical Center, New Orleans, LA, USA., Plumb ID; Applied Epidemiology Studies Team, Epidemiology Branch, and on detail to the Global Respiratory Viruses Branch Coronavirus and Other Respiratory Viruses Division, Centers for Disease Control, Atlanta, GA, USA., McCullough M; Eagle Health Analytics, Atlanta, GA, USA., James Gist J; Eagle Health Analytics, Atlanta, GA, USA., Liu S; Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70130, USA., Theberge M; Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70130, USA., Katz J; Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70130, USA., Moreida M; Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70130, USA., Flaherty S; School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA., Chatwani B; School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA., Briggs Hagen M; Applied Epidemiology Studies Team, Epidemiology Branch, and on detail to the Global Respiratory Viruses Branch Coronavirus and Other Respiratory Viruses Division, Centers for Disease Control, Atlanta, GA, USA., Midgley CM; Applied Epidemiology Studies Team, Epidemiology Branch, and on detail to the Global Respiratory Viruses Branch Coronavirus and Other Respiratory Viruses Division, Centers for Disease Control, Atlanta, GA, USA., Fusco D; Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70130, USA. dfusco@tulane.edu.; University Medical Center, New Orleans, LA, USA. dfusco@tulane.edu.; School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA. dfusco@tulane.edu. |
المصدر: | Scientific reports [Sci Rep] 2024 Mar 19; Vol. 14 (1), pp. 6539. Date of Electronic Publication: 2024 Mar 19. |
نوع المنشور: | Review; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | COVID-19*/diagnosis , COVID-19*/epidemiology, Humans ; Middle Aged ; Aged ; SARS-CoV-2 ; Cohort Studies ; New Orleans ; Hospitalization |
مستخلص: | Louisiana experienced high morbidity and mortality from COVID-19. To assess possible explanatory factors, we conducted a cohort study (ClinSeqSer) of patients hospitalized with COVID-19 in New Orleans during August 2020-September 2021. Following enrollment, we reviewed medical charts, and performed SARS-CoV-2 RT-PCR testing on nasal and saliva specimens. We used multivariable logistic regression to assess associations between patient characteristics and severe illness, defined as ≥ 6 L/min oxygen or intubation. Among 456 patients, median age was 56 years, 277 (60.5%) were Black non-Hispanic, 436 (95.2%) had underlying health conditions, and 358 were unvaccinated (92.0% of 389 verified). Overall, 187 patients (40.1%) had severe illness; 60 (13.1%) died during admission. In multivariable models, severe illness was associated with age ≥ 65 years (OR 2.08, 95% CI 1.22-3.56), hospitalization > 5 days after illness onset (OR 1.49, 95% CI 1.01-2.21), and SARS CoV-2 cycle threshold (Ct) result of < 32 in saliva (OR 4.79, 95% CI 1.22-18.77). Among patients who were predominantly Black non-Hispanic, unvaccinated and with underlying health conditions, approximately 1 in 3 patients had severe COVID-19. Older age and delayed time to admission might have contributed to high case-severity. An association between case-severity and low Ct value in saliva warrants further investigation. (© 2024. The Author(s).) |
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معلومات مُعتمدة: | U01CK000480 United States CC CDC HHS |
فهرسة مساهمة: | Keywords: Anti-N antibody; COVID-19; SARS CoV-2; qRT-PCR |
تواريخ الأحداث: | Date Created: 20240320 Date Completed: 20240321 Latest Revision: 20240323 |
رمز التحديث: | 20240323 |
مُعرف محوري في PubMed: | PMC10951213 |
DOI: | 10.1038/s41598-024-57306-5 |
PMID: | 38503862 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-024-57306-5 |