دورية أكاديمية
Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart.
| العنوان: | Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart. |
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| المؤلفون: | Grune J; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité, Berlin, Germany (J.G.).; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Institute of Physiology, Germany (J.G.).; German Center for Cardiovascular Research, Partner Site Berlin (J.G.)., Bajpai G; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston., Ocak PT; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Cardiology, University Hospital Heidelberg, Germany (P.T.O.)., Kaufmann E; Meakins-Christie Laboratories, Department of Medicine, Department of Microbiology and Immunology, Department of Pathology, Research Institute McGill University Health Centre, and McGill International TB Centre Montreal, Canada (E.K., K.A.T., M.D.).; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada (E.K.)., Mentkowski K; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston., Pabel S; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Internal Medicine II, University Medical Center Regensburg, Germany (S.P.)., Kumowski N; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Internal Medicine I, University Hospital Aachen, Rheinisch-Westfälische Technische Hochschule Aachen University, Germany (N.K.)., Pulous FE; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston., Tran KA; Meakins-Christie Laboratories, Department of Medicine, Department of Microbiology and Immunology, Department of Pathology, Research Institute McGill University Health Centre, and McGill International TB Centre Montreal, Canada (E.K., K.A.T., M.D.)., Rohde D; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston., Zhang S; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston., Iwamoto Y; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston., Wojtkiewicz GR; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston., Vinegoni C; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston., Green U; Department of Pathology, Center for Integrated Diagnostics (U.G., J.K.L.), Massachusetts General Hospital and Harvard Medical School, Boston., Swirski FK; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY (F.K.S.)., Stone JR; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA (J.R.S.).; Massachusetts General Hospital, Boston (J.R.S.)., Lennerz JK; Department of Pathology, Center for Integrated Diagnostics (U.G., J.K.L.), Massachusetts General Hospital and Harvard Medical School, Boston., Divangahi M; Meakins-Christie Laboratories, Department of Medicine, Department of Microbiology and Immunology, Department of Pathology, Research Institute McGill University Health Centre, and McGill International TB Centre Montreal, Canada (E.K., K.A.T., M.D.)., Hulsmans M; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston., Nahrendorf M; Center for Systems Biology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Radiology (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., C.V., M.H., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.; Gordon Center for Medical Imaging (M.N.).; Department of Internal Medicine, University Hospital Wuerzburg, Germany (M.N.). |
| المصدر: | Circulation [Circulation] 2024 Jul 02; Vol. 150 (1), pp. 49-61. Date of Electronic Publication: 2024 Mar 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [Dallas, Tex., etc., American Heart Association, etc.] |
| مواضيع طبية MeSH: | COVID-19*/immunology , COVID-19*/complications , COVID-19*/pathology , Respiratory Distress Syndrome*/immunology , Respiratory Distress Syndrome*/etiology , Respiratory Distress Syndrome*/pathology , Respiratory Distress Syndrome*/virology , SARS-CoV-2* , Cardiomyopathies*/immunology , Cardiomyopathies*/etiology , Cardiomyopathies*/pathology , Cardiomyopathies*/virology, Animals ; Humans ; Mice ; Male ; Female ; Macrophages/immunology ; Macrophages/pathology ; Macrophages/metabolism ; Inflammation/pathology ; Middle Aged ; Myocardium/pathology ; Myocardium/immunology ; Mice, Inbred C57BL ; Aged |
| مستخلص: | Background: Viral infections can cause acute respiratory distress syndrome (ARDS), systemic inflammation, and secondary cardiovascular complications. Lung macrophage subsets change during ARDS, but the role of heart macrophages in cardiac injury during viral ARDS remains unknown. Here we investigate how immune signals typical for viral ARDS affect cardiac macrophage subsets, cardiovascular health, and systemic inflammation. Methods: We assessed cardiac macrophage subsets using immunofluorescence histology of autopsy specimens from 21 patients with COVID-19 with SARS-CoV-2-associated ARDS and 33 patients who died from other causes. In mice, we compared cardiac immune cell dynamics after SARS-CoV-2 infection with ARDS induced by intratracheal instillation of Toll-like receptor ligands and an ACE2 (angiotensin-converting enzyme 2) inhibitor. Results: In humans, SARS-CoV-2 increased total cardiac macrophage counts and led to a higher proportion of CCR2 + (C-C chemokine receptor type 2 positive) macrophages. In mice, SARS-CoV-2 and virus-free lung injury triggered profound remodeling of cardiac resident macrophages, recapitulating the clinical expansion of CCR2 + macrophages. Treating mice exposed to virus-like ARDS with a tumor necrosis factor α-neutralizing antibody reduced cardiac monocytes and inflammatory MHCII lo CCR2 + macrophages while also preserving cardiac function. Virus-like ARDS elevated mortality in mice with pre-existing heart failure. Conclusions: Our data suggest that viral ARDS promotes cardiac inflammation by expanding the CCR2 + macrophage subset, and the associated cardiac phenotypes in mice can be elicited by activating the host immune system even without viral presence in the heart. Competing Interests: Disclosures M.N. has received funds or material research support from Alnylam, Biotronik, CSL Behring, GlycoMimetics, GSK, Medtronic, Novartis, and Pfizer, as well as consulting fees from Lilly, Biogen, Gimv, IFM Therapeutics, Molecular Imaging, Sigilon, and Verseau Therapeutics. The other authors report no conflicts. |
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| معلومات مُعتمدة: | P01 HL142494 United States HL NHLBI NIH HHS; R01 HL149647 United States HL NHLBI NIH HHS; R01 HL155097 United States HL NHLBI NIH HHS; R35 HL139598 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: CCR2; SARS-CoV-2; acute respiratory distress syndrome; macrophage |
| تواريخ الأحداث: | Date Created: 20240320 Date Completed: 20240701 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| مُعرف محوري في PubMed: | PMC11216864 |
| DOI: | 10.1161/CIRCULATIONAHA.123.066433 |
| PMID: | 38506045 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1524-4539 |
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| DOI: | 10.1161/CIRCULATIONAHA.123.066433 |